scholarly journals Congenital Urethral Diverticulum in Male Subject: Report of Three Cases

2018 ◽  
Vol 08 (02) ◽  
pp. 43-48
Author(s):  
Yaya Sow ◽  
Babacar Sine ◽  
Ibrahima Dara Diamé ◽  
Ndéye Aissatou Bagayogo ◽  
Amath Thiam ◽  
...  
2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S60-S61
Author(s):  
M Torrez ◽  
R Allen ◽  
J Zhou

Abstract Introduction/Objective Female urethra adenocarcinoma (FUA) in women is extremely rare, representing 0.02% of all women’s cancers and <1% of cancers in the female genitourinary tract. Intestinal-type primary adenocarcinoma of the urethra is even rarer, with only one documented case to our knowledge. Furthermore, PAX-8 immunoexpression in this entity has not been reported. Here we report an intestinal-type primary urethral adenocarcinoma that developed from inflammation-related metaplasia in urethral diverticulum with positive PAX-8 staining. Methods Clinical chart review and microscopic examination on the lung, urethral, and vaginal wall biopsies and immunohistochemistry were performed. Results A 64-year-old female with a 32-pack-year history of tobacco use was found to have multiple pulmonary nodules on imaging. The tumor cells were positive for CK7, CK20, SAT-B2, and PAX-8 and negative for TTF- 1/Napsin and ER. Positive PAX-8 immunoexpression raised the possibility of a gynecologic/Mullerian primary. Subsequent colonoscopy and imaging showed no evidence of colorectal or uterine tumors. The patient began having hematuria with intermittent urinary retention, and cystoscopy showed a 4 x 3 cm mass involving bladder neck circumferentially and invading into the vaginal wall. Urethral and vaginal tumor biopsies were performed. Morphologic examination of the urethral biopsy demonstrated intestinal metaplasia of squamous mucosa with transition from a mature to dysplastic phenotype where the adenocarcinoma originated from. The vaginal wall biopsy showed the same morphology. The urethral and vaginal wall biopsies showed a similar immunophenotype as the pulmonary nodule biopsy. Conclusion FUA is a rare, aggressive tumor that occurs in Skene’s glands. In our current case, however, it appeared to arise from inflammation-related metaplasia in urethral diverticulum. Another important finding of the case is the positive PAX-8 expression. Therefore in PAX-8 positive tumors, primary adenocarcinoma of lower urinary tract should be in the differential, along with gynecologic/Mullerian tumors.


Urology ◽  
2006 ◽  
Vol 67 (5) ◽  
pp. 1084.e19-1084.e21 ◽  
Author(s):  
Blanca M. Brandes ◽  
Hrair-George O. Mesrobian

Urology ◽  
1999 ◽  
Vol 53 (4) ◽  
pp. 818-819 ◽  
Author(s):  
Daniel S Blander ◽  
Gregory A Broderick ◽  
Eric S Rovner

2000 ◽  
Vol 164 (2) ◽  
pp. 428-433 ◽  
Author(s):  
LAURI J. ROMANZI ◽  
ASNAT GROUTZ ◽  
JERRY G. BLAIVAS

Urology ◽  
1974 ◽  
Vol 3 (1) ◽  
pp. 1-7 ◽  
Author(s):  
John Benjamin ◽  
Lee Elliott ◽  
J. Fenimore Cooper ◽  
Lyall Bjornson

2011 ◽  
Vol 54 (1) ◽  
pp. 48-52 ◽  
Author(s):  
A. Stephan-Carlier ◽  
J. Facione ◽  
A. Gervaise ◽  
J.-J. Chapus ◽  
D. Lagauche

2014 ◽  
Vol 31 (4) ◽  
pp. 275-282 ◽  
Author(s):  
Myung-Sook Ko ◽  
Jung-Ah Lee ◽  
Sun-Young Kang ◽  
Hye-Seon Jeon

2020 ◽  
Author(s):  
Lindsey Cox ◽  
Eric S. Rovner

Urogenital fistulas are a group of conditions in which the urinary tract is apparently connected to another organ system. Causes of fistula range from congenital anomalies, malignancy, trauma, infection or inflammatory conditions, ischemia, parturition, and iatrogenic sources – including surgery and radiation. Signs and symptoms of urinary tract fistula are variable and depend on the organ system involved and the size of the fistula. For patients who are appropriate surgical candidates, elective surgical repair is the mainstay of treatment of urinary tract fistula. Surgical techniques can be complex, but rely on the same key concepts: adequate exposure of the fistula tract; careful dissection and separation of the tissue layers, while minimizing cautery; multi-layer closure; watertight closure of each layer; meticulous hemostasis to prevent hematoma formation, but preserve vascular supply of tissues; use of well-vascularized tissue flaps; tension-free, non-overlapping suture lines; biopsy of tissues concerning for malignancy. This review contains 6 figures, 5 tables, and 82 references. Keywords: urogenital fistula, female bladder, vesical fistula, urinary bladder fistula, vesicovaginal fistula, urethrovaginal fistula, vaginal fistula, urethral diverticulum, urethral diverticulectomy, female urethra


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