scholarly journals Broncho-vaxom alleviates persistent allergic rhinitis in patients by improving Th1/Th2 cytokine balance of nasal mucosa

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Q. Meng ◽  
P. Li ◽  
Y. Li ◽  
J. Chen ◽  
L. Wang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Th2 Cytokine ◽  
Cytokine Balance ◽  
Persistent Allergic Rhinitis

scholarly journals Eosinophil Chemokines and Clara Cell Protein 16 Production in Nasal Mucosa of Patients with Persistent Allergic Rhinitis

2017 ◽  
Vol 49 (3) ◽  
pp. 178-182 ◽  
Author(s):  
Aleksandar Peric ◽  
Cveta Spadijer Mirkovic ◽  
Biserka Vukomanovic Durdevic ◽  
Aneta V. Peric ◽  
Danilo Vojvodic
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Clara Cell ◽  
Cell Protein ◽  
Clara Cell Protein ◽  
Persistent Allergic Rhinitis

A prospective study of bacterial flora in nasal cavity of patients with persistent allergic rhinitis

2012 ◽  
Vol 50 (2) ◽  
pp. 139-146
Author(s):  
M.B. Taylor ◽  
I.T. Tan ◽  
K.T. Chan ◽  
L. Shen ◽  
L. Shi ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Cavity ◽  
Nasal Mucosa ◽  
Bacterial Colonization ◽  
Bacterial Flora ◽  
Bacterial Load ◽  
House Dust Mites ◽  
Survey Study ◽  
Persistent Allergic Rhinitis ◽  
Significant Difference

It remains unanswered whether persistent allergic inflammation in nasal mucosa alters bacterial colonization and infection. The aim of this study was to investigate the bacterial flora in the nasal cavity of patients with persistent allergic rhinitis (PAR) and to correlate the bacteriological findings with presence of nasal symptoms, nasal eosinophil and neutrophil counts. A total of 255 subjects, aged between 6 - 74 years (mean 33.9 years) was randomly selected from a population-based rhinitis survey study in Singapore. All subjects went through a thorough medical history and nasal examinations. Serum specific IgE to a panel of common house dust mites, nasal cytological and microbiological examinations were performed. PAR was diagnosed in 107 patients and none of them had received previous regular therapy. There is a significant relationship between PAR and eosinophil grades, but not with neutrophil count. No statistically significant difference was found in quantitative and qualitative bacterial flora in nasal cavity between PAR patients and subjects with non-rhinitis or with non-allergic rhinitis. There is a significant inverse correlation between ongoing rhinorrhoea and quantitative bacterial load, and between signs of nasal mucosa (pale and edema) and the presence and type of bacterial pathogens. In conclusion, our study demonstrates that patients with untreated (or using PRN medicine) PAR do not result in a significant change in bacterial flora in their nasal cavity.

Increased Expression of YKL-40 in Mild and Moderate/Severe Persistent Allergic Rhinitis and its Possible Contribution to Remodeling of Nasal Mucosa

2013 ◽  
Vol 27 (5) ◽  
pp. 372-380 ◽  
Author(s):  
Se Jin Park ◽  
Young Joon Jun ◽  
Tae Hoon Kim ◽  
Jong Yoon Jung ◽  
Gyu Ho Hwang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Persistent Allergic Rhinitis

scholarly journals TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Lauriello ◽  
Alessandra Micera ◽  
Paola Muzi ◽  
Lino Di Rienzo Businco ◽  
Sergio Bonini
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Inferior Turbinate ◽  
Vasomotor Rhinitis ◽  
Tlr9 Expression ◽  
Persistent Allergic Rhinitis ◽  
Evolutionarily Conserved ◽  
Chronic Rhino Sinusitis ◽  
Nasal Inflammation ◽  
Severity Of The Disease

Background. Toll-like receptors (TLRs) represent a family of evolutionarily conserved proteins, that represent a fundamental link between innate and adaptive immune responses.Aim. The purpose of this study was to investigate the expression of TLR4 and TLR9 in the normal nasal mucosa and in the mucosa of subjects with different phenotypes of rhinitis.Methodology. A confocal analysis of TLR4 and TLR9 (co)expression was carried out on biopsies from the inferior turbinate obtained from 4 patients affected by persistent allergic rhinitis, 8 patients with chronic rhino-sinusitis, and 6 patients with vasomotor rhinitis The results were compared with those of specimens obtained from 4 subjects undergoing nasal surgery, but with signs of nasal inflammation.Results. TLR4 and TLR9 were expressed in the healthy nasal mucosa; TLR4 and TLR9 expression was significantly decreased in allergic rhinitis. TLR4 was over expressed in the epithelium of chronic rhino-sinusitis. Both TLRs were co-expressed in the sub-epithelial infiltrate of chronic and vasomotor rhinitis, even though this expression was higher in the former compared with the latter.Conclusions. This study indicates that TLR4 and TLR9 show a different pattern of expression in different phenotypes of rhinitis, possibly related to the type and severity of the disease.

scholarly journals Petroleum extract of Farfarae Flos alleviates nasal symptoms by regulating the Th1-Th2 cytokine balance in a mouse model of Allergic Rhinitis

2021 ◽  
Vol 18 (2) ◽  
pp. 555-563
Author(s):  
Yongyan Wu ◽  
Xiaojuan Zhao ◽  
Jiajia Cui ◽  
Yujia Guo ◽  
Xiwang Zheng ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mouse Model ◽  
Th2 Cytokine ◽  
Nasal Symptoms ◽  
Cytokine Balance

Nerve growth factor localization in the nasal mucosa of patients with persistent allergic rhinitis

Allergy ◽  
2009 ◽  
Vol 64 (1) ◽  
pp. 112-117 ◽  
Author(s):  
M. Bresciani ◽  
F. Lalibertè ◽  
M. F. Lalibertè ◽  
C. Gramiccioni ◽  
S. Bonini
Keyword(s):  
Allergic Rhinitis ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nasal Mucosa ◽  
Nerve Growth ◽  
Persistent Allergic Rhinitis

scholarly journals Nasal Administration of Lipopolysaccharide Exacerbates Allergic Rhinitis through Th2 Cytokine Production from Mast Cells

Allergies ◽  
2021 ◽  
Vol 1 (4) ◽  
pp. 216-224
Author(s):  
Noriaki Aoi ◽  
Takafumi Fuchiwaki ◽  
Ichiro Morikura ◽  
Hideyuki Kawauchi ◽  
Tatsunori Sakamoto
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Practice ◽  
Mast Cells ◽  
Nasal Mucosa ◽  
Cytokine Production ◽  
Nasal Administration ◽  
Eosinophil Infiltration ◽  
Dependent Manner ◽  
Th2 Cytokine ◽  
Nasal Symptoms

Background: Microbial infection or exposure to endotoxin later in life exacerbates established asthma. Mast cells are involved in the exacerbation of asthma. This exacerbation involves a toll-like receptor (TLR)–mediated response of mast cells. In the clinical practice of otolaryngology, otolaryngologists experience an exacerbation of nasal congestion when infectious rhinitis develops in patients with allergic rhinitis, but the mechanisms are unknown. Therefore, this study investigated the effect of lipopolysaccharide (LPS) on allergic rhinitis using a mouse allergic rhinitis model. Methods: Female BALB/c mice, TLR4 gene mutant C3H/HeJ mice or mast cell–deficient WBB6F1-W/Wv mice were sensitized intraperitoneally with ovalbumin (OVA)/alum, and were intranasal challenged with OVA and/or LPS. Nasal symptoms and histologic changes were examined. Cytokines in nasal tissue were examined by Western blot. The effects of LPS on degranulation and cytokine production of bone marrow–derived mast cells (BMMCs) were investigated. Results: Nasal administration of LPS together with the antigen exacerbated nasal symptoms, eosinophil infiltration of the nasal mucosa, and increased IL-5 production in the nasal mucosa. It was not observed in C3H/HeJ mice and WBB6F1-W/Wv mice. The addition of LPS increased the production of IL-5 from BMMCs in a dose-dependent manner, but no effect on degranulation was observed. Conclusions: Intranasal administration of LPS exacerbates allergic rhinitis through Th2 cytokine production from mast cells. This observation provides clues to the mechanism of exacerbation of allergic rhinitis caused by an infection in daily clinical practice.

Sign in / Sign up

Export Citation Format

Share Document