scholarly journals Exhaled and nasal nitric oxide in chronic rhinosinusitis patients with nasal polyps in primary care

2018 ◽  
Vol 56 (1) ◽  
pp. 59-64 ◽  
Author(s):  
M. Frendo ◽  
K. Hakansson ◽  
S. Schwer ◽  
A.T. Ravn ◽  
H. Meteran ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Primary Care ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Nasal Nitric Oxide

Predictive and Diagnostic Value of Nasal Nitric Oxide in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

2020 ◽  
Vol 181 (11) ◽  
pp. 853-861
Author(s):  
Hao Lv ◽  
Pei-Qiang Liu ◽  
Rong Xiang ◽  
Wei Zhang ◽  
Shi-Ming Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Upper Airway ◽  
Central China ◽  
Clinical Parameters ◽  
Total Ige ◽  
Nasal Nitric Oxide ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Plasma Cytokines

<b><i>Background:</i></b> A hallmark of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is mucosal eosinophil-predominant inflammation. Nasal nitric oxide (nNO) is a known biomarker of eosinophilic inflammation in the upper airway. However, the utility of nNO measurement in the upper airway remains controversial. The present study aimed to compare the use of other clinical parameters with nNO to prediagnose patients with eCRSwNP from Central China. <b><i>Methods:</i></b> From June 2019 to December 2019, 70 patients with CRSwNP undergoing endoscopic sinus surgery and 30 healthy subjects were enrolled. nNO measurements were performed in all of these subjects. Computed tomography scans, full blood count with differential analysis, and determination of total immunoglobulin E (total IgE) and plasma cytokines were performed before surgery. Receiver operating characteristic curves and logistic regression analysis were used to assess the predictive potential of the clinical parameters. <b><i>Results:</i></b> We recruited 24 patients with eCRSwNP and 46 with noneosinophilic CRSwNP (non-eCRSwNP). In patients with eCRSwNP, nNO levels were significantly higher than those in patients with non-eCRSwNP (<i>p</i> &#x3c; 0.0001). Blood eosinophil percentages and counts, total IgE, and CT-derived ethmoid sinus and maxillary sinus ratio (E/M ratio) were all significantly higher compared with those in patients with non-eCRSwNP (<i>p</i> &#x3c; 0.05). To diagnose eCRSwNP, the highest area under the curve (0.803) was determined for nNO. At a cutoff of &#x3e;329 parts per billion (ppb), the sensitivity was 83.30% and the specificity was 71.70%. However, the levels of plasma cytokines Th1/Th2 were not significantly different between the histological types of CRSwNP (<i>p</i> &#x3e; 0.05). <b><i>Conclusion:</i></b> Measurement of nNO is useful for the early diagnosis of eCRSwNP.

scholarly journals Nasal Nitric Oxide in Chronic Rhinosinusitis with or without Nasal Polyps: A Systematic Review with Meta-Analysis

2020 ◽  
Vol 9 (1) ◽  
pp. 200 ◽  
Author(s):  
Pasquale Ambrosino ◽  
Antonio Molino ◽  
Giorgio Alfredo Spedicato ◽  
Paolo Parrella ◽  
Roberto Formisano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Regression Models ◽  
Nasal Polyps ◽  
Meta Analysis ◽  
Final Analysis ◽  
Healthy Controls ◽  
Intranasal Corticosteroids ◽  
Nasal Nitric Oxide ◽  
And Control

Background and Aims: There has been a recent growing interest in the role of nasal nitric oxide (nNO) as a biomarker for osteomeatal complex obstruction in paranasal sinus diseases. By using meta-analysis, we systematically reviewed the literature to establish the possible link between nNO concentration and chronic rhinosinusitis with nasal polyps (CRSwNP) or without (CRSsNP). Methods: We systematically searched the EMBASE, PubMed, Scopus, and Web of Science databases for related studies. Differences between controls and cases were reported as standardized mean difference (SMD), with 95% confidence intervals (95% CI), using the random-effects method. Results: We selected 23 articles for the final analysis: 15 with data on 461 CRSwNP patients and 384 healthy controls, 10 with data on 183 CRSsNP patients and 260 controls, and 14 studies on 372 CRSwNP and 297 CRSsNP patients. CRSwNP patients showed significantly lower nNO values when compared to both healthy controls (SMD: −1.495; 95% CI: −2.135, −0.854; p < 0.0001) and CRSsNP patients (SMD: −1.448; 95% CI: −2.046, −0.850; p < 0.0001). Sensitivity and subgroup analyses confirmed the results, which were further refined by regression models. They showed that an increasing aspiration flow is related to a greater difference in nNO levels between cases and control subjects. We also documented lower nNO levels in CRSsNP patients with respect to controls (SMD: −0.696; 95% CI: −1.189, −0.202; p = 0.006), being this result no longer significant when excluding patients in therapy with intranasal corticosteroids. As shown by regression models, the increased Lund–Mackay score indicates a high effect size. Conclusions: nNO levels are significantly lower in CRSwNP, especially when using higher aspiration flows. Additional studies are needed to define one single standardized method and normal reference values for nNO.

scholarly journals Eosinophilic inflammation of the paranasal sinuses and reduced nasal nitric oxide levels in patients with chronic rhinosinusitis

2018 ◽  
Vol 141 (2) ◽  
pp. AB270
Author(s):  
Kanako Yoshida ◽  
Tetsuji Takabayashi ◽  
Masafumi Sakashita ◽  
Yoshimasa Imoto ◽  
Norihiko Narita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Eosinophilic Inflammation ◽  
Nasal Nitric Oxide

Two Patterns of Changes in Nasal Nitric Oxide after Lysine Aspirin Nasal Challenge in Patients with Aspirin-exacerbated Respiratory Disease

2012 ◽  
Vol 26 (6) ◽  
pp. 428-432 ◽  
Author(s):  
Damian Tworek ◽  
Izabela Kuprys-Lipinska ◽  
Wioletta Pietruszewska ◽  
Piotr Kuna
Keyword(s):  
Nitric Oxide ◽  
Positive Result ◽  
Respiratory Disease ◽  
Nasal Polyps ◽  
Control Groups ◽  
Control Solution ◽  
Time Points ◽  
Nasal Nitric Oxide ◽  
Nasal Challenge ◽  
Aspirin Exacerbated Respiratory Disease

Background Nasal nitric oxide (nNO) levels after nasal lysine acetylsalicylic acid (lys-ASA) challenge have not been determined. This study was designed to determine a pattern of changes after lys-ASA challenge in aspirin-exacerbated respiratory disease (AERD) patients and to evaluate the usefulness of nNO measurements in the assessment of lys-ASA nasal challenge outcome. Methods Eighteen patients with aspirin hypersensitivity, nasal polyps, and asthma were included. Aspirin-tolerant control groups consisted of 10 healthy volunteers without asthma and nasal polyps and 10 patients with nasal polyps without asthma. All subjects underwent nasal challenge with lys-ASA. nNO was measured before and 1, 2, 4, and 24 hours after control solution and lys-ASA administration. Results A significant fall in nNO levels was noted in AERD patients with a positive result to challenges at time points 1 hour (p = 0.0033), 2 hours (p = 0.0033), and 3 hours (p = 0.026) after lys-ASA. A trend toward higher nNO concentrations was observed after lys-ASA challenge at the 2-hour (p = 0.018) and 4-hour (p = 0.018) time points compared with baseline in subjects with AERD and a clinically negative re to the challenge. No significant changes in nNO levels after the challenge were observed in control groups. The combined increase and decrease in nNO levels gave the sensitivity as 0.94 and specificity 1.00 at best. Conclusion nNO levels decrease after lys-ASA nasal challenge in subjects with AERD and a clinically positive result of the challenge. An unexpected trend toward an increase in nNO levels is observed in subjects with AERD and a clinically negative result of the challenge.

scholarly journals Perspective of the regulatory and functional roles of nasal nitric oxide in chronic rhinosinusitis

2019 ◽  
Vol 37 (4) ◽  
pp. 233-239
Author(s):  
Kota Takemoto ◽  
Sachio Takeno ◽  
Atsuko Ohtani ◽  
Daisuke Takahara ◽  
Manabu Nishida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Functional Roles ◽  
Nasal Nitric Oxide

scholarly journals Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis

2013 ◽  
Vol 66 (1) ◽  
pp. 92-96 ◽  
Author(s):  
Yogesh G. Dabholkar ◽  
Akanksha A. Saberwal ◽  
Haritosh K. Velankar ◽  
Adip K. Shetty ◽  
Nilesh P. Chordia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Computed Tomography ◽  
Chronic Rhinosinusitis ◽  
Nasal Nitric Oxide

scholarly journals Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis

2019 ◽  
Vol 68 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Kanako Yoshida ◽  
Tetsuji Takabayashi ◽  
Yoshimasa Imoto ◽  
Masafumi Sakashita ◽  
Norihiko Narita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Nasal Nitric Oxide ◽  
Eosinophilic Chronic Rhinosinusitis
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