scholarly journals Use of a naturally occurring codon bias for identifying topoisomerase mutations in ciprofloxacin resistant <i>Escherichia coli</i> using PCR and future prospects with other bacterial genera: A pilot study

2012 ◽  
Vol 02 (04) ◽  
pp. 366-371 ◽  
Author(s):  
Subramanian Krishnan ◽  
Dheepikaa Balasubramanian ◽  
B. Appala Raju ◽  
Baddireddi Subadhra Lakshmi
Keyword(s):  
Escherichia Coli ◽  
Pilot Study ◽  
Codon Bias ◽  
Future Prospects ◽  
Naturally Occurring

scholarly journals Podophyllotoxin: History, Recent Advances and Future Prospects

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 603
Author(s):  
Zinnia Shah ◽  
Umar Farooq Gohar ◽  
Iffat Jamshed ◽  
Aamir Mushtaq ◽  
Hamid Mukhtar ◽  
...  
Keyword(s):  
Structure Optimization ◽  
Cytokine Storm ◽  
Chemotherapeutic Drug ◽  
Future Prospects ◽  
Naturally Occurring ◽  
Pharmacologically Active ◽  
Almost All ◽  
Pharmacologically Active Compounds ◽  
Synthetic Derivatives ◽  
Related Compounds

Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior anticancer activity. It has recently been redeveloped for the purpose of treating cytokine storm in COVID-19 patients. Podophyllotoxin and its naturally occurring congeners have low bioavailability and almost all these initially discovered compounds cause systemic toxicity and development of drug resistance. Moreover, the production of synthetic derivatives that could suffice for the clinical limitations of these naturally occurring compounds is not economically feasible. These challenges demanded continuous devotions towards improving the druggability of these drugs and continue to seek structure-optimization strategies. The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This review focuses on the exigency of innovation and research required in the global R&D and pharmaceutical industry for podophyllotoxin and related compounds based on recent scientific findings and market predictions.

SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest)

1999 ◽  
Vol 445 (1) ◽  
pp. 81-91 ◽  
Author(s):  
Sebastian Kevekordes ◽  
Volker Mersch-Sundermann ◽  
Christian M Burghaus ◽  
Jan Spielberger ◽  
Heinz H Schmeiser ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Sos Induction ◽  
Naturally Occurring ◽  
Sos Chromotest

scholarly journals Sleep during naturally occurring respiratory infections: A pilot study

2019 ◽  
Vol 79 ◽  
pp. 236-243 ◽  
Author(s):  
Julie Lasselin ◽  
Michael Ingre ◽  
Christina Regenbogen ◽  
Mats J. Olsson ◽  
Maria Garke ◽  
...  
Keyword(s):  
Pilot Study ◽  
Respiratory Infections ◽  
Naturally Occurring

scholarly journals Insect-Mediated Dispersal of the Rhizobacterium Pseudomonas chlororaphis

1998 ◽  
Vol 88 (12) ◽  
pp. 1248-1254 ◽  
Author(s):  
William E. Snyder ◽  
David W. Tonkyn ◽  
Daniel A. Kluepfel
Keyword(s):  
Escherichia Coli ◽  
Adult Stage ◽  
Genetically Modified ◽  
Insect Pest ◽  
Corn Rootworm ◽  
Transmission Route ◽  
Pseudomonas Chlororaphis ◽  
Naturally Occurring ◽  
Southern Corn Rootworm ◽  
Corn Plants

The southern corn rootworm, Diabrotica undecimpunctata subsp. howardi, a common and mobile insect pest, was shown to transmit the rhizobacte-rium Pseudomonas chlororaphis strain L11 between corn plants. Strain L11 has been genetically modified to contain the lacZY genes from Escherichia coli. It can reach high densities on roots and invade the roots and move into the foliage. D. undecimpunctata subsp. howardi became infested with L11 as larvae while feeding on roots of seed-inoculated corn and retained the bacteria through pupation, molting to the adult stage, and emergence from the soil. Bacterial densities on or in the insects increased 100-fold after they fed again as adults on L11-infested foliage. Adults retained the bacteria for at least 2 weeks after last exposure and could transmit L11 to new plants. The likelihood of transmission decreased with time since last exposure to L11, but increased with time spent on the new plants. This research demonstrates that rhizobacteria can escape the rhizosphere by moving in or onto foliage, where they can then be acquired and transmitted by insects. This transmission route may be common among naturally occurring rhizobacteria and facilitate the dispersal of both beneficial and harmful soilborne microorganisms.

A pilot study of the effect of audible sound on the growth of Escherichia coli

2010 ◽  
Vol 78 (2) ◽  
pp. 367-371 ◽  
Author(s):  
Gu Shaobin ◽  
Ying Wu ◽  
Kewei Li ◽  
Shichang Li ◽  
Shengyun Ma ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pilot Study ◽  
Audible Sound

The Structural Gene for Microcin H47 Encodes a Peptide Precursor with Antibiotic Activity

1999 ◽  
Vol 43 (9) ◽  
pp. 2176-2182 ◽  
Author(s):  
Eliana Rodríguez ◽  
Carina Gaggero ◽  
Magela Laviña
Keyword(s):  
Escherichia Coli ◽  
Gene Fusion ◽  
Genetic System ◽  
Antibiotic Activity ◽  
Peptide Antibiotic ◽  
Bifunctional Protein ◽  
Naturally Occurring ◽  
Hydrophobic Peptide ◽  
Peptide Precursor ◽  
Highly Hydrophobic

ABSTRACT Microcin H47 is a bactericidal antibiotic produced by a naturally occurring Escherichia coli strain isolated in Uruguay. The microcin genetic system is located in the chromosome and extends over a 10-kb DNA segment containing the genes required for microcin synthesis, secretion, and immunity. The smallest microcin synthesis gene,mchB, was sequenced and shown to encode a highly hydrophobic peptide. An mchB-phoA gene fusion, which directed the synthesis of a hybrid bifunctional protein with both PhoA and microcin H47-like activities, was isolated. The results presented herein lead us to propose that microcin H47 is indeed a ribosomally synthesized peptide antibiotic and that its peptide precursor already has antibiotic activity of the same specificity as that of mature microcin.

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