Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There an Association with Severe Obesity and Weight Loss in Morbidly Obese Subjects?

2012 ◽  
Vol 10 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Dimitrios Papazoglou ◽  
Pantelis Papathanasiou ◽  
Nikolaos Papanas ◽  
Konstantinos Papatheodorou ◽  
Eleni Chatziangeli ◽  
...  
Keyword(s):  
Weight Loss ◽  
Base Pair ◽  
Severe Obesity ◽  
Uncoupling Protein ◽  
Morbidly Obese ◽  
Uncoupling Protein 2 ◽  
Deletion Polymorphism ◽  
Obese Subjects ◽  
Base Pair Insertion

A 45-bp Insertion/Deletion Polymorphism in Uncoupling Protein 2 is Not Associated with Obesity in a Chinese Population

2012 ◽  
Vol 50 (9-10) ◽  
pp. 784-796 ◽  
Author(s):  
Xiaoqiu Liu ◽  
Bin Zhang ◽  
Xin Liu ◽  
Yue Shen ◽  
Jiana Li ◽  
...  
Keyword(s):  
Chinese Population ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Deletion Polymorphism

Effect of weight loss on muscle lipid content in morbidly obese subjects

2003 ◽  
Vol 284 (4) ◽  
pp. E726-E732 ◽  
Author(s):  
Robert E. Gray ◽  
Charles J. Tanner ◽  
Walter J. Pories ◽  
Kenneth G. MacDonald ◽  
Joseph A. Houmard
Keyword(s):  
Weight Loss ◽  
Insulin Action ◽  
Fiber Type ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Type I ◽  
Fiber Types ◽  
Model Assessment ◽  
Before And After ◽  
Obese Subjects

The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m2; n= 6] before and after gastric bypass surgery, an intervention that improves insulin action. With intervention, there was a 47% reduction ( P < 0.01) in BMI and a 93% decrease in homeostasis model assessment, or HOMA (7.0 ± 1.9 vs. 0.5 ± 0.1). Histochemically determined IMCL content decreased ( P < 0.05) by ∼30%. In relation to fiber type, IMCL was significantly higher in type I vs. type II fibers. In both fiber types, there were reductions in IMCL and trends for muscle atrophy. Despite these two negating factors, the IMCL-to-fiber area ratio still decreased by ∼44% with weight loss. In conclusion, despite differing initial levels and possible atrophy, weight loss appears to decrease IMCL deposition to a similar relative extent in type I and II muscle fibers. This reduction in intramuscular triglyceride may contribute to enhanced insulin action seen with weight loss.

scholarly journals Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

2012 ◽  
Vol 97 (7) ◽  
pp. E1229-E1233 ◽  
Author(s):  
G. H. E. J. Vijgen ◽  
N. D. Bouvy ◽  
G. J. J. Teule ◽  
B. Brans ◽  
J. Hoeks ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Morbidly Obese ◽  
Brown Adipose ◽  
Obese Subjects ◽  
Brown Adipose Tissue Activity

Weight Loss and Metabolic Improvement in Morbidly Obese Subjects Implanted for 1 Year With an Endoscopic Duodenal-Jejunal Bypass Liner

2012 ◽  
Vol 255 (6) ◽  
pp. 1080-1085 ◽  
Author(s):  
Alex Escalona ◽  
Fernando Pimentel ◽  
Allan Sharp ◽  
Pablo Becerra ◽  
Milenko Slako ◽  
...  
Keyword(s):  
Weight Loss ◽  
Morbidly Obese ◽  
Obese Subjects ◽  
Jejunal Bypass

scholarly journals The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fabian Schulte ◽  
Abdul Aziz Asbeutah ◽  
Peter N. Benotti ◽  
G. Craig Wood ◽  
Christopher Still ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
White Blood Cells ◽  
Diabetes Remission ◽  
Lipid Mediators ◽  
Morbidly Obese ◽  
Post Surgery ◽  
Obesity And Diabetes ◽  
Obese Subjects

AbstractObesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)—resolvins (Rv), protectins (PD) and maresins (MaR)—actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs—RvD3, RvD4 and PD1—and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease (p = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.

Relationship between sympathetic reactivity and body weight loss in morbidly obese subjects

2004 ◽  
Vol 28 (7) ◽  
pp. 906-911 ◽  
Author(s):  
E Bobbioni-Harsch ◽  
O Bongard ◽  
F Habicht ◽  
D Weimer ◽  
H Bounameaux ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Body Weight Loss ◽  
Morbidly Obese ◽  
Obese Subjects

Circulating Peptide YY, Weight Loss, and Glucose Homeostasis After Gastric Bypass Surgery in Morbidly Obese Subjects

2008 ◽  
Vol 247 (2) ◽  
pp. 270-275 ◽  
Author(s):  
Rosa Morínigo ◽  
Josep Vidal ◽  
Antonio M. Lacy ◽  
Salvadora Delgado ◽  
Roser Casamitjana ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Glucose Homeostasis ◽  
Bypass Surgery ◽  
Peptide Yy ◽  
Gastric Bypass Surgery ◽  
Morbidly Obese ◽  
Obese Subjects
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