scholarly journals Peak Oxygen Uptake and Mortality in Cystic Fibrosis: Systematic Review and Meta-Analysis

2018 ◽  
Vol 64 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Fernanda Maria Vendrusculo ◽  
João Paulo Heinzmann-Filho ◽  
Juliana Severo da Silva ◽  
Margarita Perez Ruiz ◽  
Márcio Vinícius Fagundes Donadio
Keyword(s):  
Systematic Review ◽  
Cystic Fibrosis ◽  
Oxygen Uptake ◽  
Meta Analysis ◽  
Peak Oxygen Uptake

MO611CARDIOPULMONARY RESERVE EXAMINED WITH CARDIOPULMONARY EXERCISE TESTING IN INDIVIDUALS WITH AND WITHOUT CHRONIC KIDNEY DISEASE; A SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Eva Pella ◽  
Marieta Theodorakopoulou ◽  
Afroditi Boutou ◽  
Maria Eleni Alexandrou ◽  
Dimitra Bakaloudi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Oxygen Uptake ◽  
Meta Analysis ◽  
Cardiopulmonary Exercise Testing ◽  
Peak Oxygen Uptake ◽  
Cardiopulmonary Exercise ◽  
Patients With Heart Failure

Abstract Background and Aims Patients with chronic kidney disease (CKD) often present with reduced physical activity and exercise performance due to a number of factors relevant to co-existing disturbances of the cardiac, nervous and muscular systems. Cardiopulmonary exercise testing (CPET) is widely applied in daily clinical practice used for clinical evaluation of exercise intolerance and related symptoms (i.e. dyspnea, fatigue), as well risk stratification, and other applications in several medical fields. Method This is a systematic review and meta-analysis of studies which used CPET technology in adult patients with CKD to examine cardiopulmonary reserve in individuals with versus individuals without CKD. The primary outcome was peak oxygen uptake (VO2peak). Literature search involved PubMed, Web of Science and Scopus databases; manual search of article references and of grey literature was also performed. Newcastle-Ottawa Scale was applied to evaluate the quality of retrieved studies. Results From an initial 4944 literature records, we identified 29 studies fulfilling the inclusion criteria; of these, 25 studies with complete data including 2213 participants were included in final meta-analysis. Peak oxygen uptake (VO2peak) was significantly lower in CKD patients compared to controls without CKD (standardized-mean-difference, SMD:-1.40, 95%CI[-1.68, -1.13]) (Figure). Oxygen consumption at anaerobic threshold (VO2AT) (SMD:-1.06, 95%CI[-1.34, -0.79]), maximum workload (weighted-mean-difference, WMD:-58.26, 95%CI[-74.14, -42.38]) and respiratory exchange ratio (RER) (WMD:-0.02, 95%CI[-0.05, 0.01]) were also impaired in CKD patients compared to non-CKD individuals. In 3 studies comparing patients with CKD versus patients with heart failure without CKD VO2peak was higher in the former (WMD:6.60, 95%CI[3.02, 10.18]). Sensitivity analyses confirmed the robustness of these findings. Conclusion VO2peak and other commonly analyzed CPET variables were lower in CKD patients compared to controls, indicating reduced functional cardiopulmonary reserve in the former. In contrast, CKD patients performed better when compared patients with heart failure.

Resistance exercise enhances oxygen uptake without worsening cardiac function in patients with systolic heart failure: a systematic review and meta-analysis

2017 ◽  
Vol 23 (1) ◽  
pp. 73-89 ◽  
Author(s):  
Francisco V. Santos ◽  
Gaspar R. Chiappa ◽  
Sergio Henrique Rodolpho Ramalho ◽  
Alexandra Correa Gervazoni Balbuena de Lima ◽  
Fausto Stauffer Junqueira de Souza ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Oxygen Uptake ◽  
Cardiac Function ◽  
Resistance Exercise ◽  
Meta Analysis ◽  
Systolic Heart Failure

Risk factors leading to pulmonary exacerbation in patients with cystic fibrosis: A systematic review

2021 ◽  
Vol 71 (9) ◽  
Author(s):  
Danish Abdul Aziz ◽  
Syeda Khadija Fatima ◽  
Hasan Nawaz Tahir
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cystic Fibrosis ◽  
Meta Analysis ◽  
Nutritional Deficiencies ◽  
Pulmonary Exacerbation ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Factors Associated ◽  
Randomised Controlled

Objective: To ascertain major risk factors associated with pulmonary exacerbation and pulmonary function decline in cystic fibrosis. Method: The systematic review was conducted at Aga Khan University, Karachi, in September 2018, and comprised electronic search of PubMed, Ovid, Science Direct and Cumulative Index of Nursing and Allied Health Literature databases of studies conducted from January 1990 to September 2018 which were categorised into 3 sets; 1990-98, 1999-2007 and 2008-18. Studies included for review focussed on articles with pulmonary exacerbation as the health outcome indicator, and had diagnosis of cystic fibrosis as the inclusion criteria, while risk factors were the exposure terms used in the search process. References in bibliographies of the included studies were also systematically searched for relevant documents. Results: Of the 60 studies obtained, 31(51.7%) were selected; 2(6.45%) from 1990-98, 7(22.58%) from 1999-2007 and 22(70.96%) from 2008-18. Overall, 17(54.83%) were cohort studies, 7(22.5%) were cross-sectional studies, 3(9.6%) were case-control studies, 3(9.6%) were randomised controlled trials and 1(3.2%) was systematic review and meta-analysis. In terms of major risk factors, genetic mutations were cited by 4(12.9%) studies, infections and inflammatory biomarkers by 15(48.4%), nutritional deficiencies by 9(29%) and geographical and socioeconomic status by 3(9.6%) studies. Conclusion: Early identification and recognition of risk factors associated with pulmonary exacerbation can have an explicit impact on its management, leading to decreased morbidity and mortality burden in cystic fibrosis cases. Key Words: Pulmonary exacerbation, Cystic fibrosis, Risk factors, Systematic review. Continuous...

scholarly journals Sleep disorders in cystic fibrosis: A systematic review and meta-analysis

2020 ◽  
Vol 51 ◽  
pp. 101279 ◽  
Author(s):  
Joel Reiter ◽  
Alex Gileles-Hillel ◽  
Malena Cohen-Cymberknoh ◽  
Dennis Rosen ◽  
Eitan Kerem ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cystic Fibrosis ◽  
Sleep Disorders ◽  
Meta Analysis

scholarly journals Physical exercise training in patients with a Fontan circulation: A systematic review

2020 ◽  
pp. 204748732094286
Author(s):  
Linda E Scheffers ◽  
Linda EM vd Berg ◽  
Gamida Ismailova ◽  
Karolijn Dulfer ◽  
Johanna JM Takkenberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Exercise Training ◽  
Oxygen Uptake ◽  
Cardiac Function ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Training Intervention ◽  
Fontan Patients

Background Patients with a Fontan circulation have a reduced exercise capacity, which is an important prognostic predictor of morbidity and mortality. A way to increase exercise capacity in Fontan patients might be exercise training. This systematic review assesses the effects of exercise training investigated in Fontan patients in order to provide an overview of current insights. Design and methods Studies evaluating an exercise training intervention in Fontan patients published up to February 2020 were included in this systematic review. Results From 3000 potential studies, 16 studies reported in 22 publications met the inclusion criteria. In total, 264 Fontan patients with mean age range 8.7–31 years, were included. Different training types including inspiratory muscle training, resistance training and aerobic training were investigated. Main outcome measures reported were peak oxygen uptake, cardiac function, lung function, physical activity levels and quality of life. Peak oxygen uptake increased significantly in 56% of the studies after training with an overall mean increase of +1.72 ml/kg/min (+6.3%). None of the studies reported negative outcome measures related to the exercise programme. In four studies an adverse event was reported, most likely unrelated to the training intervention. Conclusions Exercise training in Fontan patients is most likely safe and has positive effects on exercise capacity, cardiac function and quality of life. Therefore exercise training in Fontan patients should be encouraged. Further studies are required to assess the optimal training type, intensity, duration and long-term effects.

Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis

Pancreatology ◽  
2020 ◽  
Vol 20 ◽  
pp. S121
Author(s):  
M. Juhász ◽  
O. Varannai ◽  
D. Németh ◽  
K. Ocskay ◽  
Z. Szakács ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cystic Fibrosis ◽  
Vitamin D ◽  
Meta Analysis ◽  
Vitamin D Supplementation

Relationship between FEV1 and peak oxygen uptake in children with cystic fibrosis

2005 ◽  
Vol 40 (4) ◽  
pp. 324-329 ◽  
Author(s):  
Paul Pianosi ◽  
John LeBlanc ◽  
Anthony Almudevar
Keyword(s):  
Cystic Fibrosis ◽  
Oxygen Uptake ◽  
Peak Oxygen Uptake
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