scholarly journals Receptor binding specificity and origin of 2009 H1N1 pandemic influenza virus

2011 ◽  
Vol 03 (03) ◽  
pp. 234-248 ◽  
Author(s):  
Wei Hu
Keyword(s):  
Influenza Virus ◽  
Receptor Binding ◽  
Pandemic Influenza ◽  
Binding Specificity ◽  
H1n1 Pandemic ◽  
2009 H1n1 ◽  
Receptor Binding Specificity

scholarly journals Neuraminidase Inhibitor Sensitivity and Receptor-Binding Specificity of Cambodian Clade 1 Highly Pathogenic H5N1 Influenza Virus

2011 ◽  
Vol 55 (5) ◽  
pp. 2004-2010 ◽  
Author(s):  
M. Naughtin ◽  
J. C. Dyason ◽  
S. Mardy ◽  
S. Sorn ◽  
M. von Itzstein ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Receptor Binding ◽  
Reverse Genetics ◽  
Binding Specificity ◽  
Neuraminidase Inhibitor ◽  
H5n1 Influenza Virus ◽  
Highly Pathogenic ◽  
H5n1 Influenza ◽  
Receptor Binding Specificity ◽  
Pathogenic H5n1

ABSTRACTThe evolution of the highly pathogenic H5N1 influenza virus produces genetic variations that can lead to changes in antiviral susceptibility and in receptor-binding specificity. In countries where the highly pathogenic H5N1 virus is endemic or causes regular epidemics, the surveillance of these changes is important for assessing the pandemic risk. In Cambodia between 2004 and 2010, there have been 26 outbreaks of highly pathogenic H5N1 influenza virus in poultry and 10 reported human cases, 8 of which were fatal. We have observed naturally occurring mutations in hemagglutinin (HA) and neuraminidase (NA) of Cambodian H5N1 viruses that were predicted to alter sensitivity to neuraminidase inhibitors (NAIs) and/or receptor-binding specificity. We tested H5N1 viruses isolated from poultry and humans between 2004 and 2010 for sensitivity to the NAIs oseltamivir (Tamiflu) and zanamivir (Relenza). All viruses were sensitive to both inhibitors; however, we identified a virus with a mildly decreased sensitivity to zanamivir and have predicted that a V149A mutation is responsible. We also identified a virus with a hemagglutinin A134V mutation, present in a subpopulation amplified directly from a human sample. Using reverse genetics, we verified that this mutation is adaptative for human α2,6-linked sialidase receptors. The importance of an ongoing surveillance of H5N1 antigenic variance and genetic drift that may alter receptor binding and sensitivities of H5N1 viruses to NAIs cannot be underestimated while avian influenza remains a pandemic threat.

scholarly journals Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain

2013 ◽  
Vol 10 (1) ◽  
pp. 47 ◽  
Author(s):  
Masatoshi Okamatsu ◽  
Yoshihiro Sakoda ◽  
Takahiro Hiono ◽  
Naoki Yamamoto ◽  
Hiroshi Kida
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Influenza Virus Strain ◽  
2009 H1n1

scholarly journals Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9161 ◽  
Author(s):  
Fu-Shi Quan ◽  
Aswani Vunnava ◽  
Richard W. Compans ◽  
Sang-Moo Kang
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Virus Like Particle ◽  
2009 H1n1

scholarly journals Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray

2009 ◽  
Vol 27 (9) ◽  
pp. 797-799 ◽  
Author(s):  
Robert A Childs ◽  
Angelina S Palma ◽  
Steve Wharton ◽  
Tatyana Matrosovich ◽  
Yan Liu ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Binding Specificity ◽  
Influenza A H1n1 ◽  
Receptor Binding Specificity

scholarly journals Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

2013 ◽  
Vol 110 (12) ◽  
pp. 4592-4597 ◽  
Author(s):  
A. K. Harris ◽  
J. R. Meyerson ◽  
Y. Matsuoka ◽  
O. Kuybeda ◽  
A. Moran ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Neutralizing Antibodies ◽  
H1n1 Pandemic ◽  
2009 H1n1

scholarly journals PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

2011 ◽  
Vol 85 (14) ◽  
pp. 7020-7028 ◽  
Author(s):  
K. A. Bussey ◽  
E. A. Desmet ◽  
J. L. Mattiacio ◽  
A. Hamilton ◽  
B. Bradel-Tretheway ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Pandemic Influenza ◽  
Mammalian Cells ◽  
Polymerase Activity ◽  
H1n1 Pandemic ◽  
2009 H1n1
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