scholarly journals Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway

2016 ◽  
Vol 15 (4) ◽  
Author(s):  
Y. He ◽  
C.X. Jian ◽  
H.Y. Zhang ◽  
Y. Zhou ◽  
X. Wu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Signaling Pathway ◽  
Periodontal Ligament ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Stem Cell Proliferation ◽  
Periodontal Ligament Stem Cell

LncRNA MAFG‐AS1 regulates human periodontal ligament stem cell proliferation and Toll‐like receptor 4 expression

Oral Diseases ◽  
2020 ◽  
Vol 26 (6) ◽  
pp. 1302-1307 ◽  
Author(s):  
Kaixin Wangzhou ◽  
Lei Gong ◽  
Cheng Liu ◽  
Yi Tan ◽  
Jingxin Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Periodontal Ligament ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Stem Cell Proliferation ◽  
Periodontal Ligament Stem Cell

scholarly journals miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway

2018 ◽  
Vol 26 (3) ◽  
pp. 363-372 ◽  
Author(s):  
Xiaowen Chen ◽  
Jianli Chen
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Molecular Mechanisms ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Luciferase Reporter ◽  
And Migration ◽  
Mcf 7

This study intended to investigate the effects of miR-3188 on breast cancer and to reveal the possible molecular mechanisms. miR-3188 was upregulated and TUSC5 was downregulated in breast cancer tissues and MCF-7 cells compared to normal tissue and MCF-10 cells. After MCF-7 cells were transfected with miR-3188 inhibitor, cell proliferation and migration were inhibited, whereas apoptosis was promoted. Luciferase reporter assay suggested that TUSC5 was a target gene of miR-3188. In addition, miR-3188 overexpression increased the p-p38 expression, while miR-3188 suppression decreased the p-p38 expression significantly. miR-3188 regulated breast cancer progression via the p38 MAPK signaling pathway. In conclusion, miR-3188 affects breast cancer cell proliferation, apoptosis, and migration by targeting TUSC5 and activating the p38 MAPK signaling pathway. miR-3188 may serve as a potential therapeutic agent for the treatment of breast cancer.

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