scholarly journals Research Article Association of HLA-G 14-base pair insertion/deletion polymorphism with breast cancer in Saudi Arabia

2019 ◽  
Vol 18 (2) ◽  
Author(s):  
S.Y. Al Omar ◽  
L. Mansour
Keyword(s):  
Breast Cancer ◽  
Saudi Arabia ◽  
Base Pair ◽  
Deletion Polymorphism ◽  
Research Article ◽  
G 14 ◽  
Base Pair Insertion

Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There an Association with Severe Obesity and Weight Loss in Morbidly Obese Subjects?

2012 ◽  
Vol 10 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Dimitrios Papazoglou ◽  
Pantelis Papathanasiou ◽  
Nikolaos Papanas ◽  
Konstantinos Papatheodorou ◽  
Eleni Chatziangeli ◽  
...  
Keyword(s):  
Weight Loss ◽  
Base Pair ◽  
Severe Obesity ◽  
Uncoupling Protein ◽  
Morbidly Obese ◽  
Uncoupling Protein 2 ◽  
Deletion Polymorphism ◽  
Obese Subjects ◽  
Base Pair Insertion

scholarly journals A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users

2007 ◽  
Vol 85 (4) ◽  
pp. 1098-1102 ◽  
Author(s):  
Xinran Xu ◽  
Marilie D Gammon ◽  
James G Wetmur ◽  
Manlong Rao ◽  
Mia M Gaudet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dihydrofolate Reductase ◽  
Base Pair ◽  
Deletion Polymorphism ◽  
Base Pair Deletion

scholarly journals Elevation of plasma-soluble HLA-G in childhood nephrotic syndrome is associated with IgE

2016 ◽  
Vol 54 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Yanqing Liu ◽  
Meimei Lai ◽  
Yunyan Lou ◽  
Qiuyue Han ◽  
Qing Yang ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Human Leukocyte Antigen ◽  
Base Pair ◽  
Immunoglobulin E ◽  
Human Leukocyte ◽  
Deletion Polymorphism ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
Normal Controls ◽  
Base Pair Insertion

Background Nephrotic syndrome is related to immune system dysfunction. Soluble human leukocyte antigen-G has been suggested to have an immunomodulatory role. Additionally, human leukocyte antigen-G expression may be influenced by the 14-base pair insertion/deletion polymorphism. However, this molecule has not been investigated in nephrotic syndrome. Methods Fifty-five children with nephrotic syndrome were enrolled: 24 primary nephrotic syndrome patients and 31 recurrent nephrotic syndrome patients. A group of 120 healthy subjects were included as reference controls. Additionally, 22 patients in nephrotic syndrome remission after treatments were also included. Both nephrotic syndrome patients and healthy subjects were genotyped for the 14-base pair insertion/deletion polymorphism. Plasma soluble human leukocyte antigen-G concentrations and serum immunoglobulin concentrations were determined. Results Nephrotic syndrome patients showed significantly higher levels of both soluble human leukocyte antigen-G and immunoglobulin E compared to normal controls. Nephrotic syndrome patients presented a higher frequency of the −14-base pair allele than did normal controls. Soluble human leukocyte antigen-G concentrations in remission patients were dramatically lower compared to in nephrotic syndrome patients. Moreover, soluble human leukocyte antigen-G and immunoglobulin E were moderately correlated in nephrotic syndrome patients. Conclusions The present study demonstrated that plasma soluble human leukocyte antigen-G concentrations were significantly elevated and that a relationship between serum total immunoglobulin E in nephrotic syndrome patients and the human leukocyte antigen-G −14-base pair allele may be a risk factor for nephrotic syndrome. These findings suggest that soluble human leukocyte antigen-G may be used as a monitoring marker for nephrotic syndrome patients' condition.

Lack of association between 4-base pair insertion/deletion (rs3783553) polymorphism within the 3′UTR of IL1A and breast cancer: A preliminary report

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101067
Author(s):  
Shima Karami ◽  
Sahel Sarabandi ◽  
Pouria Pourzand ◽  
Farhad Tabasi ◽  
Mohammad Hashemi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Base Pair ◽  
Preliminary Report ◽  
Base Pair Insertion

The role of primary care centers in Saudi Arabia in the early detection of breast cancer

2019 ◽  
pp. 620-624
Author(s):  
Saad Alhumaidi ◽  
Abdullah Alshehri ◽  
Abdullah Altowairqi ◽  
Ahmad Alharthy ◽  
Bader Malki
Keyword(s):  
Breast Cancer ◽  
Primary Care ◽  
Saudi Arabia ◽  
Early Detection

IS tRNA DRIVING BREAST CANCER PROGRESSION?

2019 ◽  
Author(s):  
Zil-e- Rubab
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Developing Countries ◽  
Molecular Mechanism ◽  
Cancer Progression ◽  
Critical Review ◽  
Driving Forces ◽  
Treatment Modalities ◽  
Critical Research ◽  
Research Article

This critical research periodical is mainly based on critical review of research article titled ‘Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression published in Cell by Goodarzi et al1. According to Globocan, 2008 report2, breast is among the leading site of new cancer cases and deaths (691,300/268,900) in females of developing countries and second leading site in USA (Globocan, 2012)3. The extensive research is in progress on different aspects of molecular mechanism of driving forces and different treatment modalities to ease this burden. The above mentioned research article is also part of this effort.

scholarly journals The Level of Lymphedema Awareness among Women with Breast Cancer in the Kingdom of Saudi Arabia

2021 ◽  
Vol 18 (2) ◽  
pp. 627
Author(s):  
Fatmah Alsharif ◽  
Wedad Almutairi ◽  
Faygah Shibily ◽  
Fatmah Alhothari ◽  
Fidaa Batwa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Saudi Arabia ◽  
Soft Tissues ◽  
Demographic Data ◽  
Medical Team ◽  
Online Questionnaire ◽  
Kingdom Of Saudi Arabia ◽  
Cross Sectional ◽  
Convenience Sample ◽  
The Status

Background: Lymphedema is a condition in which excessive fluid accumulates in soft tissues. It is a common complication of breast cancer treatments. It can lead to serious consequences and interfere with the activity of daily living. This study aimed to determine the level of awareness of breast-cancer-related lymphedema (BCRL) among women with breast cancer in the Kingdom of Saudi Arabia. This was a descriptive quantitative cross-sectional design that included a convenience sample of women diagnosed with breast cancer in the Kingdom of Saudi Arabia. Data were collected by distributing a self-administrated online questionnaire consisting of four parts, including demographic data (five items), the status of education about BCRL (three items), basic medical history of breast cancer (six items), and BCRL level of awareness of risk factors and management (nine items). Results: In total, 95 out of 135 of participants did not know about lymphedema, 119 of the participants (88.1%) did not receive any explanation about the possibility of lymphedema from their medical team before surgery, and 121 of them (89.6%) did not receive it after surgery. The most significant factor affecting participants’ level of awareness regarding BCRL was the lack of information about the possibility of BCRL occurrence, which was not provided to them by the medical team. Recommendation: Early and continuous education for future management is essential to prevent problems related to BCRL and improve quality of life.

The HLA-G 14-base pair deletion allele and the deletion/deletion genotype are associated with persistent HBe antigenemia in chronic hepatis B infection

2017 ◽  
Vol 78 (2) ◽  
pp. 166-171 ◽  
Author(s):  
Sandro da Costa Ferreira ◽  
Silvana Gama Florêncio Chachá ◽  
Fernanda Fernandes Souza ◽  
Andreza Corrêa Teixeira ◽  
Rodrigo de Carvalho Santana ◽  
...  
Keyword(s):  
Base Pair ◽  
Deletion Allele ◽  
Base Pair Deletion ◽  
G 14
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