scholarly journals Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis

2019 ◽  
Vol 68 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Kanako Yoshida ◽  
Tetsuji Takabayashi ◽  
Yoshimasa Imoto ◽  
Masafumi Sakashita ◽  
Norihiko Narita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Nasal Nitric Oxide ◽  
Eosinophilic Chronic Rhinosinusitis

Predictive and Diagnostic Value of Nasal Nitric Oxide in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

2020 ◽  
Vol 181 (11) ◽  
pp. 853-861
Author(s):  
Hao Lv ◽  
Pei-Qiang Liu ◽  
Rong Xiang ◽  
Wei Zhang ◽  
Shi-Ming Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Upper Airway ◽  
Central China ◽  
Clinical Parameters ◽  
Total Ige ◽  
Nasal Nitric Oxide ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Plasma Cytokines

<b><i>Background:</i></b> A hallmark of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is mucosal eosinophil-predominant inflammation. Nasal nitric oxide (nNO) is a known biomarker of eosinophilic inflammation in the upper airway. However, the utility of nNO measurement in the upper airway remains controversial. The present study aimed to compare the use of other clinical parameters with nNO to prediagnose patients with eCRSwNP from Central China. <b><i>Methods:</i></b> From June 2019 to December 2019, 70 patients with CRSwNP undergoing endoscopic sinus surgery and 30 healthy subjects were enrolled. nNO measurements were performed in all of these subjects. Computed tomography scans, full blood count with differential analysis, and determination of total immunoglobulin E (total IgE) and plasma cytokines were performed before surgery. Receiver operating characteristic curves and logistic regression analysis were used to assess the predictive potential of the clinical parameters. <b><i>Results:</i></b> We recruited 24 patients with eCRSwNP and 46 with noneosinophilic CRSwNP (non-eCRSwNP). In patients with eCRSwNP, nNO levels were significantly higher than those in patients with non-eCRSwNP (<i>p</i> &#x3c; 0.0001). Blood eosinophil percentages and counts, total IgE, and CT-derived ethmoid sinus and maxillary sinus ratio (E/M ratio) were all significantly higher compared with those in patients with non-eCRSwNP (<i>p</i> &#x3c; 0.05). To diagnose eCRSwNP, the highest area under the curve (0.803) was determined for nNO. At a cutoff of &#x3e;329 parts per billion (ppb), the sensitivity was 83.30% and the specificity was 71.70%. However, the levels of plasma cytokines Th1/Th2 were not significantly different between the histological types of CRSwNP (<i>p</i> &#x3e; 0.05). <b><i>Conclusion:</i></b> Measurement of nNO is useful for the early diagnosis of eCRSwNP.

scholarly journals Eosinophilic inflammation of the paranasal sinuses and reduced nasal nitric oxide levels in patients with chronic rhinosinusitis

2018 ◽  
Vol 141 (2) ◽  
pp. AB270
Author(s):  
Kanako Yoshida ◽  
Tetsuji Takabayashi ◽  
Masafumi Sakashita ◽  
Yoshimasa Imoto ◽  
Norihiko Narita ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Paranasal Sinuses ◽  
Eosinophilic Inflammation ◽  
Nasal Nitric Oxide

scholarly journals Perspective of the regulatory and functional roles of nasal nitric oxide in chronic rhinosinusitis

2019 ◽  
Vol 37 (4) ◽  
pp. 233-239
Author(s):  
Kota Takemoto ◽  
Sachio Takeno ◽  
Atsuko Ohtani ◽  
Daisuke Takahara ◽  
Manabu Nishida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Rhinosinusitis ◽  
Functional Roles ◽  
Nasal Nitric Oxide

scholarly journals Correlation of Nasal Nitric Oxide Measurement with Computed Tomography Findings in Chronic Rhinosinusitis

2013 ◽  
Vol 66 (1) ◽  
pp. 92-96 ◽  
Author(s):  
Yogesh G. Dabholkar ◽  
Akanksha A. Saberwal ◽  
Haritosh K. Velankar ◽  
Adip K. Shetty ◽  
Nilesh P. Chordia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Computed Tomography ◽  
Chronic Rhinosinusitis ◽  
Nasal Nitric Oxide

Lower Airway Inflammation in Eosinophilic Chronic Rhinosinusitis as Determined by Exhaled Nitric Oxide

2017 ◽  
Vol 173 (4) ◽  
pp. 225-232 ◽  
Author(s):  
Rumi Kambara ◽  
Takafumi Minami ◽  
Hitoshi Akazawa ◽  
Fumio Tsuji ◽  
Takanobu Sasaki ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Airway Inflammation ◽  
Chronic Rhinosinusitis ◽  
Exhaled Nitric Oxide ◽  
Lower Airway ◽  
Eosinophilic Chronic Rhinosinusitis
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