scholarly journals Assessment of Linear Discrimination and Nonlinear Discrimination Analysis in Diagnosis Alzheimer’s Disease in Early Stages

2020 ◽  
Vol 09 (02) ◽  
pp. 21-32
Author(s):  
Roya Golestani ◽  
Akbar Gharbali ◽  
Surena Nazarbaghi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Discrimination Analysis ◽  
Early Stages ◽  
Linear Discrimination

p35 Deficiency Accelerates HMGB-1-mediated Neuronal Death in the Early Stages of an Alzheimer’s disease Mouse Model

2013 ◽  
Vol 10 (8) ◽  
pp. 829-843 ◽  
Author(s):  
Ahram Jang ◽  
Hyunjeong Liew ◽  
Yun-Mi Kim ◽  
Heesoon Choi ◽  
Saeromi Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Neuronal Death ◽  
Early Stages

scholarly journals IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease

Cell Reports ◽  
2021 ◽  
Vol 36 (9) ◽  
pp. 109574
Author(s):  
Helena C. Brigas ◽  
Miguel Ribeiro ◽  
Joana E. Coelho ◽  
Rui Gomes ◽  
Victoria Gomez-Murcia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Stages

scholarly journals Smell and taste recognition in early stages of late-onset Alzheimer’s disease

SURG Journal ◽  
2010 ◽  
Vol 4 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Nila Ilhamto ◽  
Lisa M Duizer
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Health Status ◽  
Healthy Aging ◽  
Late Onset ◽  
Word Recall ◽  
Early Stages ◽  
Predictive Variables ◽  
Healthy Elderly ◽  
Inadequate Nutrition

Problems of inadequate nutrition and energy intake are common in the aging population. Smell and taste deficits associated with Late-Onset Alzheimer’s Disease (LOAD) may accentuate the decline in nutritional status of elderly individuals and indirectly enhance progression of cognitive problems in LOAD. The objective of this study was to explore and characterize smell and taste recognition abilities in early stages of LOAD, beyond that of normal healthy aging. A total of 29 healthy-younger subjects aged 18-40 (HY), 13 healthy-elderly (HA) and six elderly adults diagnosed with LOAD (AD) aged 60-85, were recruited from the Guelph community. The Sniffin’ Sticks Screening Test (SSST) and Taste Strips were used to test olfactory and gustatory functions, respectively. Participants also completed the mini-mental state examination (MMSE), clock test and word recall tests to assess cognitive/memory skills. Compared to HA individuals, people with AD had significant odour recognition impairment. Correlation analysis also revealed an age-associated decline in overall taste ability. When specific tastes were examined, impairments in sour and bitter identification were observed with increasing age. However, no significant differences in specific taste abilities were found between HA and AD individuals. In predicting health status (ie. presence or absence of LOAD), an assessment of all variables in this study was conducted using Generalized Linear Model (GLM). Results showed that sweet recognition and clock test scores were the best predictive variables of health status. However, this is a preliminary model that needs refinement through further research using more individuals.

An Autonomous Intelligent System for the Private Outdoors Monitoring of People with Mild Cognitive Impairments

2015 ◽  
pp. 137-152 ◽  
Author(s):  
Antoni Martínez-Ballesté ◽  
Frederic Borràs Budesca ◽  
Agustí Solanas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Intelligent System ◽  
Cognitive Impairments ◽  
Everyday Activities ◽  
Early Stages

The aim of this chapter is to describe a system for the private outdoor monitoring of patients with Mild Cognitive Impairments (MCI) and dementia. The system has been designed for patients suffering from early stages of Alzheimer's disease and people suffering from MCI and dementia. Virtually, the system may be applied to any person capable of living autonomously but might get lost whilst doing his/her everyday activities, due to a decrease in their cognitive function. The system uses off-the-shelf smartphones carried by patients to detect abnormal situations and to raise alarms accordingly. The authors describe the system, detail its features, and discuss its utility and relevance both technically and socially.

scholarly journals Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease

2019 ◽  
Vol 40 (12) ◽  
pp. 3431-3451 ◽  
Author(s):  
Long Xie ◽  
Laura E. M. Wisse ◽  
John Pluta ◽  
Robin de Flores ◽  
Virgine Piskin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Automated Segmentation ◽  
Early Stages
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