scholarly journals Individual Differences in Blood Alcohol Concentrations after Moderate Drinking Are Mainly Regulated by Gastric Emptying Rate Together with Ethanol Distribution Volume

2012 ◽  
Vol 03 (06) ◽  
pp. 732-737 ◽  
Author(s):  
Shunji Oshima ◽  
Takeshi Haseba ◽  
Chiaki Masuda ◽  
Ema Kakimi ◽  
Manabu Sami ◽  
...  
Keyword(s):  
Individual Differences ◽  
Gastric Emptying ◽  
Distribution Volume ◽  
Blood Alcohol ◽  
Gastric Emptying Rate ◽  
Moderate Drinking ◽  
Ethanol Distribution

Some pearl millet-based foods promote satiety or reduce glycaemic response in a crossover trial

2020 ◽  
pp. 1-31
Author(s):  
Anna M.R. Hayes ◽  
Fanny Gozzi ◽  
Aminata Diatta ◽  
Tom Gorissen ◽  
Clay Swackhamer ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Pearl Millet ◽  
Octanoic Acid ◽  
Crossover Trial ◽  
Normal Weight ◽  
Glycaemic Response ◽  
Continuous Glucose Monitor ◽  
Gastric Emptying Rate ◽  
White Rice ◽  
Traditionally Prepared

Abstract In a previous trial in Mali, we showed traditional pearl millet couscous and thick porridge delayed gastric emptying (~5 h half-emptying times) in a normal weight population compared to non-traditional carbohydrate-based foods (pasta, potatoes, white rice; ~3 h half-emptying times), and in a gastric simulator we showed millet couscous had slower digestion than wheat couscous. In light of these findings, we tested the hypothesis in a normal weight U.S. population (n=14) that millet foods would reduce glycaemic response (continuous glucose monitor), improve appetitive sensations (Visual Analog Scale ratings), as well as reduce gastric emptying rate (13C octanoic acid breath test). Five carbohydrate-based foods (millet couscous – commercial and self-made, millet thick porridge, wheat couscous, white rice) were fed in a crossover trial matched on available carbohydrate basis. Significantly lower overall glycaemic response was observed for all millet-based foods and wheat couscous compared to white rice (p≤0.05). Millet couscous (self-made) had significantly higher glycaemic response than millet couscous (commercial) and wheat couscous (p<0.0001), but as there were no differences in peak glucose values (p>0.05) an extended glycaemic response was indicated for self-made couscous. Millet couscous (self-made) had significantly lower hunger ratings (p<0.05) and higher fullness ratings (p<0.01) than white rice, millet thick porridge, and millet couscous (commercial). A normal gastric emptying rate (<3 h half-emptying times) was observed for all foods, with no significant differences among them (p>0.05). In conclusion, some traditionally prepared pearl millet foods show the potential to reduce glycaemic response and promote satiety.

Role of gastric emptying rate in duodeno-gastro-esophageal reflux (DGER) in man

2000 ◽  
Vol 118 (4) ◽  
pp. A1258
Author(s):  
Gerardus H. Koek ◽  
Anthon Lerut ◽  
Daniel Sifrim ◽  
Jozef Janssens ◽  
Jan F. Tack
Keyword(s):  
Gastric Emptying ◽  
Esophageal Reflux ◽  
Gastric Emptying Rate

scholarly journals Electrogastrography in Delayed Gastric Emptying

2017 ◽  
Vol 38 (9-10) ◽  
pp. 181
Author(s):  
Badriul Hegar ◽  
Yvan Vandenplas
Keyword(s):  
Gastric Emptying ◽  
Gastric Motility ◽  
Delayed Gastric Emptying ◽  
Myoelectric Activity ◽  
Gastric Emptying Rate ◽  
Gastric Myoelectric Activity ◽  
Enteric Nerves ◽  
Gastric Muscle ◽  
Abnormal Rate ◽  
Smooth Muscle Contractions

Disorders of gastric motility are generally manifested by an abnormal rate of gastric emptying. The emptying process of the stomach is very complex, and knowledge is limited to the observation that gastric emptying rate is a highly variable phenomenon, and that delayed gastric emptying is frequently the case. The advances in the knowledge of the physiology of gastric muscle and enteric nerves, and the recognition of the patterns of organization of smooth muscle contractions gave a new input to the study of gastric motility. The gastric emptying can be monitored in various ways, such as manometry, scintigraphy, or electrogastrography (EGG). Recently, EGG has received more attention. There is correlation between the EGG signal obtained from body surface electrodes and signals obtained directly from electrodes locates in the gastric muscle (serosal records). Some studies showed an association between EGG-findings and gastric motility disorders, and indicate that EGG is a reliable, non-invasive, useful method to detect gastric myoelectric activity.

Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans

2002 ◽  
Vol 282 (2) ◽  
pp. R366-R371 ◽  
Author(s):  
K. E. Castiglione ◽  
N. W. Read ◽  
S. J. French
Keyword(s):  
Gastric Emptying ◽  
Dietary Intake ◽  
Test Meal ◽  
High Fat Diet ◽  
Lag Phase ◽  
High Fat ◽  
Free Living ◽  
Gastric Emptying Rate ◽  
High Carbohydrate ◽  
Before And After

Previous work has shown that the gastric emptying rate in animals and humans can adapt due to previous dietary intake. The present study investigated whether adaptation in gastric emptying rate due to consumption of a high-fat diet (HFD) is nutrient specific in humans. Gastric emptying of high-fat and high-carbohydrate test meals was measured (using gamma scintigraphy) before and after consumption of an HFD for 14 days in eight free-living male volunteers. Visual analog ratings of appetite were recorded throughout each test. There was no effect of HFD on any parameters of gastric emptying rate (lag phase, half-emptying time, and linear emptying rate) measured for carbohydrate test meals. HFD led to an acceleration of the linear emptying rate of the high-fat test meal (0.36 vs. 0.47%/min; P < 0.05). All meals reduced appetite ratings, but there were no differences between tests. These results support our previous findings of accelerated gastric emptying of high-fat test meals following an HFD and show that these changes appear to be nutrient specific, confirming recent studies in rats.

Preload of slowly digestible carbohydrate microspheres decreases gastric emptying rate of subsequent meal in humans

2017 ◽  
Vol 45 ◽  
pp. 46-51 ◽  
Author(s):  
Fatimata Cisse ◽  
Elizabeth A. Pletsch ◽  
Daniel P. Erickson ◽  
Mohammad Chegeni ◽  
Anna M.R. Hayes ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Gastric Emptying Rate

Activation of the gut calcium-sensing receptor by peptide agonists reduces rapid elevation of plasma glucose in response to oral glucose load in rats

2014 ◽  
Vol 306 (12) ◽  
pp. G1099-G1107 ◽  
Author(s):  
Maya Muramatsu ◽  
Tohru Hira ◽  
Arimi Mitsunaga ◽  
Eri Sato ◽  
Shingo Nakajima ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Glucose Tolerance ◽  
Oral Glucose ◽  
Calcium Sensing Receptor ◽  
Gastric Emptying Rate ◽  
Glucose Lowering ◽  
Conscious Rats ◽  
Lowering Effect ◽  
Calcium Sensing ◽  
Glucose Lowering Effect

The calcium-sensing receptor (CaSR) is expressed in various tissues, including the gastrointestinal tract. To investigate the role of gut CaSR on glycemic control, we examined whether single oral administration of CaSR agonist peptides affected the glycemic response in rats. Glucose tolerance tests were performed under oral or duodenal administration of various CaSR agonist peptides (γGlu-Cys, protamine, and poly-d-lysine hydrobromide) in conscious rats. Involvement of CaSR was determined by using a CaSR antagonist. Signaling pathways underlying CaSR agonist-modified glycemia were investigated using gut hormone receptor antagonists. The gastric emptying rate after the administration of CaSR agonist peptides was measured by the phenol red recovery method. Oral and duodenal administration of CaSR agonist peptides attenuated glycemic responses under the oral glucose tolerance test, but the administration of casein did not. The promotive effect on glucose tolerance was weakened by luminal pretreatment with a CaSR antagonist. Treatment with a 5-HT3 receptor antagonist partially diminished the glucose-lowering effect of peptides. Furthermore, the gastric emptying rate was decreased by duodenal administration of CaSR agonist peptides. These results demonstrate that activation of the gut CaSR by peptide agonists promotes glucose tolerance in conscious rats. 5-HT3 receptor and the delayed gastric emptying rate appear to be involved in the glucose-lowering effect of CaSR agonist peptides. Thus, activation of gut CaSR by dietary peptides reduces glycemic responses so that gut CaSR may be a potential target for the improvement of postprandial glycemia.

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