Patient-Ventilator Interaction During Noninvasive Ventilation in Subjects With Exacerbation of COPD: Effect of Support Level and Ventilator Mode

2020 ◽  
Vol 65 (9) ◽  
pp. 1315-1322
Author(s):  
Eline Oppersma ◽  
Jonne Doorduin ◽  
Lisanne H Roesthuis ◽  
Johannes G van der Hoeven ◽  
Peter H Veltink ◽  
...  
Keyword(s):  
Noninvasive Ventilation ◽  
Support Level ◽  
Ventilator Mode ◽  
Exacerbation Of Copd ◽  
Effect Of Support

scholarly journals Nasal high-flow oxygen versus noninvasive ventilation in acute exacerbation of COPD: protocol for a randomised noninferiority clinical trial

2020 ◽  
Vol 6 (4) ◽  
pp. 00114-2020
Author(s):  
Athanasia Papalampidou ◽  
Eleni Bibaki ◽  
Stylianos Boutlas ◽  
Ioannis Pantazopoulos ◽  
Nikolaos Athanasiou ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Noninvasive Ventilation ◽  
High Flow ◽  
Line Treatment ◽  
First Line ◽  
Hypercapnic Respiratory Failure ◽  
Acute Exacerbation Of Copd ◽  
High Flow Oxygen ◽  
Exacerbation Of Copd ◽  
First Line Treatment

BackgroundNoninvasive ventilation (NIV) is considered as the first-line treatment for acute exacerbation of COPD (AECOPD) complicated by respiratory acidosis. Recent studies demonstrate a role of nasal high-flow oxygen (NHF) in AECOPD as an alternative treatment in patients intolerant to NIV or with contraindications to it.AimThe study aimed to evaluate whether NHF respiratory support is noninferior compared to NIV in respect to treatment failure, defined as need for intubation or change to alternative treatment group, in patients with AECOPD and mild-to-moderate acute or acute-on-chronic hypercapnic respiratory failure.MethodsWe designed a multicentre, prospective, randomised trial on patients with AECOPD, who have pH<7.35 but >7.25 and PaCO2 >45 mmHg, in whom NIV is indicated as a first-line treatment. According to power analysis, 498 participants will be required for establishing noninferiority of NHF compared to NIV. Patients will be randomly assigned to receive NIV or NHF. Treatment will be adjusted to maintain SpO2 between 88%–92% for both groups. Arterial blood gases, respiratory variables, comfort, dyspnoea score and any pulmonary or extrapulmonary complications will be assessed at baseline, before treatment initiation, and at 1, 2, 4, 6, 12, 24, 48 h, then once daily from day 3 to patient discharge, intubation or death.ConclusionGiven the increasing number of studies demonstrating the physiological effects of NHF in COPD patients, we hypothesise that NHF respiratory support will be noninferior to NIV in patients with AECOPD and mild-to-moderate acute or acute on chronic hypercapnic respiratory failure.

scholarly journals Noninvasive ventilation in acute exacerbation of COPD: Homer is close to shore

2021 ◽  
Vol 57 ◽  
pp. 160-160
Author(s):  
Umur Hatipoğlu ◽  
Laith Ghazala ◽  
Manshi Li ◽  
Xiaofeng Wang ◽  
Abhijit Duggal
Keyword(s):  
Acute Exacerbation ◽  
Noninvasive Ventilation ◽  
Acute Exacerbation Of Copd ◽  
Exacerbation Of Copd

scholarly journals A Controlled Trial of Noninvasive Positive Pressure Ventilation (NIPPV) in Patients of COPD with Respiratory Failure

2013 ◽  
Vol 1 (2) ◽  
pp. 86-92
Author(s):  
Rawshan Arra Khanam ◽  
Md Ashraful Haque ◽  
Shah Md Saifur Rahman ◽  
Md Ali Hossain ◽  
Md Rashidul Hassan
Keyword(s):  
Respiratory Failure ◽  
Endotracheal Intubation ◽  
Noninvasive Ventilation ◽  
Positive Pressure Ventilation ◽  
Controlled Trial ◽  
Noninvasive Positive Pressure Ventilation ◽  
Positive Pressure ◽  
Exacerbation Of Copd ◽  
Standard Medical Treatment ◽  
Standard Treatment Group

Objective : To assess the role of noninvasive positive pressure ventilation (NIPPV) in patients of acute exacerbation of COPD with respiratory failure, also to reduce endotracheal intubation (ETI) and the frequency of complications associated with ETI. Materials and Methods : Prospective, single blind, randomized controlled trial study (RCT) comparing the effect of combined standard medical treatment and noninvasive positive pressure ventilation with standard medical treatment alone in patients admitted to National Institute of Diseases of the Chest and Hospital (NIDCH), Mohakhali, Bangladesh over a 12-month period. Results : A total number of 60 patients of acute exacerbation of COPD with type II respiratory failure were enrolled from inpatient department of Institute of Diseases of the Chest and Hospital (NIDCH), Mohakhali, Bangladesh. A total of 30 (thirty) were randomly assigned to standard therapy and 30 (thirty) to noninvasive ventilation. The two groups had similar clinical characteristics on admission to the hospital. The use of noninvasive ventilation significantly reduced the need for endotracheal intubation (which was dictated by objective criteria): 12 of 30 patients (40.0%) in the noninvasive- ventilation group were intubated, as compared with 22 of 30 patients (73.3%) in the standard-treatment group (P=0.01). In addition, the frequency of complications was significantly lower in the noninvasive-ventilation group. The mean ( ± SD) hospital stay was significantly shorter for patients receiving noninvasive ventilation. 19.2±5.7days vs. 23.5±8.3 days, (P 0.02). The in-hospital mortality rate was also significantly reduced with noninvasive ventilation, 5 of 30 patients (16.7%) in the noninvasive- ventilation group died in the hospital, as compared with13 of 30 (43.3%) in the standard-treatment group( P 0.04) Conclusions : In selected patients with acute exacerbations of chronic obstructive pulmonary disease, noninvasive ventilation can reduce the need for endotracheal intubation, complications, the length of the hospital stay, and the in-hospital mortality rate. DOI: http://dx.doi.org/10.3329/bccj.v1i2.17201 Bangladesh Crit Care J September 2013; 1 (2): 86-92

Predictive factors of noninvasive ventilation failure for acute exacerbation of COPD

2020 ◽  
Author(s):  
Maria João Freitas Ferreira Araújo ◽  
Rita Ortiga ◽  
Diana Pimenta ◽  
Ana Luísa Vieira ◽  
Lurdes Ferreira
Keyword(s):  
Acute Exacerbation ◽  
Predictive Factors ◽  
Noninvasive Ventilation ◽  
Acute Exacerbation Of Copd ◽  
Ventilation Failure ◽  
Exacerbation Of Copd
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