scholarly journals The unique features of SARS‐CoV‐2 transmission: Comparison with SARS‐CoV, MERS‐CoV and 2009 H1N1 pandemic influenza virus

2020 ◽  
Author(s):  
Zhonglan Wu ◽  
David Harrich ◽  
Zhongyang Li ◽  
Dongsheng Hu ◽  
Dongsheng Li
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
2009 H1n1

scholarly journals Potency of a vaccine prepared from A/swine/Hokkaido/2/1981 (H1N1) against A/Narita/1/2009 (H1N1) pandemic influenza virus strain

2013 ◽  
Vol 10 (1) ◽  
pp. 47 ◽  
Author(s):  
Masatoshi Okamatsu ◽  
Yoshihiro Sakoda ◽  
Takahiro Hiono ◽  
Naoki Yamamoto ◽  
Hiroshi Kida
Keyword(s):  
Influenza Virus ◽  
Virus Strain ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Influenza Virus Strain ◽  
2009 H1n1

scholarly journals Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9161 ◽  
Author(s):  
Fu-Shi Quan ◽  
Aswani Vunnava ◽  
Richard W. Compans ◽  
Sang-Moo Kang
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
H1n1 Pandemic ◽  
Virus Like Particle ◽  
2009 H1n1

scholarly journals Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

2013 ◽  
Vol 110 (12) ◽  
pp. 4592-4597 ◽  
Author(s):  
A. K. Harris ◽  
J. R. Meyerson ◽  
Y. Matsuoka ◽  
O. Kuybeda ◽  
A. Moran ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Neutralizing Antibodies ◽  
H1n1 Pandemic ◽  
2009 H1n1

scholarly journals PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

2011 ◽  
Vol 85 (14) ◽  
pp. 7020-7028 ◽  
Author(s):  
K. A. Bussey ◽  
E. A. Desmet ◽  
J. L. Mattiacio ◽  
A. Hamilton ◽  
B. Bradel-Tretheway ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Pandemic Influenza ◽  
Mammalian Cells ◽  
Polymerase Activity ◽  
H1n1 Pandemic ◽  
2009 H1n1

scholarly journals Molecular Structures of Native HA Trimers on 2009 H1N1 Pandemic Influenza Virus Complexed with Neutralizing Antibodies

2013 ◽  
Vol 104 (2) ◽  
pp. 414a ◽  
Author(s):  
Audray K. Harris ◽  
Joel R. Meyerson ◽  
Yumiko Matsuoka ◽  
Oleg Kuybeda ◽  
Amy Moran ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Neutralizing Antibodies ◽  
Molecular Structures ◽  
H1n1 Pandemic ◽  
2009 H1n1

CpG oligodeoxynucleotides protect against the 2009 H1N1 pandemic influenza virus infection in a murine model

2011 ◽  
Vol 89 (1) ◽  
pp. 124-126 ◽  
Author(s):  
Tao Jiang ◽  
Hui Zhao ◽  
Xiao-Feng Li ◽  
Yong-Qiang Deng ◽  
Juan Liu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Murine Model ◽  
Pandemic Influenza ◽  
Influenza Virus Infection ◽  
H1n1 Pandemic ◽  
Cpg Oligodeoxynucleotides ◽  
2009 H1n1

scholarly journals Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic

mBio ◽  
2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Alain Gagnon ◽  
Enrique Acosta ◽  
Stacey Hallman ◽  
Robert Bourbeau ◽  
Lisa Y. Dillon ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Pandemic Influenza ◽  
Excess Mortality ◽  
The United States ◽  
Influenza Viruses ◽  
Swine Flu ◽  
Modern World ◽  
H1n1 Pandemic ◽  
Risk Of Death ◽  
2009 H1n1

ABSTRACT Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 “swine flu” pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 “Spanish flu.” Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 “swine flu” pandemic and during the resurgent 2013–2014 H1N1 outbreak for those born at the time of the 1957 H2N2 “Asian flu” pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics. IMPORTANCE The relatively low mortality experienced by older individuals during the 2009 H1N1 influenza virus pandemic has been well documented. However, reported situations in which previous influenza virus exposures have enhanced susceptibility are rare and poorly understood. One such instance occurred in 1918—when those born during the heterosubtypic 1890 H3Nx influenza virus pandemic experienced the highest levels of excess mortality. Here, we demonstrate that this phenomenon was not unique to the 1918 H1N1 pandemic but that it also occurred during the contemporary 2009 H1N1 pandemic and 2013–2014 H1N1-dominated season for those born during the heterosubtypic 1957 H2N2 “Asian flu” pandemic. These data highlight the heretofore underappreciated phenomenon that, in certain instances, prior exposure to pandemic influenza virus strains can enhance susceptibility during subsequent pandemics. These results have important implications for pandemic risk assessment and should inform laboratory studies aimed at uncovering the mechanism responsible for this effect.

Sign in / Sign up

Export Citation Format

Share Document