scholarly journals Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits

2014 ◽  
Vol 13 (2) ◽  
pp. 4599-4606 ◽  
Author(s):  
Z.J. Wang ◽  
R.Z. An ◽  
J.Y. Zhao ◽  
Q. Zhang ◽  
J. Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Defects ◽  
Adipose Derived Stem Cells ◽  
Cartilaginous Matrix ◽  
Engineered Cartilage ◽  
Articular Cartilage Defects

scholarly journals Chondrogenic Differentiation of Human Adipose-Derived Stem Cells: A New Path in Articular Cartilage Defect Management?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jan-Philipp Stromps ◽  
Nora Emilie Paul ◽  
Björn Rath ◽  
Mahtab Nourbakhsh ◽  
Jürgen Bernhagen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
Adipose Derived Stem Cells ◽  
Age Related ◽  
Healthy Cartilage ◽  
Control And Prevention ◽  
Articular Cartilage Defects

According to data published by the Centers for Disease Control and Prevention, over 6 million people undergo a variety of medical procedures for the repair of articular cartilage defects in the U.S. each year. Trauma, tumor, and age-related degeneration can cause major defects in articular cartilage, which has a poor intrinsic capacity for healing. Therefore, there is substantial interest in the development of novel cartilage tissue engineering strategies to restore articular cartilage defects to a normal or prediseased state. Special attention has been paid to the expansion of chondrocytes, which produce and maintain the cartilaginous matrix in healthy cartilage. This review summarizes the current efforts to generate chondrocytes from adipose-derived stem cells (ASCs) and provides an outlook on promising future strategies.

scholarly journals A composite scaffold of Wharton’s jelly and chondroitin sulphate loaded with human umbilical cord mesenchymal stem cells repairs articular cartilage defects in rat knee

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Zhong Li ◽  
Yikang Bi ◽  
Qi Wu ◽  
Chao Chen ◽  
Lu Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Composite Scaffold ◽  
Biomechanical Properties ◽  
Cartilage Defects ◽  
Human Umbilical Cord ◽  
Composite Scaffolds ◽  
Articular Cartilage Defects

AbstractTo evaluate the performance of a composite scaffold of Wharton’s jelly (WJ) and chondroitin sulfate (CS) and the effect of the composite scaffold loaded with human umbilical cord mesenchymal stem cells (hUCMSCs) in repairing articular cartilage defects, two experiments were carried out. The in vitro experiments involved identification of the hUCMSCs, construction of the biomimetic composite scaffolds by the physical and chemical crosslinking of WJ and CS, and testing of the biomechanical properties of both the composite scaffold and the WJ scaffold. In the in vivo experiments, composite scaffolds loaded with hUCMSCs and WJ scaffolds loaded with hUCMSCs were applied to repair articular cartilage defects in the rat knee. Moreover, their repair effects were evaluated by the unaided eye, histological observations, and the immunogenicity of scaffolds and hUCMSCs. We found that in vitro, the Young’s modulus of the composite scaffold (WJ-CS) was higher than that of the WJ scaffold. In vivo, the composite scaffold loaded with hUCMSCs repaired rat cartilage defects better than did the WJ scaffold loaded with hUCMSCs. Both the scaffold and hUCMSCs showed low immunogenicity. These results demonstrate that the in vitro construction of a human-derived WJ-CS composite scaffold enhances the biomechanical properties of WJ and that the repair of knee cartilage defects in rats is better with the composite scaffold than with the single WJ scaffold if the scaffold is loaded with hUCMSCs.

Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects

2014 ◽  
pp. 87-97
Author(s):  
Andrea Preitschopf ◽  
Julia Busch ◽  
Hannes Zwickl ◽  
Stefan Nehrer ◽  
Markus Hengstschläger ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Amniotic Fluid ◽  
Cartilage Defects ◽  
Amniotic Fluid Stem Cells ◽  
Articular Cartilage Defects

Repair of Articular Cartilage Defects Using Mesenchymal Stem Cells

1995 ◽  
Vol 1 (4) ◽  
pp. 345-353 ◽  
Author(s):  
Daniel A. Grande ◽  
Sheila S. Southerland ◽  
Ryhanna Manji ◽  
Donald W. Pate ◽  
Robert E. Schwartz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Defects ◽  
Articular Cartilage Defects

Effects of Photobiomodulation and Mesenchymal Stem Cells on Articular Cartilage Defects in a Rabbit Model

2016 ◽  
Vol 34 (11) ◽  
pp. 543-549 ◽  
Author(s):  
Reza Fekrazad ◽  
Mohamadreza Baghaban Eslaminejad ◽  
Arman M. Shayan ◽  
Katayoun A.M. Kalhori ◽  
Fatemeh Mashhadi Abbas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Rabbit Model ◽  
Cartilage Defects ◽  
Articular Cartilage Defects
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