scholarly journals Effect of Methanol Extract of <i>Gomphrena celesioides</i> on Chloroquine-Induced Hepatotoxicity and Oxidative Stress in Male Wistar Rats

2019 ◽  
Vol 09 (04) ◽  
pp. 191-203
Author(s):  
Tijani S. Abiola ◽  
Awaje Dorcas ◽  
O. O. Babalola
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Male Wistar Rats ◽  
And Oxidative Stress

Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats- a preliminary study

2015 ◽  
Vol 31 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Wahab Imam Abdulmajeed ◽  
Habeeb Bolakale Sulieman ◽  
Maymunah Oloruntosin Zubayr ◽  
Aminu Imam ◽  
Abdulbasit Amin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Preliminary Study ◽  
And Oxidative Stress

scholarly journals The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
António Nogueira ◽  
Francisco Peixoto ◽  
Maria Manuel Oliveira ◽  
Carlos André Pires ◽  
Bruno Colaço ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Renal Mass ◽  
Wistar Rats ◽  
Reduced Glutathione ◽  
Mass Reduction ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
And Oxidative Stress

Purpose.This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction.Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment(n=14); RMR + CAA: RMR rats treated with CAA(n=13); SO: SO rats without treatment(n=13); and SO + CAA: SO rats treated with CAA(n=13). CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months.Results.RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity(p<0.05)and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity(p<0.05)and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function.Conclusions.These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.

scholarly journals Ameliorative potential of Aframomum melegueta extract in cadmium-induced hepatic damage and oxidative stress in male Wistar rats

2016 ◽  
pp. 094-099 ◽  
Author(s):  
Babatunji Oyinloye ◽  
Basiru Ajiboye ◽  
Oluwafemi Ojo ◽  
Habiba Musa ◽  
Sunday Onikanni ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Hepatic Damage ◽  
Male Wistar Rats ◽  
And Oxidative Stress

scholarly journals Effects of Aqueous Leaf Extract of Simarouba glauca DC (Simaroubaceae) on Lipoprotein Homeostasis and Oxidative Stress Biomarkers

2021 ◽  
Vol 1 (1) ◽  
pp. 20-29
Author(s):  
Sammydavies E. Osagie-Eweka ◽  
Noghayin J. Orhue ◽  
Eric I. Omogbai
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Biologically Active ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract ◽  
Simarouba Glauca ◽  
And Oxidative Stress

Background and Purpose: Simarouba glauca is widely reported to contain a number of biologically active compounds with potentials in the treatment of numerous diseases. The study was conducted to evaluate the sub-acute effects of the aqueous leaf extract of Simarouba glauca (AESG) on lipoproteins and oxidative stress biomarkers in male Wistar rats. Methods: Oral administration of AESG was carried out in line with the guidelines of the Organization for Economic Co-operation and Development (OECD), No. 425 using a total of 24 male Wistar rats allotted to four groups (n=6); given distilled water, 500, 1000, and 2000 mg/kg/day of AESG respectively for 30 days. Results: In plasma, there was a significant reduction (P?0.05) in HDL-cholesterol; elevated (P?0.05) triglycerides (TG) at 1000 and 2000 mg/kg/day; elevated (P?0.05), and LDL-cholesterol at 500 and 1000 mg/kg/day, relative to the control. While the level of liver total cholesterol (TC) reduced significantly, it increased in the heart. Catalase (CAT) activity in the liver increased significantly (P?0.05) at all doses. The dose of 1000 mg/kg/day significantly (P?0.05) elevated kidney CAT activity. The activities of superoxide dismutase (SOD) in liver and heart reduced (P?0.05) at 500 mg/kg/day. At all doses, the levels of reduced glutathione (GSH) in plasma, liver and heart were comparable with the control. Although, there were no significant changes in plasma and liver glutathione peroxidase (GSH-PX) activity at all doses, animals given 500 mg/kg had reduction (P?0.05) in the heart GSH-PX activity compared to the control. Conclusion: Oral sub-acute AESG at high doses altered lipid homeostasis in plasma and heart without lipid peroxidation or oxidative stress. The extract has the potential to cause hyperlipidemia.

Ameliorative Effect of Vitamin E on Cypermethrin Induced Hepatotoxicity and Oxidative Stress in Male Wistar Rats

2017 ◽  
Vol 7 (3) ◽  
pp. 445
Author(s):  
Renu Singh ◽  
A.K. Srivastava ◽  
Neeraj Kumar Gangwar ◽  
Uttam Singh ◽  
Raghavendra Singh
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Wistar Rats ◽  
Ameliorative Effect ◽  
Male Wistar Rats ◽  
And Oxidative Stress
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