scholarly journals Neurobehavioral Alterations and Brain Creatine Kinase System Changes in Chronic Renal Failure Induced Male Wistar Rats: Impact of Erythropoietin Supplementation

2015 ◽  
Vol 07 (02) ◽  
Author(s):  
Karthick N Alwin D
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Chronic Renal Failure ◽  
Wistar Rats ◽  
System Changes ◽  
Male Wistar Rats ◽  
Brain Creatine Kinase

Spurious brain creatine kinase in serum from patients with renal disease.

1978 ◽  
Vol 24 (9) ◽  
pp. 1636-1638 ◽  
Author(s):  
R B Coolen ◽  
R Herbstman ◽  
P Hermann
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Renal Disease ◽  
Normal Serum ◽  
Disease States ◽  
Low Concentrations ◽  
Brain Creatine Kinase ◽  
End Stage ◽  
Increased Activity

Abstract Creatine kinase isoenzyme I(BB) is generally not detectable in normal serum, and its occurrence in serum has been documented in only a few disease states. In particular, increased activity of this isoenzyme has been reported in association with chronic renal failure, hemodialysis, and renal transplantation. The present study demonstrates that the apparent creatine kinase observed in the serum of such renal patients is an artifact, observed as a result of measuring creatine kinase isoenzymes by fluorescence. Our observations resemble those of McKenzie et al. [Clin. Chim. Acta 70, 333(1976)] concerning an artifact in the fluorometric determination of lactate dehydrogenase isoenzymes in the sera of patients with end-stage renal failure. The artifact binds to albumin, is not a protein, and occurs in some normal sera at very low concentrations. This artifact can be mistakenly identified as isoenzyme I in renal-disease patients if CK isoenzymes are determined fluorometrically.

scholarly journals EFFECT OF CHRONIC RENAL DYSFUNCTION ON THE PERMEABILITY OF THE COLON TO WATER AND ELECTROLYTES: EXPERIMENTAL STUDY IN RATS

2019 ◽  
Vol 32 (4) ◽  
Author(s):  
Elionai Gomes FREIRE ◽  
José Cirlânio Sousa ALBUQUERQUE ◽  
Israel Pinto LEAL ◽  
Nayara Alves SOUSA ◽  
José Ronaldo Vasconcelos da GRAÇA
Keyword(s):  
Experimental Study ◽  
Renal Failure ◽  
Polyethylene Glycol ◽  
Gastrointestinal Tract ◽  
Wistar Rats ◽  
The Other ◽  
Male Wistar Rats ◽  
Progression Of Renal Failure ◽  
Colonic Secretion ◽  
Secretory Capacity

ABSTRACT Background: Renal insufficiency is a disease that affects several organs by provoking hypervolemia and uremia. The disease reaches more than 500 million people worldwide and few studies bring their influence on the gastrointestinal tract. Aim: To evaluate the influence of 5/6 nephrectomy-induced hypervolemia on colonic permeability to water and electrolytes. Method: Sixty male Wistar rats weighing between 280-300 g were divided into three groups: 3, 7 and 14 days after nephrectomy, each one having a false-operated/control and partially nephrectomized. For colonic permeability they were submitted to colonic perfusion with a solution of Tyroad containing phenolphthalein. Differences among the concentrations of Na+, K+ and Cl- were used to calculate the rate of colonic permeability for the electrolytes. Phenolphthalein concentrations were used to evaluate the rate of secretion and water absorption. Results: The colonic secretion of water and electrolytes occurred expressively in the group seven days after nephrectomy. Hemodynamic and biochemical assessments determined the progression of renal failure in all three groups and polyethylene glycol was shown to be effective in reversing the secretory capacity of the colon. Conclusion: Hypervolemia established after 7 days post-nephrectomy 5/6 caused marked colonic secretion for water and electrolytes. The organism presents progressive colonic secretion as the blood volume increases; on the other hand, polyethylene glycol was able to revert this secretory framework of the colon to water and electrolytes by reversing the hypervolemia.

Natural fluorescence in serum of patients with chronic renal failure not to be confused with creatine kinase-BB isoenzyme.

1978 ◽  
Vol 24 (3) ◽  
pp. 492-494 ◽  
Author(s):  
H Aleyassine ◽  
D B Tonks ◽  
M Kaye
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Chronic Renal Failure ◽  
Cellulose Acetate ◽  
Electrophoretic Mobility ◽  
Fluorescent Material ◽  
Creatine Kinase Bb ◽  
Natural Fluorescence

Abstract We assessed the reported presence of creatine kinase-BB isoenzyme in the serum of patients with chronic renal failure. Our study showed that the blood of these patients contains a fluorescent material with an electrophoretic mobility similar to that of the BB isoenzyme on cellulose acetate strips. The fluorescing material is, however, completely distinct from BB isoenzyme and its nature is as yet undetermined.

Colchicine-Induced Rhabdomyolysis

2002 ◽  
Vol 36 (5) ◽  
pp. 824-826 ◽  
Author(s):  
Kellie H Boomershine
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Chronic Renal Failure ◽  
Liver Function ◽  
Case Reports ◽  
Liver Function Tests ◽  
Causative Factor ◽  
Function Tests ◽  
Elevated Liver Function Tests ◽  
New Skin

OBJECTIVE: To report a case of rhabdomyolysis occurring during treatment with colchicine. CASE SUMMARY: A 44-year-old African American man was admitted to the hospital due to persistent diarrhea, vomiting, and diffuse weakness. Past medical history was significant for renal failure requiring peritoneal dialysis, gout, and a new skin lesion. Approximately 2 months prior to admission, he had been started on colchicine and allopurinol. Creatine kinase concentration on admission was >14 000 U/L. Liver function tests were elevated 5 × the upper limit of normal. Colchicine was discontinued on admission. Creatine kinase concentrations decreased significantly, and strength and ambulation improved throughout hospitalization. DISCUSSION: Colchicine was thought to be the causative factor for rhabdomyolysis in conjunction with chronic renal failure and elevated liver function tests. After discontinuation of colchicine, creatinine kinase concentrations declined and the patient's ability to walk improved. Limited case reports of colchicine-induced rhabdomyolysis have been published. CONCLUSIONS: Chronic renal failure in conjunction with elevated liver function tests appear to increase the possibility of colchicine-induced toxicity, specifically, rhabdomyolysis.

scholarly journals The presence of pamidronate in bone cement affects serum biochemical markers in the rat

2014 ◽  
Vol 58 (2) ◽  
pp. 295-299
Author(s):  
Łukasz Matuszewski ◽  
Anna Matuszewska ◽  
Magdalena Jaszek ◽  
Dawid Stefaniuk ◽  
Krzysztof Grzywnowicz ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Muscle Regeneration ◽  
Biochemical Markers ◽  
Wistar Rats ◽  
Positive Influence ◽  
Control Group ◽  
Control Groups ◽  
Male Wistar Rats ◽  
Serum Biochemical ◽  
Positive Effect

Abstract The main aim of the study was to assess whether the presence of biphosphate pamidronate (PA) in the cement implanted into the tibial bones had any effect on the chosen biochemical markers in rat’s serum characterising homeostasis. Forty adult male Wistar rats were divided into two control groups and two experimental groups. Tibial bone of rats in the experimental groups was implanted with PA-enriched cement, whereas the bone in control-group’s rats was implanted with cement without PA. Serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatine kinase (CK) were determined three and six weeks after the surgery. Statistically significant differences in the activities of AST and CK of the rats after implantation with non-enriched cement when compared to rats given PA-enriched cement implantation, were found. Six weeks after treatment, AST levels decreased significantly in rats with PA-enriched cement, whereas rats in the control group (implanted with non-enriched cement) demonstrated a significant increase in AST activity in comparison to the same values determined after three weeks and values of PA-enriched cement rats determined after six weeks. The activities of CK were higher in rats with PA-enriched implants than in the control group three weeks after surgery, but six weeks after the treatment, rats implanted with enriched cement reached lower values than animals implanted with non-enriched cement. The use of PA in the cement had also some positive effect on the homeostasis of the rats after the surgery and a positive influence on the post operative muscle regeneration process.

scholarly journals Chronic renal failure patient with membranous nephropathy on CAPD presenting with macro creatine kinase type 1.

1998 ◽  
Vol 31 (7) ◽  
pp. 1099-1105
Author(s):  
Hiroshi Kikuchi ◽  
Kouhei Ise ◽  
Seiji Fukuda ◽  
Hiroyuki Hokamaki ◽  
Tatsukuni Namihira
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Chronic Renal Failure ◽  
Membranous Nephropathy ◽  
Chronic Renal Failure Patient ◽  
Renal Failure Patient

Co-Trimoxazole in Chronic Renal Failure–A Controlled Experiment in Wistar Rats

1977 ◽  
Vol 10 (4) ◽  
pp. 411-415 ◽  
Author(s):  
M. F. ROBINSON ◽  
G. R. CAMPBELL ◽  
P. W. CRASWELL
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Wistar Rats ◽  
Controlled Experiment

scholarly journals Quercetin Attenuates Vascular Calcification through Suppressed Oxidative Stress in Adenine-Induced Chronic Renal Failure Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Xue-ying Chang ◽  
Lei Cui ◽  
Xing-zhi Wang ◽  
Lei Zhang ◽  
Dan Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Vascular Calcification ◽  
Normal Diet ◽  
Mitogen Activated Protein Kinase ◽  
Oxidative Stress Biomarkers ◽  
Sod Activity ◽  
Male Wistar Rats ◽  
P38mapk Pathway

Background.This study investigated whether quercetin could alleviate vascular calcification in experimental chronic renal failure rats induced by adenine.Methods.32 adult male Wistar rats were randomly divided into 4 groups fed normal diet, normal diet with quercetin supplementation (25 mg/kg·BW/d), 0.75% adenine diet, or adenine diet with quercetin supplementation. All rats were sacrificed after 6 weeks of intervention. Serum renal functions biomarkers and oxidative stress biomarkers were measured and status of vascular calcification in aorta was assessed. Furthermore, the induced nitric oxide synthase (iNOS)/p38 mitogen activated protein kinase (p38MAPK) pathway was determined to explore the potential mechanism.Results.Adenine successfully induced renal failure and vascular calcification in rat model. Quercetin supplementation reversed unfavorable changes of phosphorous, uric acid (UA) and creatinine levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity in serum and the increases of calcium and alkaline phosphatase (ALP) activity in the aorta (P<0.05) and attenuated calcification and calcium accumulation in the medial layer of vasculature in histopathology. Western blot analysis showed that iNOS/p38MAPK pathway was normalized by the quercetin supplementation.Conclusions.Quercetin exerted a protective effect on vascular calcification in adenine-induced chronic renal failure rats, possibly through the modulation of oxidative stress and iNOs/p38MAPK pathway.

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