scholarly journals Disease Prevention and Alleviation by Human Myoblast Transplantation

2016 ◽  
Vol 05 (02) ◽  
pp. 25-43 ◽  
Author(s):  
Peter K. Law
Keyword(s):  
Disease Prevention ◽  
Myoblast Transplantation ◽  
Human Myoblast

A New Immunodeficient Mouse Model for Human Myoblast Transplantation

2001 ◽  
Vol 12 (7) ◽  
pp. 823-831 ◽  
Author(s):  
R.N. Cooper ◽  
A. Irintchev ◽  
J.P. Di Santo ◽  
M. Zweyer ◽  
J.E. Morgan ◽  
...  
Keyword(s):  
Mouse Model ◽  
Immunodeficient Mouse ◽  
Myoblast Transplantation ◽  
Human Myoblast

Utilization of an Antibody Specific for Human Dystrophin to Follow Myoblast Transplantation in Nude Mice

1993 ◽  
Vol 2 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Johnny Huard ◽  
Geneviève Tremblay ◽  
Steve Verreault ◽  
Claude Labrecque ◽  
Jacques P. Tremblay
Keyword(s):  
Monoclonal Antibody ◽  
Nude Mice ◽  
Muscle Fibers ◽  
Dystrophin Gene ◽  
Mdx Mice ◽  
Myoblast Transplantation ◽  
Small Clusters ◽  
Human Dystrophin ◽  
Human Myoblast

Human myoblasts were transplanted in nude mice. The efficacy of these transplantations was analyzed using a monoclonal antibody (NCLDys3) specific for human dystrophin. This antibody did not reveal any dystrophin in nude mice that did not receive a human myoblast transplantation. However, about 30 days after a human myoblast transplantation, dystrophin-positive muscle fibers were observed. They were not abundant, and were present either in small clusters or isolated. This technique follows the fate of myoblast transplantation in animals that already have dystrophin, and distinguishes between new dystrophin-positive fibers due to the transplantation and the revertant fibers in mdx mice. Moreover, this technique does not require any labelling of the myoblasts before transplantation. It can also be used to detect dystrophin produced following the fusion of myoblasts transfected with the human dystrophin gene.

Human myoblast transplantation in immunodeficient and immunosuppressed mice: Evidence of rejection

1994 ◽  
Vol 17 (2) ◽  
pp. 224-234 ◽  
Author(s):  
Johnny Huard ◽  
Raynald Roy ◽  
Benoît Guérette ◽  
Steeve Verreault ◽  
Genevieve Trèmblay ◽  
...  
Keyword(s):  
Myoblast Transplantation ◽  
Human Myoblast ◽  
Immunosuppressed Mice

Extended Amplification In Vitro and Replicative Senescence: Key Factors Implicated in the Success of Human Myoblast Transplantation

2003 ◽  
Vol 14 (12) ◽  
pp. 1169-1179 ◽  
Author(s):  
R.N. Cooper ◽  
D. Thiesson ◽  
D. Furling ◽  
J.P. Di Santo ◽  
G.S. Butler-Browne ◽  
...  
Keyword(s):  
Replicative Senescence ◽  
Key Factors ◽  
Myoblast Transplantation ◽  
Human Myoblast

scholarly journals Targeted Gene Addition of Microdystrophin in Mice Skeletal Muscle via Human Myoblast Transplantation

2013 ◽  
Vol 2 ◽  
pp. e68 ◽  
Author(s):  
Basma F Benabdallah ◽  
Arnaud Duval ◽  
Joel Rousseau ◽  
Pierre Chapdelaine ◽  
Michael C Holmes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myoblast Transplantation ◽  
Human Myoblast

Human myoblast transplantation: A simple assay for tumorigenicity

1991 ◽  
Vol 1 (5) ◽  
pp. 341-343 ◽  
Author(s):  
J.P. Tremblay ◽  
B. Roy ◽  
M. Goulet
Keyword(s):  
Myoblast Transplantation ◽  
Human Myoblast

Human myoblast transplantation: Preliminary results of 4 cases

1992 ◽  
Vol 15 (5) ◽  
pp. 550-560 ◽  
Author(s):  
J. Huard ◽  
J. P. Bouchard ◽  
R. Roy ◽  
F. Malouin ◽  
G. Dansereau ◽  
...  
Keyword(s):  
Preliminary Results ◽  
Myoblast Transplantation ◽  
Human Myoblast
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