scholarly journals Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China

2012 ◽  
Vol 11 (4) ◽  
pp. 4330-4341 ◽  
Author(s):  
M.-Y. Sun ◽  
X.-X. Yang ◽  
W.-W. Xu ◽  
G.-Y. Yao ◽  
H.-Z. Pan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
South China ◽  
Chinese Women ◽  
Han Chinese

scholarly journals Associations of Genetic Variants at Nongenic Susceptibility Loci with Breast Cancer Risk and Heterogeneity by Tumor Subtype in Southern Han Chinese Women

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Huiying Liang ◽  
Hong Li ◽  
Xuexi Yang ◽  
Lujia Chen ◽  
Anna Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Triple Negative ◽  
Chinese Women ◽  
Intrinsic Subtype ◽  
Han Chinese ◽  
Susceptibility Loci ◽  
Luminal A ◽  
Luminal B

Current understanding of cancer genomes is mainly “gene centric.” However, GWAS have identified some nongenic breast cancer susceptibility loci. Validation studies showed inconsistent results among different populations. To further explore this inconsistency and to investigate associations by intrinsic subtype (Luminal-A, Luminal-B, ER−&PR−&HER2+, and triple negative) among Southern Han Chinese women, we genotyped five nongenic polymorphisms (2q35: rs13387042, 5p12: rs981782 and rs4415084, and 8q24: rs1562430 and rs13281615) using MassARRAY IPLEX platform in 609 patients and 882 controls. Significant associations with breast cancer were observed for rs13387042 and rs4415084 with OR (95% CI) per-allele 1.29 (1.00–1.66) and 0.83 (0.71–0.97), respectively. In subtype specific analysis, rs13387042 (per-allele adjusted OR = 1.36, 95% CI = 1.00–1.87) and rs4415084 (per-allele adjusted OR = 0.82, 95% CI = 0.66–1.00) showed slightly significant association with Luminal-A subtype; however, only rs13387042 was associated with ER−&PR−&HER2+ tumors (per-allele adjusted OR = 1.55, 95% CI = 1.00–2.40), and none of them were linked to Luminal-B and triple negative subtype. Collectively, nongenic SNPs were heterogeneous according to the intrinsic subtype. Further studies with larger datasets along with intrinsic subtype categorization should explore and confirm the role of these variants in increasing breast cancer risk.

Association of polymorphisms in intron 2 of FGFR2 and breast cancer risk in Chinese women

2016 ◽  
Vol 50 (5) ◽  
pp. 312-317 ◽  
Author(s):  
Z. Pan ◽  
Y. Bao ◽  
X. Zheng ◽  
W. Cao ◽  
W. Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Intron 2

Associations between polymorphisms at microRNA-binding sites in TYMS and breast cancer risk among Chinese women

2020 ◽  
Author(s):  
Meng Wang ◽  
Jia Yao ◽  
Yi Zheng ◽  
Yuyao Yao ◽  
Shuqian Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Microarray Dataset ◽  
Tumor Stage ◽  
Recessive Model ◽  
Breast Cancer Patients ◽  
Chinese Han ◽  
Expression Levels

Abstract Studies have suggested that thymidylate (TYMS) polymorphisms are associated with breast cancer. However, inconsistent results were obtained and data from Asian populations are largely lacking. In this study, the relationships between two common TYMS polymorphisms (rs2790 and rs1059394) and the breast cancer risk were evaluated. We also studied the TYMS expression between tumor and para-carcinoma tissues, and the association between TYMS levels and prognosis of breast cancer. This hospital-based study included 434 patients and 450 cancer-free individuals. Genotying was performed using Sequenom Mass-ARRAY. The microarray dataset GSE115144 was downloaded to compare the differences in TYMS expression between tumor and para-carcinoma tissues. The microarray dataset GSE20685 was used to analysis the metastasis free survival (MFS) and overall survival (OS) of patients. The rs2790 polymorphism was related to a higher risk of breast cancer (recessive model: OR=1.50, 95%CI=1.02-2.21, P=0.038) and the C allele of rs1059394 was overrepresented in patients with tumor stage III-IV (heterozygote model: OR=0.60, 95%CI=0.39-0.94, P=0.025; dominant model: OR=0.59, 95%CI=0.39-0.89, P=0.013). The tumor tissues had a higher TYMS expression levels and patients with higher TYMS expression levels had worse OS. Overall, TYMS polymorphism may increase susceptibility to breast cancer in Chinese Han women and TYMS expression levels may be a predictive factor for breast cancer patients.

Plasma sex steroid hormones and breast cancer risk in Chinese women

2003 ◽  
Vol 105 (1) ◽  
pp. 92-97 ◽  
Author(s):  
Herbert Yu ◽  
Xiao-Ou Shu ◽  
Runhua Shi ◽  
Qi Dai ◽  
Fan Jin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Chinese Women ◽  
Sex Steroid Hormones ◽  
Sex Steroid

Abstract 891: Association of genetic polymorphisms of SIPA1 with breast cancer risk and survival among Chinese women

2010 ◽  
Author(s):  
Shimian Qu ◽  
Hui Cai ◽  
Jirong Long ◽  
Qiuyin Cai ◽  
Regina Courtney ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Chinese Women

Body composition patterns and breast cancer risk in Chinese women with breast diseases: A latent class analysis

2019 ◽  
Vol 75 (11) ◽  
pp. 2638-2646
Author(s):  
Jinyu Zhang ◽  
Jichuan Wang ◽  
Jie Zhou ◽  
Qiong Fang ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Composition ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Latent Class Analysis ◽  
Latent Class ◽  
Chinese Women ◽  
Breast Diseases ◽  
Class Analysis
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