A clinical protocol for analysis of the structural integrity of the Medtronic CoreValve System® frame and its application in patients with 1-year minimum follow-up

2010 ◽  
Vol 5 (6) ◽  
pp. 680-686 ◽  
Author(s):  
Nicolo Piazza ◽  
Eberhard Grube ◽  
Ulrich Gerckens ◽  
Gerhard Schuler ◽  
Axel Linke ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Clinical Protocol ◽  
Medtronic Corevalve

Clinical Assessment of Oropharyngeal Motor Development in Young Children

1987 ◽  
Vol 52 (3) ◽  
pp. 271-277 ◽  
Author(s):  
JoAnne Robbins ◽  
Thomas Klee
Keyword(s):  
Clinical Application ◽  
Clinical Assessment ◽  
Motor Development ◽  
Structural Integrity ◽  
Vocal Tract ◽  
Developmental Change ◽  
Clinical Protocol ◽  
Motor Functioning ◽  
Motor Abilities ◽  
Speech Motor

A clinical protocol was developed for the purpose of assessing the oral and speech motor abilities of children. An 86-item test was administered to 90 normally developing children aged 2:6–6:11. Evaluations of the structural integrity of the vocal tract did not show developmental change, although evaluations of oral and speech motor functioning changed significantly with age. The functional portion of the protocol was most sensitive to developmental change up to age 3:6, with an asymptote in performance thereafter. Clinical application of the protocol is discussed.

Prevention of recurrent herpes labialis outbreaks through low-intensity laser therapy: a clinical protocol with 3-year follow-up

2011 ◽  
Vol 27 (5) ◽  
pp. 1077-1083 ◽  
Author(s):  
Carlos de Paula Eduardo ◽  
Letícia Mello Bezinelli ◽  
Fernanda de Paula Eduardo ◽  
Roberta Marques da Graça Lopes ◽  
Karen Müller Ramalho ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Herpes Labialis ◽  
Clinical Protocol ◽  
Low Intensity ◽  
Recurrent Herpes ◽  
Low Intensity Laser Therapy ◽  
Intensity Laser

Comparison of R5 and ASME NH Creep-Fatigue Damage Assessment Methodologies

2013 ◽  
Author(s):  
Michael Sheridan ◽  
David Knowles ◽  
Oliver Montgomery
Keyword(s):  
Fatigue Damage ◽  
Structural Integrity ◽  
Temperature Response ◽  
Creep Damage ◽  
Basic Principles ◽  
Metallic Structures ◽  
Reference Stress ◽  
Creep Fatigue ◽  
Design Generation

The R5 volume 2/3 procedures [1] were developed by British Energy (now EDF Energy) to assess the high temperature response of uncracked metallic structures under steady state or cyclic loading. They contain the basic principles of: • Application of reference stress methods • Consideration of elastic follow up • A ductility exhaustion approach to calculate creep damage accumulation. These considerations represent a fundamental distinction from ASME BPVC Section III, Subsection NH [2]. This paper draws on literature review and experience to explain the principal differences in the limits of application, cycle construction and damage calculation between these codes/procedures focusing on creep-fatigue damage determination. The implications of the differences between the codes and standards are explored. The output of this work is aimed at two groups of structural integrity engineers; those using these codes and standards to assess existing conventional and nuclear plant, and also those looking to ASME and R5 to design Generation IV PWRs with design temperatures much elevated from those of Generation III and III+. The conclusions from this paper offer some practical guidance to structural integrity engineers which may assist in selecting the more appropriate procedure to assess creep-fatigue damage for a particular situation.

scholarly journals Limbal Stem Cell-Sparing Corneoscleroplasty with Peripheral Intralamellar Tuck: A New Surgical Technique for Keratoglobus

2017 ◽  
Vol 8 (1) ◽  
pp. 279-287
Author(s):  
Elias Jarade ◽  
Rafic Antonios ◽  
Sylvain el-Khoury
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Structural Integrity ◽  
Single Step ◽  
Limbal Stem Cells ◽  
Host Cornea ◽  
Limbal Stem Cell ◽  
The Right ◽  
New Surgical Technique

Purpose: To describe the technique of limbal stem cell-sparing corneoscleroplasty for the management of advanced keratoglobus. Methods: A patient with bilateral advanced keratoglobus, with best-corrected visual acuity of 20/400 in the right eye and 20/200 in the left eye, underwent limbal stem cell-sparing corneoscleroplasty of the right eye. Initially, a 360-degree limbal incision with 200-μm depth was created, followed by a sublimbal tunnel dissection into the sclera, in order to conserve stem cells. Next, a limbus-to-limbus lamellar keratectomy at 200-μm depth was performed. Meanwhile, a donor corneoscleral button with preserved endothelium of the central 8 mm was fashioned. Prior to suturing the donor corneoscleral graft using a modified suturing technique to cover its scleral component, a full-thickness trephination of 8-mm diameter was completed in the central host cornea. Results: Reepithelialization occurred within the first week. No episodes of rejection, intraocular pressure spikes, or epithelial breakdown were observed postoperatively. At the 6-month follow-up, the patient had 20/70 best-corrected vision and a smooth cornea with regular astigmatism on topography. Conclusion: Limbal stem cell-sparing corneoscleroplasty is a single-step technique for restoring the structural integrity of the cornea in advanced keratoglobus while preserving the host limbal stem cells.

scholarly journals Structural integrity of rotator cuff at 16 years following repair: good long-term outcomes despite recurrent tears

2017 ◽  
Vol 11 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Robert S. J. Elliott ◽  
Yi-Jia Lim ◽  
Jennifer Coghlan ◽  
John Troupis ◽  
Simon Bell
Keyword(s):  
Los Angeles ◽  
Rotator Cuff ◽  
Clinical Outcomes ◽  
Structural Integrity ◽  
Case Series ◽  
Simple Shoulder Test ◽  
Supraspinatus Tear ◽  
Long Term Follow Up

Background There are few studies reporting long-term rotator cuff integrity following repair. The present study reports a case series of surgically repaired supraspinatus tendons followed up with clinical outcomes and ultrasound imaging after an average of 16 years. Methods The prospectively studied clinical outcomes at short-, medium- and long-term follow-up in 27 shoulders in 25 patients treated with arthroscopic subacromial decompression and mini-open rotator cuff repair have been reported previously. The functional outcomes scores recorded were the University of California Los Angeles (UCLA), American Shoulder and Elbow Surgeons (ASES) and Simple Shoulder Test (SST) measures. These patients then underwent an ultrasound scan with respect to the long-term assessment of the shoulder and the integrity of the repair. Results A recurrent tear was noted in 37% of patients at 16.25 years after surgery, of which 50% were small. Two patients required repeat surgery. Patients had a mean UCLA score of 30, an ASES score of 91.3 and a SST score of 9.5 with a 85% level of satisfaction with surgery. Patients with a recurrent tear had outcome scores equivalent to those with an intact cuff with no significant pain. No independent risk factors were identified as predictors for recurrent tear. Conclusions Patients showed sustained benefit and satisfaction at long-term follow-up despite a 37% recurrence of full-thickness supraspinatus tear.

Advances on NDT Methods and Technologies for Early Stage Diagnosis of Materials

2011 ◽  
Vol 681 ◽  
pp. 461-467 ◽  
Author(s):  
Giovanni Berti ◽  
Francesco De Marco ◽  
S. Aldrighetti
Keyword(s):  
Structural Integrity ◽  
New Technologies ◽  
Early Stage ◽  
Past Century ◽  
X Ray Diffraction ◽  
The Past ◽  
Atomic Flux ◽  
Investigation Methods ◽  
Significant Step

The early stage diagnoses of material lattices is becoming a crucial requirement where investigation methods and technologies are faced with both aging of components and materials. The mixing effects of wear, fatigue, temperature variation and environment conditions translate into variations of the atomic flux rate and internal rearrangement of grain size and boundaries of lattices. The related lattice measurements (e.g. the d-.spacing is one important among others) become the only one usable for early stage diagnoses of the lattice structural integrity. When such a diagnoses are the base to identify the qualification of material for the use or the re-qualification for the maintenance in the use, new technologies are required, with methods and appropriate concepts shall be used. The authors bid here to describe shortly the historical evolution of methods and techniques since the 70’s, along with the basic tests performed during the early 90’s of the past century. The technological follow up from those tests is reported along with some results which indicate the significant step up of the most recent technology toward the early stage diagnosis of material via on site x-ray diffraction. Further foreseeable development and advances are also mentioned.

scholarly journals Management of radiation-related supraglottic stenosis with serial in-office steroid injections

2018 ◽  
Vol 5 (1) ◽  
pp. 184
Author(s):  
Christine M. Kim ◽  
Pratik B. Patel ◽  
Aaron J. Feinstein ◽  
Dinesh K. Chhetri
Keyword(s):  
Head And Neck ◽  
Paradigm Shift ◽  
Surgical Intervention ◽  
Outpatient Management ◽  
Clinical Protocol ◽  
Steroid Injections ◽  
Clinical Challenge ◽  
History Of ◽  
Head And Neck Radiation

<p class="abstract">Management of supraglottic stenosis in patients with history of head and neck radiation presents a clinical challenge for otolaryngologists. The cornerstone of treatment has historically been surgical intervention, both endoscopic and open. However, recently described techniques related to outpatient management of subglottic and tracheal stenosis with routine in-office steroid injections may provide a translatable model for supraglottic stenosis management.<strong> </strong>We describe a clinical protocol for in-office steroid injections to the laryngopharynx for patients with supraglottic stenosis secondary to radiation fibrosis.<strong> </strong>Two patient cases are reported, including endoscopic examinations over a follow-up period of 12 to 16 months. Both patients experienced significant improvement in their supraglottic airways. In-office steroid injections may be beneficial to prevent or slow stenosis recurrence in patients treated with radiation for head and neck cancer. With continued refinement of this technique, a paradigm shift may occur in the management of supraglottic stenosis.</p>

scholarly journals Pan-cancer in silico analysis of somatic mutations in G-protein coupled receptors: The effect of evolutionary conservation and natural variance

2021 ◽  
Author(s):  
Brandon J Bongers ◽  
Marina Gorostiola González ◽  
Xuesong Wang ◽  
Herman WT van Vlijmen ◽  
Willem Jespers ◽  
...  
Keyword(s):  
G Protein ◽  
Structural Integrity ◽  
In Silico Analysis ◽  
G Protein Coupled Receptors ◽  
Dry Motif ◽  
Synthetic Ligand ◽  
Natural Variance ◽  
G Protein Coupled ◽  
Pan Cancer

G protein-coupled receptors (GPCRs) form the most frequently exploited drug target family, moreover they are often found mutated in cancer. Here we used an aggregated dataset of mutations found in cancer patient samples derived from the Genomic Data Commons and compared it to the natural human variance as exemplified by data from the 1000 Genomes project. While the location of these mutations across the protein domains did not differ significantly in the two datasets, a mutation enrichment was observed in cancer patients among conserved residues in GPCRs such as the 'DRY' motif. We subsequently created a ranking of high scoring GPCRs, using a multi-objective approach (Pareto Front Ranking). The validity of our approach was confirmed by re-discovery of established cancer targets such as the LPA and mGlu receptor families, and we identified novel GPCRs that had not been directly linked to cancer before such as the P2Y Receptor 10 (P2RY10). As a proof of concept, we projected the structurally investigated mutations in the crystal structure of the C-C Chemokine (CCR) 5 receptor, one of the high-ranking GPCRs previously linked to cancer. Several positions were pinpointed that relate to either structural integrity or endogenous and synthetic ligand binding, providing a rationale to their mechanism of influence in cancer. In conclusion, this study identifies a list of GPCRs that are prioritized for experimental follow up characterization to elucidate their role in cancer. The computational approach here described can be adapted to investigate the roles in cancer of any protein family.

Subscapularis structural integrity and function after arthroscopic Latarjet procedure at a minimum 2-year follow-up

2020 ◽  
Vol 29 (1) ◽  
pp. 104-112 ◽  
Author(s):  
María Valencia ◽  
Gloria Fernández-Bermejo ◽  
María D. Martín-Ríos ◽  
Javier Fernández-Jara ◽  
Diana Morcillo-Barrenechea ◽  
...  
Keyword(s):  
Structural Integrity ◽  
Latarjet Procedure ◽  
Arthroscopic Latarjet ◽  
Arthroscopic Latarjet Procedure ◽  
And Function
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