Enhancement of Adaptive Resistance against a Variety of Chronic Stress Conditions by Plant Adaptogens; Protective Effects on Survival and Embryonic Development of Lymnaea stagnalis

2012 ◽  
Keyword(s):  
Embryonic Development ◽  
Chronic Stress ◽  
Lymnaea Stagnalis ◽  
Stress Conditions ◽  
Protective Effects ◽  
Adaptive Resistance ◽  
Plant Adaptogens

Protective Effects of Andrographis paniculata Extract and Pure Andrographolide Against Chronic Stress-Triggered Pathologies in Rats

2014 ◽  
Vol 34 (8) ◽  
pp. 1111-1121 ◽  
Author(s):  
Ajit Kumar Thakur ◽  
Upendra Kumar Soni ◽  
Geeta Rai ◽  
Shyam Sunder Chatterjee ◽  
Vikas Kumar
Keyword(s):  
Chronic Stress ◽  
Andrographis Paniculata ◽  
Protective Effects

scholarly journals Sex-dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats

Hippocampus ◽  
2013 ◽  
Vol 23 (6) ◽  
pp. 476-487 ◽  
Author(s):  
Katharina M. Hillerer ◽  
Inga D. Neumann ◽  
Sebastien Couillard-Despres ◽  
Ludwig Aigner ◽  
David A. Slattery
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Stress Conditions

Protective effects of myricetin on chronic stress-induced cognitive deficits

Neuroreport ◽  
2016 ◽  
Vol 27 (9) ◽  
pp. 652-658 ◽  
Author(s):  
Qi-Min Wang ◽  
Gui-Lin Wang ◽  
Ze-Gang Ma
Keyword(s):  
Chronic Stress ◽  
Cognitive Deficits ◽  
Protective Effects

scholarly journals Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions

2019 ◽  
Vol 30 (1) ◽  
pp. 111-128.e6 ◽  
Author(s):  
Chi Kin Ip ◽  
Lei Zhang ◽  
Aitak Farzi ◽  
Yue Qi ◽  
Ireni Clarke ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Stress Conditions

scholarly journals Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory

2013 ◽  
Vol 16 (5) ◽  
pp. 1105-1113 ◽  
Author(s):  
Karem H. Alzoubi ◽  
Marisa Srivareerat ◽  
Trinh T. Tran ◽  
Karim A. Alkadhi
Keyword(s):  
Chronic Stress ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Short Term Memory ◽  
Neuroprotective Effect ◽  
Stress Conditions ◽  
Nicotine Treatment ◽  
Memory Tests ◽  
Α7 Nachrs

Abstract We have previously shown that nicotine prevents stress-induced memory impairment. In this study, we have investigated the role of α7- and α4β2-nicotinic acetylcholine receptors (nAChRs) in the protective effect of nicotine during chronic stress conditions. Chronic psychosocial stress was induced using a form of rat intruder model. During stress, specific antagonist for either α7-nAChRs [methyllycaconitine (MLA)] or α4β2-nAChRs [dihydro-β-erythroidine (DHβE)] was infused into the hippocampus using a 4-wk osmotic pump at a rate of 82 µg/side.d and 41 µg/side.d, respectively. Three weeks after the start of infusion, all rats were subjected to a series of cognitive tests in the radial arm water maze (RAWM) for six consecutive days or until the animal reached days to criterion (DTC) in the fourth acquisition trial and in all memory tests. DTC is defined as the number of days the animal takes to make no more than one error in three consecutive days. In the short-term memory test, MLA-infused stressed/nicotine-treated rats made similar errors to those of stress and significantly more errors compared to those of stress/nicotine, nicotine or control groups. This finding was supported by the DTC values for the short memory tests. Thus, MLA treatment blocked the neuroprotective effect of nicotine during chronic stress. In contrast, DHβE infusion did not affect the RAWM performance of stress/nicotine animals. These results strongly suggest the involvement of α7-nAChRs, but not α4β2-nAChRs, in the neuroprotective effect of chronic nicotine treatment during chronic stress conditions.

scholarly journals Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Anastasiya Kasian ◽  
Timur Kolomin ◽  
Lyudmila Andreeva ◽  
Elena Bondarenko ◽  
Nikolay Myasoedov ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Anxiolytic Effect ◽  
Chronic Mild Stress ◽  
Stress Conditions ◽  
Mild Stress ◽  
Unpredictable Chronic Mild Stress ◽  
Elevated Plus Maze Test ◽  
Plus Maze ◽  
The Individual ◽  
Benzodiazepine Drugs

It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.

scholarly journals SPECIFIC FEATURES OF EMBRYONIC DEVELOPMENT OF POND SNAIL (LYMNAEA STAGNALIS L.) UNDER ANTHROPOGENIC INFLUENCE OF CHLORIDE COMPOUNDS IN WATER

2021 ◽  
Vol 2021 (3) ◽  
pp. 134-141
Author(s):  
Aleksandr Gorbunov ◽  
Dmitry Nikiforov-Nikishin ◽  
Oleg Gorbunov
Keyword(s):  
Embryonic Development ◽  
Lymnaea Stagnalis ◽  
Water Environment ◽  
Model Organism ◽  
High Sensitivity ◽  
Biological Indicators ◽  
Anthropogenic Factors ◽  
Pond Snail ◽  
Integral Parameter ◽  
Egg Shells

The article highlights the research of embryonic development of hydrobionts under the influence of anthropogenic factors of water solutions – chlorobenzene and tetrachloroethylene. To detect the toxicity of chloride pollutants in a freshwater reservoir, representatives of benthic mollusks (big pond snail Lymnaea stagnalis L.) were used as a model organism. According to the results of research, it was found that at a concentration of 0.01 mg/l of chlorobenzene solution individual anomalies of embryonic development of the pond fish are observed, but at higher concentrations its development is delayed by 5-6 stages in comparison with the control. As an integral parameter of pond fish development, we can take indicators of the biological toxicity criterion: Hatchling and its survival over a 10-day period after leaving the egg shells. Changes in the physiological parameters of pond fish embryos begin with a chlorobenzene concentration of 0.01 mg/l; the maximum permissible concentration for tetrachloroethylene for the considered biological indicators should be considered 0.05 mg/l. It is noted that in big pond snail (Lymnaea stagnalis L.) the hatch of juveniles from egg shells is the most sensitive indicator when determining the toxicity of an aqueous solution; and less sensitive indicators are the number of eggs laid and the survival of juveniles in the first 10 days after hatching. The test object used is a large pond, which has shown a high sensitivity to contamination of the water environment with chlorinated ecotoxicants and can be recommended for a comprehensive quality assessment when biotesting freshwater waters

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