scholarly journals A New Simple, Personalized, and Quantitative Empirical Method for Determining 131I Activity in Treating Graves’ Disease

2020 ◽  
Vol 16 (3) ◽  
pp. 329-333
Author(s):  
F Xu
Keyword(s):  
Empirical Method ◽  
Graves Disease ◽  
131I Activity

Administration of additional inactive iodide during radioiodine therapy for Graves' disease

2007 ◽  
Vol 46 (03) ◽  
pp. 77-84 ◽  
Author(s):  
D. Moka ◽  
U. Reinholz ◽  
M. Schmidt ◽  
K. Schomäcker ◽  
H. Schicha ◽  
...  
Keyword(s):  
Patient Group ◽  
Half Life ◽  
Radioiodine Therapy ◽  
Antithyroid Drugs ◽  
Graves Disease ◽  
131I Activity ◽  
Short Half Life ◽  
Thyroid Dose ◽  
Group A ◽  
Group B

Summary Aim: Graves' hyperthyroidism and antithyroid drugs empty the intrathyroid stores of hormones and iodine. The consequence is rapid 131I turnover and impending failure of radioiodine therapy. Can administration of additional inactive iodide improve 131I kinetics? Patients, methods: Fifteen consecutive patients, in whom the 48 h post-therapeutically calculated thyroid dose was between 150 and 249 Gy due to an unexpectedly short half-life, received 3 × 200 μg inactive potassium-iodide (127I) daily for 3 days (Group A), while 17 consecutive patients with a thyroid dose of ≥ 250 Gy (Group B) served as the non-iodide group. 48 hours after 131I administration (M1) and 4 or 5 days later (M2) the following parameters were compared: effective 131I half-life, thyroid dose, total T3, total T4, 131I-activity in the T3- and T4-RIAs. Results: In Group A, the effective 131I half-life M1 before iodine (3.81 ± 0.93 days) was significantly (p <0.01) shorter than the effective 131I half-life M2 (4.65 ± 0.79 days). Effective 131I half-life M1 correlated with the benefit from inactive 127I (r = –0.79): Administration of 127I was beneficial in patients with an effective 131I half-life M1 of <3 or 4 days. Patients from Group A with high initial specific 131I activity of T3 and T4 showed lower specific 131I activity after addition of inactive iodine compared with patients from the same group with a lower initial specific 131I activity of T3 and T4 and compared with the patient group B who was given no additional inactive iodide. This correlation was mathematically described and reflected in the flatter gradient in Group A (y = 0.5195x + 0.8727 for 131I T3 and y = 1.0827x – 0.4444 for 131I T4) and steeper gradient for Group B (y = 0.6998x + 0.5417 for 131I T3 and y = 1.3191x – 0.2901 for 131I T4). Radioiodine therapy was successful in all 15 patients from Group A. Conclusion: The administration of 600 μg inactive iodide for three days during radioiodine therapy in patients with Graves' hyperthyroidism and an unexpectedly short half-life of <3 or 4 days was a safe and effective alternative to the administration of a second radioiodine capsule

Optimized radioiodine therapy for Graves?? disease: Two MIRD-based models for the computation of patient-specific therapeutic 131I activity

2006 ◽  
Vol 27 (7) ◽  
pp. 559-566 ◽  
Author(s):  
Thomas Carlier ◽  
Pierre-Yves Salaun ◽  
Marie-B??atrice Cavarec ◽  
Fr??d??ric Valette ◽  
Alexandre Turzo ◽  
...  
Keyword(s):  
Radioiodine Therapy ◽  
Patient Specific ◽  
Graves Disease ◽  
131I Activity

Quantification of Silica Uptake by Alveolar Macrophages - An Emperical Scanning Electron Microprobe Method

1982 ◽  
Vol 40 ◽  
pp. 332-333
Author(s):  
V. V. Damiano ◽  
R. P. Daniele ◽  
H. T. Tucker ◽  
J. H. Dauber
Keyword(s):  
Quantitative Analysis ◽  
Alveolar Macrophages ◽  
Bulk Sample ◽  
Silica Particles ◽  
Empirical Method ◽  
Phagocytic Cells ◽  
Calibration Standards ◽  
X Ray ◽  
Accurate Quantitative Analysis ◽  
Scanning Electron

An important example of intracellular particles is encountered in silicosis where alveolar macrophages ingest inspired silica particles. The quantitation of the silica uptake by these cells may be a potentially useful method for monitoring silica exposure. Accurate quantitative analysis of ingested silica by phagocytic cells is difficult because the particles are frequently small, irregularly shaped and cannot be visualized within the cells. Semiquantitative methods which make use of particles of known size, shape and composition as calibration standards may be the most direct and simplest approach to undertake. The present paper describes an empirical method in which glass microspheres were used as a model to show how the ratio of the silicon Kα peak X-ray intensity from the microspheres to that of a bulk sample of the same composition correlated to the mass of the microsphere contained within the cell. Irregular shaped silica particles were also analyzed and a calibration curve was generated from these data.

Abstract #1064 Biotin Supplementation Mimicking Graves’ Disease

2018 ◽  
Vol 24 ◽  
pp. 252
Author(s):  
Matthew Gorris ◽  
Brittany Henderson
Keyword(s):  
Graves Disease ◽  
Biotin Supplementation
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