scholarly journals Non-Obese Type 2 Diabetic Rat Models-GK Rat and SDT Rat

2018 ◽  
Vol 08 (04) ◽  
pp. 396-420
Author(s):  
Takeshi Ohta ◽  
Tomohiko Sasase ◽  
Takayuki Gotoh ◽  
Masami Shinohara ◽  
Phanthila Sirichaiyakul ◽  
...  
Keyword(s):  
Diabetic Rat ◽  
Gk Rat ◽  
Rat Models ◽  
Type 2 Diabetic

scholarly journals Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
L. Al Kury ◽  
M. Smail ◽  
M. A. Qureshi ◽  
V. Sydorenko ◽  
A. Shmygol ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Model ◽  
Blood Lipid ◽  
Ventricular Myocardium ◽  
Diabetic Rat ◽  
Contractile Dysfunction ◽  
Gk Rat ◽  
Blood Lipid Profile ◽  
Type 2 Diabetic

The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients’ age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

scholarly journals Diabetic Complications in Obese Type 2 Diabetic Rat Models

2014 ◽  
Vol 63 (2) ◽  
pp. 121-132 ◽  
Author(s):  
Yoshiaki Katsuda ◽  
Takeshi Ohta ◽  
Katsuhiro Miyajima ◽  
Yusuke Kemmochi ◽  
Tomohiko Sasase ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Diabetic Rat ◽  
Rat Models ◽  
Type 2 Diabetic

The Effect of Rosiglitazone on Gluose Metabolism and Insulin Sensitivity in Non Obese Type 2 Diabetic Rat Models

2007 ◽  
Vol 31 (4) ◽  
pp. 319
Author(s):  
Mi Jin Kim ◽  
Eui Jong Chung ◽  
Byung Wook Ha ◽  
Ji Hoon Kim ◽  
Su Min Nam ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Diabetic Rat ◽  
Rat Models ◽  
Type 2 Diabetic

scholarly journals Diastolic function of the right ventricle is impaired in experimental type 2 diabetic rat models

2014 ◽  
Vol 44 ◽  
pp. 448-453 ◽  
Author(s):  
Ya MIAO ◽  
Wei ZHANG ◽  
Yuan ZHONG ◽  
Ming ZHONG ◽  
Xiao MA
Keyword(s):  
Right Ventricle ◽  
Diastolic Function ◽  
Diabetic Rat ◽  
Rat Models ◽  
Experimental Type ◽  
The Right ◽  
Type 2 Diabetic
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