Structure and Rheology of Mixed Polymeric Micelles Formed by Hydrophobically End-Capped Poly(ethylene oxide)

2008 ◽  
Vol 41 (17) ◽  
pp. 6523-6530 ◽  
Author(s):  
Frédéric Renou ◽  
Lazhar Benyahia ◽  
Taco Nicolai ◽  
Otto Glatter
Keyword(s):  
Ethylene Oxide ◽  
Polymeric Micelles ◽  
Poly Ethylene Oxide ◽  
Mixed Polymeric Micelles ◽  
Poly Ethylene

Structure and thermodynamics of mixed polymeric micelles with crystalline cores: tuning properties via co-assembly

Soft Matter ◽  
2019 ◽  
Vol 15 (39) ◽  
pp. 7777-7786 ◽  
Author(s):  
Nico König ◽  
Lutz Willner ◽  
Reidar Lund
Keyword(s):  
Aqueous Solution ◽  
Block Copolymers ◽  
Ethylene Oxide ◽  
Polymeric Micelles ◽  
Poly Ethylene Oxide ◽  
Mixed Polymeric Micelles ◽  
Poly Ethylene

We investigate micelles formed by mixtures of n-alkyl-poly(ethylene oxide) block copolymers, Cn-PEO, with different alkyl block lengths in aqueous solution.

scholarly journals Pharmacokinetics of Orally Administered Poly(Ethylene Oxide)-block-Poly(ε-Caprolactone) Micelles of Cyclosporine A in Rats: Comparison with Neoral®

2018 ◽  
Vol 21 (1s) ◽  
pp. 177s-191s ◽  
Author(s):  
Ziyad Binkhathlan ◽  
Raisuddin Ali ◽  
Wajhul Qamar ◽  
Afsaneh Lavasanifar
Keyword(s):  
Ethylene Oxide ◽  
Oral Administration ◽  
Cyclosporine A ◽  
Oral Delivery ◽  
Polymeric Micelles ◽  
Simulated Gastric Fluid ◽  
Pharmacokinetic Parameters ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Time Point

PURPOSE: The aim of this study was to assess the pharmacokinetics of methoxy poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) micellar formulation of cyclosporine A (CyA) following oral administration in rats making comparisons with its commercial microemulsion formulation, Neoral®. METHODS: PEO-b-PCL copolymer was synthesized and used to form micelles encapsulating CyA. The release of CyA from Neoral® and PEO-b-PCL as well as PEO-b-PCL degradation were assessed in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Polymeric micellar CyA and Neoral® were administered by oral gavage to healthy Wistar rats. At predetermined intervals, rats (n=5 for each time point) were euthanized, samples of blood and plasma were collected and analyzed for CyA using an LC-MS/MS assay. Blood and plasma pharmacokinetic parameters of CyA in its polymeric micellar formulation were compared to those of Neoral®. RESULTS: Polymeric micelles of CyA showed < 15 and 10% increase in diameter in SGF and SIF, respectively, within 24 h. PEO-b-PCL showed signs of minimal degradation when incubated for > 8 h in SGF, but was stable in SIF. Drug release in both SGF and SIF was comparable between the two formulations except for significantly higher release of CyA in SIF only at 24 h time point from Neoral®. Following oral administration (10 mg/kg), the blood AUC0-∞ and tmax of CyA in the polymeric micellar formulation was comparable to that for Neoral®. However, the Cmax of CyA-loaded PEO-b-PCL micelles was significantly (p < 0.05) higher than that obtained with Neoral® (2.10 ± 0.41 versus 1.40 ± 0.25 µg/mL, respectively). CyA had higher blood-to-plasma concentration ratios in polymeric micelles compared to Neoral®, in vivo. CONCLUSION: Our results show that PEO-b-PCL micelles can serve as stable and good solubilizing carriers for oral delivery of CyA providing similar pharmacokinetic profile to that of Neoral®.

Lenghty reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) polymeric micelles and gels for sustained release of antifungal drugs

2016 ◽  
Vol 510 (1) ◽  
pp. 17-29 ◽  
Author(s):  
Edgar. B. Figueroa-Ochoa ◽  
Eva M. Villar-Alvarez ◽  
Adriana Cambón ◽  
Dharmista Mistry ◽  
José Llovo ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Sustained Release ◽  
Polymeric Micelles ◽  
Antifungal Drugs ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Photoluminescent polymeric micelles from poly(ethylene oxide)-block-poly(((4-vinylphenyl)ethene-1,1,2-triyl)tribenzene) diblock copolymers

2018 ◽  
Vol 42 (9) ◽  
pp. 7283-7292 ◽  
Author(s):  
Muhammad Adeel ◽  
Sen Xu ◽  
Bingjie Zhao ◽  
Lei Li ◽  
Sixun Zheng
Keyword(s):  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Aqueous Media ◽  
Self Assembling ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

We report the synthesis of poly(ethylene oxide)-block-poly(((4-vinylphenyl)ethene-1,1,2-triyl)tribenzene) diblock copolymers via RAFT polymerization. The diblock copolymers were capable of self-assembling into photoluminescent micelles in aqueous media.

scholarly journals Preparation of Polymeric Micelles of Poly(Ethylene Oxide-b-Lactic Acid) and their Encapsulation With Lavender Oil

2016 ◽  
Vol 19 (6) ◽  
pp. 1356-1365 ◽  
Author(s):  
Tatiane M. Popiolski ◽  
Issei Otsuka ◽  
Sami Halila ◽  
Edvani C. Muniz ◽  
Valdir Soldi ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Oxide ◽  
Polymeric Micelles ◽  
Lavender Oil ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene
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