scholarly journals Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus

RNA Biology ◽  
2012 ◽  
Vol 9 (10) ◽  
pp. 1266-1274 ◽  
Author(s):  
Andrey Chursov ◽  
Sebastian J. Kopetzky ◽  
Ignaty Leshchiner ◽  
Ivan Kondofersky ◽  
Fabian J. Theis ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Temperature Sensitive ◽  
Cold Adapted ◽  
Specific Temperature ◽  
Temperature Sensitive Phenotype

ESCAPE OF A HIGHLY DEFECTIVE INFLUENZA A VIRUS MUTANT FROM ITS TEMPERATURE SENSITIVE PHENOTYPE BY EXTRAGENIC SUPPRESSION AND OTHER TYPES OF MUTATION

1980 ◽  
Vol 354 (1 Genetic Varia) ◽  
pp. 172-182 ◽  
Author(s):  
Brian R. Murphy ◽  
Mark D. Tolpin ◽  
Judith G. Massicot ◽  
Hyun Y. Kim ◽  
Robert H. Parrott ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Temperature Sensitive ◽  
Virus Mutant ◽  
Extragenic Suppression ◽  
Temperature Sensitive Phenotype

scholarly journals Molecular mechanisms of reversion to the ts+ (non-temperature-sensitive) phenotype of influenza A cold-adapted (ca) virus strains

2007 ◽  
Vol 88 (10) ◽  
pp. 2724-2729 ◽  
Author(s):  
T. M. Tsfasman ◽  
S. G. Markushin ◽  
I. I. Akopova ◽  
Y. Z. Ghendon
Keyword(s):  
Influenza A ◽  
Molecular Mechanisms ◽  
Direct Sequencing ◽  
Temperature Sensitive ◽  
Sequencing Data ◽  
Cold Adapted ◽  
Phenotypic Manifestation ◽  
Genes Encoding ◽  
Virus Strains ◽  
Temperature Sensitive Phenotype

A ts+ ca− (non-temperature-sensitive, non-cold-adapted) revertant of the A/Leningrad/134/47/57 ca strain influenza virus [A/Leningrad/134/47/ts+18/1957(H2N2)], obtained in our previous study, lost phenotypic manifestation of ts mutations by the PB2, NP and NS genes, although, according to sequencing data, it acquired only two true reversions of a mutation in the PB2 and PB1 genes. Direct sequencing showed the appearance of 27 additional mutations (13 coding) in the genes encoding the PB2, PB1, PA, NP, M and NS proteins of the revertant, along with the above-mentioned two true reversions. We conjecture that some of these mutations suppressed phenotypic manifestation of ts mutations in the NS and NP genes.

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