scholarly journals Evaluation of Cisplatin-Loaded Polymeric Micelles and Hybrid Nanoparticles Containing Poly(Ethylene Oxide)-Block-Poly(Methacrylic Acid) on Tumor Delivery

2016 ◽  
Vol 07 (01) ◽  
pp. 1-8 ◽  
Author(s):  
Andang Miatmoko ◽  
Kumi Kawano ◽  
Etsuo Yonemochi ◽  
Yoshiyuki Hattori
Keyword(s):  
Ethylene Oxide ◽  
Methacrylic Acid ◽  
Polymeric Micelles ◽  
Hybrid Nanoparticles ◽  
Tumor Delivery ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Biostable Poly(ethylene oxide)-b-poly(methacrylic acid) Micelles forpH-triggered Release of Doxorubicin

2011 ◽  
Vol 41 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Young-Keun Choi ◽  
Dong-Won Lee ◽  
Chul-Soon Yong ◽  
Han-Gon Choi ◽  
Tatiana K. Bronich ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Methacrylic Acid ◽  
Triggered Release ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Structure and Rheology of Mixed Polymeric Micelles Formed by Hydrophobically End-Capped Poly(ethylene oxide)

2008 ◽  
Vol 41 (17) ◽  
pp. 6523-6530 ◽  
Author(s):  
Frédéric Renou ◽  
Lazhar Benyahia ◽  
Taco Nicolai ◽  
Otto Glatter
Keyword(s):  
Ethylene Oxide ◽  
Polymeric Micelles ◽  
Poly Ethylene Oxide ◽  
Mixed Polymeric Micelles ◽  
Poly Ethylene

scholarly journals Pharmacokinetics of Orally Administered Poly(Ethylene Oxide)-block-Poly(ε-Caprolactone) Micelles of Cyclosporine A in Rats: Comparison with Neoral®

2018 ◽  
Vol 21 (1s) ◽  
pp. 177s-191s ◽  
Author(s):  
Ziyad Binkhathlan ◽  
Raisuddin Ali ◽  
Wajhul Qamar ◽  
Afsaneh Lavasanifar
Keyword(s):  
Ethylene Oxide ◽  
Oral Administration ◽  
Cyclosporine A ◽  
Oral Delivery ◽  
Polymeric Micelles ◽  
Simulated Gastric Fluid ◽  
Pharmacokinetic Parameters ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Time Point

PURPOSE: The aim of this study was to assess the pharmacokinetics of methoxy poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) micellar formulation of cyclosporine A (CyA) following oral administration in rats making comparisons with its commercial microemulsion formulation, Neoral®. METHODS: PEO-b-PCL copolymer was synthesized and used to form micelles encapsulating CyA. The release of CyA from Neoral® and PEO-b-PCL as well as PEO-b-PCL degradation were assessed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Polymeric micellar CyA and Neoral® were administered by oral gavage to healthy Wistar rats. At predetermined intervals, rats (n=5 for each time point) were euthanized, samples of blood and plasma were collected and analyzed for CyA using an LC-MS/MS assay. Blood and plasma pharmacokinetic parameters of CyA in its polymeric micellar formulation were compared to those of Neoral®. RESULTS: Polymeric micelles of CyA showed < 15 and 10% increase in diameter in SGF and SIF, respectively, within 24 h. PEO-b-PCL showed signs of minimal degradation when incubated for > 8 h in SGF, but was stable in SIF. Drug release in both SGF and SIF was comparable between the two formulations except for significantly higher release of CyA in SIF only at 24 h time point from Neoral®. Following oral administration (10 mg/kg), the blood AUC0-∞ and tmax of CyA in the polymeric micellar formulation was comparable to that for Neoral®. However, the Cmax of CyA-loaded PEO-b-PCL micelles was significantly (p < 0.05) higher than that obtained with Neoral® (2.10 ± 0.41 versus 1.40 ± 0.25 µg/mL, respectively). CyA had higher blood-to-plasma concentration ratios in polymeric micelles compared to Neoral®, in vivo. CONCLUSION: Our results show that PEO-b-PCL micelles can serve as stable and good solubilizing carriers for oral delivery of CyA providing similar pharmacokinetic profile to that of Neoral®.

Coassembly of Poly(ethylene oxide)-block-poly(methacrylic acid) and N-Dodecylpyridinium Chloride in Aqueous Solutions Leading to Ordered Micellar Assemblies within Copolymer Aggregates

2012 ◽  
Vol 45 (16) ◽  
pp. 6471-6480 ◽  
Author(s):  
Mariusz Uchman ◽  
Miroslav Štěpánek ◽  
Sylvain Prévost ◽  
Borislav Angelov ◽  
Jan Bednár ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Aqueous Solutions ◽  
Methacrylic Acid ◽  
Dodecylpyridinium Chloride ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene
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