P39 The dentato-rubro-thalamic tract (DRT) is the true target structure in deep brain stimulation (DBS) for therapy refractory tremor: Evidence from a diffusion tensor imaging (DTI) tractography study

Basal Ganglia ◽  
2011 ◽  
Vol 1 (2) ◽  
pp. 119-120
Author(s):  
V.A. Coenen ◽  
N. Allert ◽  
M.S. Paus ◽  
H. Urbach ◽  
B. Mädler
Keyword(s):  
Diffusion Tensor Imaging ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Diffusion Tensor ◽  
Target Structure ◽  
True Target ◽  
Dti Tractography ◽  
Diffusion Tensor Imaging Dti ◽  
Deep Brain

Post-Traumatic Tremor and Thalamic Deep Brain Stimulation: Evidence for Use of Diffusion Tensor Imaging

2016 ◽  
Vol 96 ◽  
pp. 607.e7-607.e11 ◽  
Author(s):  
Sandra G.J. Boccard ◽  
Pedro Rebelo ◽  
Binith Cheeran ◽  
Alexander Green ◽  
James J. FitzGerald ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Diffusion Tensor ◽  
Post Traumatic ◽  
Deep Brain

scholarly journals Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease

2014 ◽  
Vol 121 (4) ◽  
pp. 929-935 ◽  
Author(s):  
Nicholas Said ◽  
W. Jeff Elias ◽  
Prashant Raghavan ◽  
Alan Cupino ◽  
Nicholas Tustison ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Brain Stimulation ◽  
Diffusion Tensor ◽  
Distance Measurements ◽  
Postoperative Mri ◽  
Mri Studies ◽  
Lead Placement ◽  
Dti Tractography ◽  
Deep Brain

Object The purpose of this study was to investigate whether diffusion tensor imaging (DTI) of the corticospinal tract (CST) is a reliable surrogate for intraoperative macrostimulation through the deep brain stimulation (DBS) leads. The authors hypothesized that the distance on MRI from the DBS lead to the CST as determined by DTI would correlate with intraoperative motor thresholds from macrostimulations through the same DBS lead. Methods The authors retrospectively reviewed pre- and postoperative MRI studies and intraoperative macrostimulation recordings in 17 patients with Parkinson disease (PD) treated by DBS stimulation. Preoperative DTI tractography of the CST was coregistered with postoperative MRI studies showing the position of the DBS leads. The shortest distance and the angle from each contact of each DBS lead to the CST was automatically calculated using software-based analysis. The distance measurements calculated for each contact were evaluated with respect to the intraoperative voltage thresholds that elicited a motor response at each contact. Results There was a nonsignificant trend for voltage thresholds to increase when the distances between the DBS leads and the CST increased. There was a significant correlation between the angle and the voltage, but the correlation was weak (coefficient of correlation [R] = 0.36). Conclusions Caution needs to be exercised when using DTI tractography information to guide DBS lead placement in patients with PD. Further studies are needed to compare DTI tractography measurements with other approaches such as microelectrode recordings and conventional intraoperative MRI–guided placement of DBS leads.

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