scholarly journals Kinetics and mechanisms of glucose absorption in the rat small intestine under physiological conditions

2012 ◽  
Vol 03 (02) ◽  
pp. 191-200 ◽  
Author(s):  
Andrei A. Gruzdkov ◽  
Liudmila V. Gromova ◽  
Nadezhda M. Grefner ◽  
Yan Yu. Komissarchik
Keyword(s):  
Small Intestine ◽  
Glucose Absorption ◽  
Rat Small Intestine ◽  
Physiological Conditions

scholarly journals Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2474
Author(s):  
Lyudmila V. Gromova ◽  
Serguei O. Fetissov ◽  
Andrey A. Gruzdkov
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Metabolic Diseases ◽  
Glucose Absorption ◽  
Cellular Mechanisms ◽  
Physiological Conditions ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
New Strategy ◽  
Intestinal Glucose Absorption

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these diseases is hyperglycemia which can be associated with hyperphagia. Absorption of glucose in the small intestine physiologically contributes to the regulation of blood glucose levels, and hence, appears as a putative target for treatment of hyperglycemia. In fact, recent progress in understanding the molecular and cellular mechanisms of glucose absorption in the gut and its reabsorption in the kidney helped to develop a new strategy of diabetes treatment. Changes in blood glucose levels are also involved in regulation of appetite, suggesting that glucose absorption may be relevant to hyperphagia in metabolic diseases. In this review we discuss the mechanisms of glucose absorption in the small intestine in physiological conditions and their alterations in metabolic diseases as well as their relevance to the regulation of appetite. The key role of SGLT1 transporter in intestinal glucose absorption in both physiological conditions and in diabetes was clearly established. We conclude that although inhibition of small intestinal glucose absorption represents a valuable target for the treatment of hyperglycemia, it is not always suitable for the treatment of hyperphagia. In fact, independent regulation of glucose absorption and appetite requires a more complex approach for the treatment of metabolic diseases.

scholarly journals Effect of mazindol on glucose absorption in everted rat small intestine.

1986 ◽  
Vol 87 (6) ◽  
pp. 649-654
Author(s):  
Masahiko TSUCHIYA ◽  
Shuji INOUE ◽  
Masayuki SATTA ◽  
Hideki YOSHIMURA ◽  
Masataka ARITA ◽  
...  
Keyword(s):  
Small Intestine ◽  
Glucose Absorption ◽  
Rat Small Intestine

scholarly journals Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2

2007 ◽  
Vol 582 (1) ◽  
pp. 379-392 ◽  
Author(s):  
Oliver J. Mace ◽  
Julie Affleck ◽  
Nick Patel ◽  
George L. Kellett
Keyword(s):  
Small Intestine ◽  
Sweet Taste ◽  
Glucose Absorption ◽  
Taste Receptors ◽  
Rat Small Intestine ◽  
Sweet Taste Receptors

Hydrolyzed guar gum decreases postprandial blood glucose and glucose absorption in the rat small intestine

2009 ◽  
Vol 29 (6) ◽  
pp. 419-425 ◽  
Author(s):  
Toru Takahashi ◽  
Takeo Yokawa ◽  
Noriyuki Ishihara ◽  
Tsutomu Okubo ◽  
Djong-Chi Chu ◽  
...  
Keyword(s):  
Small Intestine ◽  
Blood Glucose ◽  
Guar Gum ◽  
Glucose Absorption ◽  
Postprandial Blood Glucose ◽  
Rat Small Intestine

scholarly journals Glucose absorption from surviving rat small intestine

1949 ◽  
Vol 110 (3-4) ◽  
pp. 281-293 ◽  
Author(s):  
R. B. Fisher ◽  
D. S. Parsons
Keyword(s):  
Small Intestine ◽  
Glucose Absorption ◽  
Rat Small Intestine

Changes in Absorptive and Peptide Hydrolase Activities in Rat Small Intestine after Administration of 5-Fluorouracil

1978 ◽  
Vol 54 (4) ◽  
pp. 411-418 ◽  
Author(s):  
M. L. G. Gardner ◽  
R. R. Samson ◽  
R. C. Heading
Keyword(s):  
Small Intestine ◽  
Water Absorption ◽  
Unit Length ◽  
Dry Weight ◽  
Glucose Absorption ◽  
Proximal Jejunum ◽  
Rat Small Intestine ◽  
Single Intraperitoneal Injection ◽  
Gastrointestinal Side Effects ◽  
Positive Correlations

1. Glucose absorption, water absorption and dipeptide hydrolase activities have been determined in isolated rat small intestine at 1, 3, 5 and 21 days after a single intraperitoneal injection of 5-fluorouracil. 2. Absorption rates and enzyme activities were elevated 1 day after treatment, but were reduced to 40% of control values at 3 and 5 days. Changes were seen regardless of whether absorption was expressed per unit length or per unit dry weight of intestine. 3. There were highly significant positive correlations between glucose or water absorption rates and peptidase activities, especially in proximal jejunum. The most significant correlation was observed between water absorption rate and jejunal l-Leu-Gly hydrolase activity. 4. Malabsorption may account for some of the gastrointestinal side effects associated with treatment with 5-fluorouracil. Enzyme measurements may be useful as an index of intestinal function.

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