scholarly journals The role of the hedgehog/patched signaling pathway in epithelial stem cell proliferation: from fly to human

Cell Research ◽  
1998 ◽  
Vol 8 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Michael J Parisi ◽  
Haifan Lin
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Proliferation ◽  
Epithelial Stem Cell

A Novel Role of Autophagy in Intestinal Epithelial Stem Cell Proliferation and Renewal

2014 ◽  
Vol 186 (2) ◽  
pp. 650 ◽  
Author(s):  
S. Shaffiey ◽  
C. Sodhi ◽  
H. Jia ◽  
M. Good ◽  
M. Neal ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Intestinal Epithelial ◽  
Stem Cell Proliferation ◽  
Epithelial Stem Cell

scholarly journals Sex differences influence intestinal epithelial stem cell proliferation independent of obesity

2018 ◽  
Vol 6 (13) ◽  
pp. e13746 ◽  
Author(s):  
Weinan Zhou ◽  
Elizabeth A. Davis ◽  
Kailiang Li ◽  
Romana A. Nowak ◽  
Megan J. Dailey
Keyword(s):  
Cell Proliferation ◽  
Sex Differences ◽  
Stem Cell ◽  
Intestinal Epithelial ◽  
Stem Cell Proliferation ◽  
Epithelial Stem Cell

scholarly journals CD44 and TLR4 mediate hyaluronic acid regulation of Lgr5+ stem cell proliferation, crypt fission, and intestinal growth in postnatal and adult mice

2015 ◽  
Vol 309 (11) ◽  
pp. G874-G887 ◽  
Author(s):  
Terrence E. Riehl ◽  
Srikanth Santhanam ◽  
Lynne Foster ◽  
Matthew Ciorba ◽  
William F. Stenson
Keyword(s):  
Cell Proliferation ◽  
Small Intestine ◽  
Stem Cell ◽  
Hyaluronic Acid ◽  
Postnatal Life ◽  
Epithelial Proliferation ◽  
Stem Cell Proliferation ◽  
Crypt Fission ◽  
Intestinal Length

Hyaluronic acid, a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously addressed the role of hyaluronic acid in small intestinal and colonic growth in mice. We addressed the role of exogenous hyaluronic acid by giving hyaluronic acid intraperitoneally and the role of endogenous hyaluronic acid by giving PEP-1, a peptide that blocks hyaluronic acid binding to its receptors. Exogenous hyaluronic acid increased epithelial proliferation but had no effect on intestinal length. PEP-1 resulted in a shortened small intestine and colon and diminished epithelial proliferation. In the current study, we sought to determine whether the effects of hyaluronic acid on growth were mediated by signaling through CD44 or TLR4 by giving exogenous hyaluronic acid or PEP-1 twice a week from 3–8 wk of age to wild-type, CD44−/−, and TLR4−/− mice. These studies demonstrated that signaling through both CD44 and TLR4 were important in mediating the effects of hyaluronic acid on growth in the small intestine and colon. Extending our studies to early postnatal life, we assessed the effects of exogenous hyaluronic acid and PEP-1 on Lgr5+ stem cell proliferation and crypt fission. Administration of PEP-1 to Lgr5+ reporter mice from postnatal day 7 to day 14 decreased Lgr5+ cell proliferation and decreased crypt fission. These studies indicate that endogenous hyaluronic acid increases Lgr5+ stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 and TLR4.

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