scholarly journals Possible Application of the Medicinal Plant Hyoscyamus albus in Phytoremediation: Excess Copper Compensates for Iron Deficiency, Depending on the Light Conditions

2014 ◽  
Vol 05 (26) ◽  
pp. 3812-3822 ◽  
Author(s):  
Noriko Tamari ◽  
Akemi Mine ◽  
Ari Sako ◽  
Seiya Tamagawa ◽  
Yasuhiro Tabira ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Medicinal Plant ◽  
Light Conditions ◽  
Excess Copper ◽  
Hyoscyamus Albus

scholarly journals Galactose oxidase/kelch repeat-containing protein is involved in the iron deficiency stress response in the roots of Hyoscyamus albus

Plant Root ◽  
2017 ◽  
Vol 11 (0) ◽  
pp. 58-63
Author(s):  
Yuki Kawahara ◽  
Takashi Hashimoto ◽  
Hideki Nakayama ◽  
Yoshie Kitamura
Keyword(s):  
Stress Response ◽  
Iron Deficiency ◽  
Galactose Oxidase ◽  
Hyoscyamus Albus

scholarly journals Root tip-dependent, active riboflavin secretion by Hyoscyamus albus hairy roots under iron deficiency

2008 ◽  
Vol 46 (4) ◽  
pp. 452-460 ◽  
Author(s):  
Ataru Higa ◽  
Erika Miyamoto ◽  
Laiq ur Rahman ◽  
Yoshie Kitamura
Keyword(s):  
Iron Deficiency ◽  
Hairy Roots ◽  
Root Tip ◽  
Hyoscyamus Albus

scholarly journals Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Anna Kowalczuk ◽  
Nabila Bourebaba ◽  
Katarzyna Kornicka-Garbowska ◽  
Eliza Turlej ◽  
Krzysztof Marycz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Medicinal Plant ◽  
Insulin Signaling ◽  
Hepg2 Cells ◽  
Low Grade ◽  
Jnk Pathway ◽  
Protein Levels ◽  
Organ Failures ◽  
Hyoscyamus Albus

Abstract Background Chronic superphysiological glucose and insulin concentrations are known to trigger several tissue and organ failures, including insulin resistance, oxidative stress and chronic low-grade inflammation. Hence, the screening for molecules that may counteract such conditions is essential in current existing therapeutic strategies, thereby the use of medicinal plant derivatives represents a promising axis in this regard. Methods In this study, the effect of a selected traditional medicinal plant, Hyoscyamus albus from which, calystegines have been isolated, was investigated in an experimental model of hyperinsulinemia and hyperglycemia induced on HepG2 cells. The mRNA and protein expression levels of different insulin signaling, gluconeogenic and inflammatory pathway- related molecules were examined. Additionally, cell viability and apoptosis, oxidative stress extent and mitochondrial dysfunctions were assayed using flow cytometric and qRT-PCR techniques. Results Treatment of IR HepG2 cells with calystegines strongly protected the injured cells from apoptosis, oxidative stress and mitochondrial integrity loss. Interestingly, nortropane alkaloids efficiently regulated the impaired glucose metabolism in IR HepG2 cells, through the stimulation of glucose uptake and the modulation of SIRT1/Foxo1/G6PC/mTOR pathway, which is governing the hepatic gluconeogenesis. Furthermore, the alkaloidal extract restored the defective insulin signaling pathway, mainly by promoting the expression of Insr at the mRNA and protein levels. What is more, treated cells exhibited significant mitigated inflammatory response, as evidenced by the modulation and the regulation of the NF- κB/JNK/TLR4 axis and the downstream proinflammatory cytokines recruitment. Conclusion Overall, the present investigation demonstrates that calystegines from Hyoscyamus albus provide cytoprotection to the HepG2 cells against insulin/glucose induced insulin resistance and apoptosis due to the regulation of SIRT1/Foxo1/G6PC/mTOR and NF-κB/JNK/TLR4 signaling pathways.

scholarly journals Techonolgy of Qualea grandiflora Mart. (Vochysiaceae) seeds

CERNE ◽  
2013 ◽  
Vol 19 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Sara Dousseau ◽  
Amauri Alves de Alvarenga ◽  
Lúcio de Oliveira Arantes ◽  
Izabel de Souza Chaves ◽  
Eduardo Valente Avelino
Keyword(s):  
Seed Germination ◽  
Medicinal Plant ◽  
Linear Increase ◽  
Seedling Development ◽  
Optimum Temperature ◽  
Light Conditions ◽  
Brazilian Savannah ◽  
Germination Process ◽  
Germination Speed ◽  
Different Temperatures

Qualea grandiflora Mart. (Vochysiaceae), commonly known as "pau-terra", is an arborous species native to the Brazilian savannah which possess commercial interests, as it can be used either as an ornamental or as a medicinal plant. "Pau-terra" can also be used in the heterogeneous reforestation of areas which are destined for restoration of permanent preservation degraded areas. Propagation studies with this species are scarce, being necessary then further clarification regarding the factors that influences the germination process. In this context, the objective of this work was to evaluate the influence of different temperatures, substrates and light conditions on seed germination. We selected light brown seeds which were subjected to different interactions between temperatures (15-25, 20-30, 25 and 30°C), substrate (paper, sand and vermiculite) and light (light and dark). All seeds were later dry-incubated at 32°C for 3, 6 and 12 hours. After treatments, seeds were kept in BOD at 58% RH and the following parameters were calculated: germination (%G) and germination speed index (GSI); the formation of normal and abnormal seedlings and the number dead seeds. Interaction was observed for all variables. In the optimum temperature range, the seeds behaved as photoblastic neutral or indifferent. Under alternating temperatures, darkness enhanced the germination, especially when combined with the lower temperatures. We noted that the sowing in sand, at 25°C, allowed the maintenance of suitable combinations of germination and seedling development. With respect to desiccation tolerance, "pau-terra" seeds presented an orthodox behavior, with a linear increase of the vigor as function of drying.

Is iron deficiency investigated appropriately?

2001 ◽  
Vol 120 (5) ◽  
pp. A728-A729
Author(s):  
A DIMAMBRO ◽  
T BROOKLYN ◽  
N HASLAM
Keyword(s):  
Iron Deficiency
Sign in / Sign up

Export Citation Format

Share Document