scholarly journals Investigation of the Effects of Zebularine on Caspase-3 and Caspase-9 Involved in Anticancer and Apoptotic Mechanisms in SKBR3 Breast Cancer Cell Line

2019 ◽  
Vol 10 (03) ◽  
pp. 229-244
Author(s):  
Onur Eroglu ◽  
Merve Celen
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Caspase 3 ◽  
Cancer Cell Line ◽  
Caspase 9 ◽  
Skbr3 Breast Cancer Cell

scholarly journals Paclitaxel liposomes exert radio-sensitization effect on breast cancer cell line SK-BR-3 by regulating expressions of apoptotic proteins

2020 ◽  
Vol 19 (5) ◽  
pp. 1009-1013
Author(s):  
Guoling Yin ◽  
Xiaoping Li ◽  
Xiaofei Chang
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Caspase 3 ◽  
Cancer Cell Line ◽  
Combination Group ◽  
Apoptotic Proteins ◽  
Sensitization Effect

Purpose: To study the radio-sanitization effect of paclitaxel liposomes on breast cancer cells, SK-BR-3.Methods: Breast cancer cell line SK-BR-3 was cultured and made into a cell suspension. Four groups of cells were used: control and radiotherapy groups, paclitaxel group, and paclitaxel liposome + radiotherapy group (combination group). The growth inhibitory effects of the different treatments on SKBR-3 cells were determined with CCK-8 method. Apoptosis in each group was evaluated with flow cytometry, while Western blotting was employed to assay Bcl-2, Caspase-3 and Bax protein levels.Results: There were marked inhibitory effect on growth of SK-BR-3 cells in drug, radiotherapy and combination groups, relative to control, while apoptosis was greater in combination group than in drug and radiotherapy groups (p < 0.05). The Bcl-2 protein level was higher in radiotherapy, drug and combination groups than in control group, while Caspase-3 and Bax proteins were markedly higher thancontrol values (p < 0.05).Conclusion: Paclitaxel liposomes exert radio-sensitization effect on SK-BR-3 by regulating the levels of apoptotic proteins. This provides a basis for research and development of new drugs. Keywords: Paclitaxel liposomes, Apoptotic proteins, Breast cancer, SK-BR-3, Radiotherapy, Sensitization, Bcl-2, Caspase-3, Bax

scholarly journals Cytotoxicity Effect and Changes in the Expression of Caspase-9 Gene in Breast Cancer Cell Line (MCF-7) Treated with the Extract of Oscillatoria Cyanobacteria

2018 ◽  
Vol 12 (1) ◽  
pp. 26-34
Author(s):  
Ali Salehzadeh ◽  
Fatemeh Sayyad Delshadpour ◽  
Ataollah Sadat Shandiz ◽  
◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Caspase 9 ◽  
Mcf 7

Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line

Toxicon ◽  
2010 ◽  
Vol 56 (8) ◽  
pp. 1497-1505 ◽  
Author(s):  
Gina D’Suze ◽  
Arnaldo Rosales ◽  
Víctor Salazar ◽  
Carlos Sevcik
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Scorpion Venom ◽  
Skbr3 Breast Cancer Cell
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