Colchicine-Induced Rhabdomyolysis

2002 ◽  
Vol 36 (5) ◽  
pp. 824-826 ◽  
Author(s):  
Kellie H Boomershine
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Chronic Renal Failure ◽  
Liver Function ◽  
Case Reports ◽  
Liver Function Tests ◽  
Causative Factor ◽  
Function Tests ◽  
Elevated Liver Function Tests ◽  
New Skin

OBJECTIVE: To report a case of rhabdomyolysis occurring during treatment with colchicine. CASE SUMMARY: A 44-year-old African American man was admitted to the hospital due to persistent diarrhea, vomiting, and diffuse weakness. Past medical history was significant for renal failure requiring peritoneal dialysis, gout, and a new skin lesion. Approximately 2 months prior to admission, he had been started on colchicine and allopurinol. Creatine kinase concentration on admission was >14 000 U/L. Liver function tests were elevated 5 × the upper limit of normal. Colchicine was discontinued on admission. Creatine kinase concentrations decreased significantly, and strength and ambulation improved throughout hospitalization. DISCUSSION: Colchicine was thought to be the causative factor for rhabdomyolysis in conjunction with chronic renal failure and elevated liver function tests. After discontinuation of colchicine, creatinine kinase concentrations declined and the patient's ability to walk improved. Limited case reports of colchicine-induced rhabdomyolysis have been published. CONCLUSIONS: Chronic renal failure in conjunction with elevated liver function tests appear to increase the possibility of colchicine-induced toxicity, specifically, rhabdomyolysis.

Case 4.25

2014 ◽  
pp. 234-235
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Pancreatic Duct ◽  
Liver Function Tests ◽  
Filling Defect ◽  
Distal Common Bile Duct ◽  
Biliary Dilatation ◽  
Function Tests ◽  
Elevated Liver Function Tests

64-year-old man with elevated liver function tests MIP image from 3D FRFSE MRCP (Figure 4.25.1) reveals a filling defect in the distal common bile duct, diffuse intrahepatic biliary dilatation, and mild dilatation of the pancreatic duct. Coronal oblique SSFSE images (Figure ...

Case 3.7

2014 ◽  
pp. 146-146
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Liver Function ◽  
Equilibrium Phase ◽  
Liver Function Tests ◽  
Quadrant Pain ◽  
Function Tests ◽  
Elevated Liver Function Tests ◽  
The Right

80-year-old man with right upper quadrant pain and elevated liver function tests; abdominal US performed at an outside institution showed a mass in the gallbladder Arterial (Figure 3.7.1), portal venous (Figure 3.7.2), and equilibrium phase (Figure 3.7.3) postgadolinium 3D SPGR images demonstrate a hyperenhancing mass within the gallbladder lumen. Note also the large heterogeneous mass seen in the upper pole of the right kidney....

scholarly journals Incidence and clinical significance of elevated liver function tests in cystic fibrosis clinical trials

2013 ◽  
Vol 34 (2) ◽  
pp. 232-238 ◽  
Author(s):  
Nicole Mayer-Hamblett ◽  
Margaret Kloster ◽  
Bonnie W. Ramsey ◽  
Michael R. Narkewicz ◽  
Lisa Saiman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Clinical Trials ◽  
Liver Function ◽  
Clinical Significance ◽  
Liver Function Tests ◽  
Function Tests ◽  
Elevated Liver Function Tests

scholarly journals Primary biliary cirrhosis and hepatic sarcoidosis: A case report

2014 ◽  
Vol 71 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Tamara Alempijevic ◽  
Aleksandra Sokic-Milutinovic ◽  
Ljubisa Toncev ◽  
Aleksandra Pavlovic-Markovic ◽  
Srdjan Djuranovic ◽  
...  
Keyword(s):  
Case Report ◽  
Primary Biliary Cirrhosis ◽  
Liver Function ◽  
Elevated Serum ◽  
Liver Function Tests ◽  
Unknown Etiology ◽  
Biliary Cirrhosis ◽  
Laboratory Findings ◽  
Function Tests ◽  
Elevated Liver Function Tests

Introduction. Primary biliary cirrhosis (PBC) is an immunemediated chronic progressive inflammatory liver disease leading to destruction of small interlobular bile ducts. Sarcoidosis is a chronic disorder of unknown etiology characterized by non-caseous granulomas. Case report. We reported a 69-year-old female patient with abdominal pain, malaise, vertigo, headaches, hands tremor and partial loss of hearing. Initial laboratory findings revealed elevated liver function tests and cholesterol with positive antimytochondrial and antinuclear antibodies. Liver biopsy revealed granuloma typical for PBC and granulomatous lesions typical for sarcoidosis. Elevated serum angiotensin-converting enzyme and granulomatous lesion on the brain magnetic resonance imaging (MRI) were detected and the patient was diagnosed with overlap of PBC and liver sarcoidosis and neurosarcoidosis. The patient was treated with ursodeoxicholic acid (UDCA) and prednisolone. Six months later the patient was symptom-free with laboratory findings within normal range. Conclusion. In PBC patients it is important to consider coexisting granulomatous liver diseases if elevated liver function tests persist despite UDCA therapy.

Sign in / Sign up

Export Citation Format

Share Document