scholarly journals Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer

2012 ◽  
Vol 1 (8) ◽  
pp. 1420-1421 ◽  
Author(s):  
Harri Sihto ◽  
Heikki Joensuu
Author(s):  
Anish A. Butala ◽  
Varsha Jain ◽  
Vishruth K. Reddy ◽  
Ronnie A. Sebro ◽  
Yun Song ◽  
...  

2016 ◽  
Vol 8 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Hitoshi Terui ◽  
Taku Fujimura ◽  
Aya Kakizaki ◽  
Sadanori Furudate ◽  
Setsuya Aiba

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8+ cells and granulysin-bearing cells and lower numbers of CD206+ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.


1994 ◽  
Vol 56 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Fumiyoshi ASHIZUKA ◽  
Ryoji HIROSE ◽  
Kazuhiro SHIMIZU ◽  
Yoichi TANAKA ◽  
Fumi TORIYAMA

2017 ◽  
Vol 79 (6) ◽  
pp. 574-577
Author(s):  
Naomi YONEKURA ◽  
Kotaro NAGASE ◽  
Shizuka OGAWA ◽  
Hiromi KIMURA ◽  
Takuya INOUE ◽  
...  

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