Plasma sex steroid hormones and breast cancer risk in Chinese women

2003 ◽  
Vol 105 (1) ◽  
pp. 92-97 ◽  
Author(s):  
Herbert Yu ◽  
Xiao-Ou Shu ◽  
Runhua Shi ◽  
Qi Dai ◽  
Fan Jin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Chinese Women ◽  
Sex Steroid Hormones ◽  
Sex Steroid

scholarly journals Linking physical activity to breast cancer via sex steroid hormones Part 2: The effect of sex steroid hormones on breast cancer risk

2021 ◽  
pp. cebp.0438.2021
Author(s):  
Ann E Drummond ◽  
Christopher T V Swain ◽  
Kristy A Brown ◽  
Suzanne C Dixon-Suen ◽  
Leonessa Boing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid

scholarly journals Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hui Zeng ◽  
Zhuoyu Yang ◽  
Jiang Li ◽  
Yan Wen ◽  
Zheng Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Steroid Hormones ◽  
Lung Cancer Risk ◽  
Meta Analysis ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Exposure ◽  
Female Lung Cancer

Abstract Background Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure specifically on the risk of lung cancer in women. Methods The PubMed, MEDLINE, Web of Science, and EMBASE databases were searched. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for female lung cancer risk associated with sex steroid hormones were calculated overall and by study design, publication year, population, and smoking status. Sensitivity analysis, publication bias, and subgroup analysis were performed. Results Forty-eight studies published between 1987 and 2019 were included in the study with a total of 31,592 female lung cancer cases and 1,416,320 subjects without lung cancer. Overall, higher levels of sex steroid hormones, both endogenous (OR: 0.92, 95% CI: 0.87–0.98) and exogenous (OR: 0.86, 95% CI: 0.80–0.93), significantly decreased the risk of female lung cancer by 10% (OR: 0.90, 95% CI: 0.86–0.95). The risk of lung cancer decreased more significantly with a higher level of sex steroid hormones in non-smoking women (OR: 0.88, 95% CI: 0.78–0.99) than in smoking women (OR: 0.98, 95% CI: 0.77–1.03), especially in Asia women (OR: 0.84, 95% CI: 0.74–0.96). Conclusions Our meta-analysis reveals an association between higher levels of sex steroid hormone exposure and the decreased risk of female lung cancer. Surveillance of sex steroid hormones might be used for identifying populations at high risk for lung cancer, especially among non-smoking women.

scholarly journals A Metabolomics Analysis of Postmenopausal Breast Cancer Risk in the Cancer Prevention Study II

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 95
Author(s):  
Steven C. Moore ◽  
Kaitlyn M. Mazzilli ◽  
Joshua N. Sampson ◽  
Charles E. Matthews ◽  
Brian D. Carter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Conditional Logistic Regression ◽  
Postmenopausal Breast Cancer ◽  
Sex Steroid ◽  
Birth Date ◽  
Blood Draw ◽  
Metabolomics Analysis

Breast cancer is the most common cancer in women, but its incidence can only be partially explained through established risk factors. Our aim was to use metabolomics to identify novel risk factors for breast cancer and to validate recently reported metabolite-breast cancer findings. We measured levels of 1275 metabolites in prediagnostic serum in a nested case-control study of 782 postmenopausal breast cancer cases and 782 matched controls. Metabolomics analysis was performed by Metabolon Inc using ultra-performance liquid chromatography and a Q-Exactive high resolution/accurate mass spectrometer. Controls were matched by birth date, date of blood draw, and race/ethnicity. Odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer at the 90th versus 10th percentile (modeled on a continuous basis) of metabolite levels were estimated using conditional logistic regression, with adjustment for age. Twenty-four metabolites were significantly associated with breast cancer risk at a false discovery rate <0.20. For the nine metabolites positively associated with risk, the ORs ranged from 1.75 (95% CI: 1.29–2.36) to 1.45 (95% CI: 1.13–1.85), and for the 15 metabolites inversely associated with risk, ORs ranged from 0.59 (95% CI: 0.43–0.79) to 0.69 (95% CI: 0.55–0.87). These metabolites largely comprised carnitines, glycerolipids, and sex steroid metabolites. Associations for three sex steroid metabolites validated findings from recent studies and the remainder were novel. These findings contribute to growing data on metabolite-breast cancer associations by confirming prior findings and identifying novel leads for future validation efforts.

Sex steroid hormones, bone mass and breast cancer

1998 ◽  
Vol 7 ◽  
pp. S66
Author(s):  
J A Cauley ◽  
F Luas ◽  
L H Kuller ◽  
K Stone ◽  
S Cummings
Keyword(s):  
Breast Cancer ◽  
Bone Mass ◽  
Steroid Hormones ◽  
Sex Steroid Hormones ◽  
Sex Steroid

Association of polymorphisms in intron 2 of FGFR2 and breast cancer risk in Chinese women

2016 ◽  
Vol 50 (5) ◽  
pp. 312-317 ◽  
Author(s):  
Z. Pan ◽  
Y. Bao ◽  
X. Zheng ◽  
W. Cao ◽  
W. Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Intron 2
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