Neurons Derived from Induced Pluripotent Stem Cells of Patients with Down Syndrome Reproduce Early Stages of Alzheimer’s Disease Type Pathology in vitro

2017 ◽  
Vol 56 (2) ◽  
pp. 835-847 ◽  
Author(s):  
Erdem B. Dashinimaev ◽  
Alexander S. Artyuhov ◽  
Alexey P. Bolshakov ◽  
Ekaterina A. Vorotelyak ◽  
Andrey V. Vasiliev
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Down Syndrome ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Type ◽  
Early Stages ◽  
Induced Pluripotent

scholarly journals Utilization of Human Induced Pluripotent Stem Cells-Derived In vitro Models for the Future Study of Sex Differences in Alzheimer’s Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Sopak Supakul ◽  
Hideyuki Okano ◽  
Sumihiro Maeda
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Clinical Trials ◽  
Induced Pluripotent Stem Cells ◽  
Sex Hormones ◽  
Pluripotent Stem Cells ◽  
Hormone Treatment ◽  
Induced Pluripotent

Alzheimer’s disease (AD) is an aging-dependent neurodegenerative disease that impairs cognitive function. Although the main pathologies of AD are the aggregation of amyloid-beta (Aβ) and phosphorylated Tau protein, the mechanisms that lead to these pathologies and their effects are believed to be heterogeneous among patients. Many epidemiological studies have suggested that sex is involved in disease prevalence and progression. The reduction of sex hormones contributes to the pathogenesis of AD, especially in females, suggesting that the supplementation of sex hormones could be a therapeutic intervention for AD. However, interventional studies have revealed that hormone therapy is beneficial under limited conditions in certain populations with specific administration methods. Thus, this suggests the importance of identifying crucial factors that determine hormonal effects in patients with AD. Based on these factors, it is necessary to decide which patients will receive the intervention before starting it. However, the long observational period and many uncontrollable environmental factors in clinical trials made it difficult to identify such factors, except for the APOE ε4 allele. Induced pluripotent stem cells (iPSCs) derived from patients can differentiate into neurons and recapitulate some aspects of AD pathogenesis. This in vitro model allows us to control non-cell autonomous factors, including the amount of Aβ aggregates and sex hormones. Hence, iPSCs provide opportunities to investigate sex-dependent pathogenesis and predict a suitable population for clinical trials of hormone treatment.

scholarly journals Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer’s Disease: The Human Brain Outside the Dish

2017 ◽  
Vol 11 (1) ◽  
pp. 27-38 ◽  
Author(s):  
Godwin Tong ◽  
Pablo Izquierdo ◽  
Rana Arham Raashid
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Human Brain ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Primary Cultures ◽  
The Elderly ◽  
Global Health Issue ◽  
Induced Pluripotent

Background:Neurodegenerative diseases like Alzheimer’s Disease (AD) are a global health issue primarily in the elderly. Although AD has been investigated using primary cultures, animal models and post-mortem human brain tissues, there are currently no effective treatments.Summary:With the advent of induced pluripotent stem cells (iPSCs) reprogrammed from fully differentiated adult cells such as skin fibroblasts, newer opportunities have arisen to study the pathophysiology of many diseases in more depth. It is envisioned that iPSCs could be used as a powerful tool for neurodegenerative disease modelling and eventually be an unlimited source for cell replacement therapy. This paper provides an overview of; the contribution of iPSCs towards modeling and understanding AD pathogenesis, the novel human/mouse chimeric models in elucidating current AD pathogenesis hypotheses, the possible use of iPSCs in drug screening, and perspectives on possible future directions.Key messages:Human/mouse chimeric models using iPSCs to study AD offer much promise in better replicating AD pathology and can be further exploited to elucidate disease pathogenesis with regards to the neuroinflammation hypothesis of AD.

scholarly journals Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease

2012 ◽  
Vol 120 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Lezanne Ooi ◽  
Kuldip Sidhu ◽  
Anne Poljak ◽  
Greg Sutherland ◽  
Michael D. O’Connor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Drug Discovery ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Modelling ◽  
Induced Pluripotent

scholarly journals Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Nature ◽  
2012 ◽  
Vol 482 (7384) ◽  
pp. 216-220 ◽  
Author(s):  
Mason A. Israel ◽  
Shauna H. Yuan ◽  
Cedric Bardy ◽  
Sol M. Reyna ◽  
Yangling Mu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease ◽  
Induced Pluripotent
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