Evaluation of Antiurolithiatic Effect of Pedalium murex Fruit Extract in Ethylene Glycol-induced Nephrolithiasis in Rat

2016 ◽  
Vol 78 (2) ◽  
Author(s):  
P K Patel ◽  
B A Vyas
Keyword(s):  
Ethylene Glycol ◽  
Fruit Extract ◽  
Pedalium Murex

scholarly journals Curative Effects of Ethanol Extract of Prosopis Farcta (Syrian Mesquite) Against Ethylene Glycol Induced Urolithiasis in Male Albino Rats

2021 ◽  
Vol 9 (2) ◽  
pp. 89-96
Author(s):  
Kowan M. Ahmed ◽  
Sarbast A. Mahmud
Keyword(s):  
Ethylene Glycol ◽  
Tap Water ◽  
Control Group ◽  
Albino Rats ◽  
Therapeutic Effects ◽  
Fruit Extract ◽  
Kidney Weight ◽  
Prosopis Farcta ◽  
Group A ◽  
Group B

The present study was designed to evaluate the antiurolithiatic activity of Prosopis farcta (P. farcta) ethanol fruit extract in ethylene glycol (EG) induced urolithiasis in male albino rats. Lithiasis was induced by oral administration of EG 1% in male albino rats for 28 days. Seventy eight male albino rats weighing 250-300g were used and divided into six experimental groups. Group A is a control group received standard rat chow and tap water ad libitum, while, rest of groups namely group B, C, D, E, F animals received 1% EG in water for 28 days, then from day 15 to day 28 in addition to EG administration, group C received cystone, group D, E and F received 100, 200 and 300 mg/kg body weight (B.W.) of ethanol fruit extract of P. farcta respectively. On day 28, blood was collected for serum biochemical (serum uric acid, creatinine, urea, electrolytes measurements, malondialdehyde (MDA) and superoxide dismutase (SOD)) determinations. While urine was collected to microscopic analysis of formed crystals besides the kidney weight/ B.W. ratio and B.W. gain/ loss values were determined. Intermediate dose (200mg/kg B.W.) of P. farcta extract significantly decreased serum creatinine, urea, MDA and non-significantly recovered SOD toward control value in group E as compared to group B, also significant elevation in kidney weight/ B.W. ratio and reduction in B.W. gains in group B occurred as compared with group A. In conclusion: P. farcta fruit extract has potentially therapeutic effects on EG induced kidney stone which can be used as effective antiurolithiatic agent rather than cystone.

Effect of Terminalia chebula fruit extract on ethylene glycol induced urolithiasis in rats

2012 ◽  
Vol 2 (3) ◽  
pp. 99-103 ◽  
Author(s):  
Anil T. Pawar ◽  
Gayatri D. Gaikwad ◽  
Kavita S. Metkari ◽  
Kiran A. Tijore ◽  
Jaydip V. Ghodasara ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Terminalia Chebula ◽  
Fruit Extract

scholarly journals A novel bioactive molecule 5-β-Hydroxyltridecanyl benzoate identified in Pedalium Murex L. (Gokhru) fruit extracts showed antifungal activity against Sclerotinia sclerotiorum

2018 ◽  
Author(s):  
Gulshan Chaudhary ◽  
Nutan Kaushik ◽  
Pallavolu Maheswara Reddy
Keyword(s):  
Sclerotinia Sclerotiorum ◽  
Plant Protection ◽  
Scale Up ◽  
Fruit Extract ◽  
Climatic Zones ◽  
Fruit Extracts ◽  
Single Compound ◽  
Bioactive Molecule ◽  
Pedalium Murex

AbstractFruits of Pedalium murex known as, ‘Gokhru’ is predominantly used in Ayurveda for its aphrodisiac properties and use in treatment of urological orders. However till now, bioactivity of this fruit has not been documented for plant protection against phytopathogenes, Hence in this regard, we investigated antimicrobial activity of P. murex fruit extracts (isolated from the different agro climatic zones of India) were tested against twelve microbial phytopathogens. From 29 fruit extracts, only 13 were found to be active against three pathogens viz. Botrytis cinerea, Rhizoctonia solani, and Sclerotinia sclerotiorum. Among the nine TLC fractions only one showed presence of a single peak, thus presence of a single compound in the crude extract. Based on lower IC50 value (328 μg/ml) the crude fruit extract collected from Indore region was further characterized. Evaluation against screened phytopathogens indicates its activity. Further, structural characterization of this compound using FTIR and NMR revealed it to be a novel compound i.e. 5-β-Hydroxyl tridecanyl benzoate. Our study paves a way to investigate effective dose of P. murex fruit extracts to utilize in plant protection programs. In future, a better method is required to scale up the process of bioactive molecule (5-β-Hydroxyl tridecayl benzoate) extraction from P. murex or for its chemical synthesis.

Freeze-substituted fungal cells of Nectria haematococca: A comparison of the macroconidial walls of the adhesion-competent wild type with an adhesion-reduced mutant

1990 ◽  
Vol 48 (3) ◽  
pp. 688-689
Author(s):  
Thecan Caesar-Ton That ◽  
Lynn Epstein
Keyword(s):  
Freeze Substitution ◽  
Uranyl Acetate ◽  
Wild Type ◽  
Nectria Haematococca ◽  
Fruit Extract ◽  
Dialysis Tubing ◽  
Tube Emergence ◽  
Contrast Microscopy ◽  
In The Wild ◽  
Freeze Damage

Nectria haematococca mating population I (anamorph, Fusarium solani) macroconidia attach to its host (squash) and non-host surfaces prior to germ tube emergence. The macroconidia become adhesive after a brief period of protein synthesis. Recently, Hickman et al. (1989) isolated N. haematococca adhesion-reduced mutants. Using freeze substitution, we compared the development of the macroconidial wall in the wild type in comparison to one of the mutants, LEI.Macroconidia were harvested at 1C, washed by centrifugation, resuspended in a dilute zucchini fruit extract and incubated from 0 - 5 h. During the incubation period, wild type macroconidia attached to uncoated dialysis tubing. Mutant macroconidia did not attach and were collected on poly-L-lysine coated dialysis tubing just prior to freezing. Conidia on the tubing were frozen in liquid propane at 191 - 193C, substituted in acetone with 2% OsO4 and 0.05% uranyl acetate, washed with acetone, and flat-embedded in Epon-Araldite. Using phase contrast microscopy at 1000X, cells without freeze damage were selected, remounted, sectioned and post-stained sequentially with 1% Ba(MnO4)2 2% uranyl acetate and Reynold’s lead citrate. At least 30 cells/treatment were examined.

Selective Inos and COX-2 inhibition of Morinda Citrifolia (Noni) fruit extract in rat gastric ulcerated mucosa

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
S Mahattanadul ◽  
S Nima ◽  
S Kasiwong ◽  
S Tewtrakul ◽  
P Tansakul
Keyword(s):  
Morinda Citrifolia ◽  
Fruit Extract ◽  
Cox 2
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