scholarly journals Merkel Cell Carcinoma with Spontaneous Regression: A Case Report and Immunohistochemical Study

2016 ◽  
Vol 8 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Hitoshi Terui ◽  
Taku Fujimura ◽  
Aya Kakizaki ◽  
Sadanori Furudate ◽  
Setsuya Aiba
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immunohistochemical Staining ◽  
Spontaneous Regression ◽  
Immunohistochemical Study ◽  
Tumor Infiltrating Lymphocytes ◽  
Merkel Cell ◽  
Cd8 Cells ◽  
Immunological Mechanisms ◽  
Infiltrating Lymphocytes

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma that only rarely regresses spontaneously. Since little is known about the immunological mechanisms involved in the spontaneous regression of MCC, we describe a case of MCC with spontaneous regression and employed immunohistochemical staining for cytotoxic and immunosuppressive molecules to investigate possible mechanisms involved in the spontaneous regression of MCC. Interestingly, compared to conventional MCC, tumor-infiltrating lymphocytes in MCC with spontaneous regression contained higher numbers of CD8+ cells and granulysin-bearing cells and lower numbers of CD206+ cells. Our present study suggests one of the possible reasons for the spontaneous regression of MCC.

scholarly journals Impact of Tumor-Infiltrating Lymphocytes on Overall Survival in Merkel Cell Carcinoma

2020 ◽  
Author(s):  
Anish A. Butala ◽  
Varsha Jain ◽  
Vishruth K. Reddy ◽  
Ronnie A. Sebro ◽  
Yun Song ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Tumor Infiltrating Lymphocytes ◽  
Merkel Cell ◽  
Infiltrating Lymphocytes

scholarly journals Merkel Cell Carcinoma Concomitant with Invasive Bowen's Disease: Immunohistochemical Investigation of Tumor-Infiltrating Leukocytes

2015 ◽  
Vol 7 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Hisayuki Tono ◽  
Taku Fujimura ◽  
Eimei Iwama ◽  
Yoshiyuki Kusakari ◽  
Sadanori Furudate ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Caspase 3 ◽  
Immunohistochemical Study ◽  
Good Prognosis ◽  
Merkel Cell ◽  
Bowen’S Disease ◽  
Cd8 Cells ◽  
Bowen's Disease ◽  
Cutaneous Neuroendocrine Carcinoma

Merkel cell carcinoma (MCC) is an aggressive, cutaneous, neuroendocrine carcinoma and, in rare cases, occurs with Bowen's disease (BD). In this report, we describe a case of MCC concurrent with invasive BD and compare the profiles of tumor-infiltrating leukocytes in the lesional skin of MCC and invasive BD. Interestingly, immunohistochemical study revealed significant numbers of CD8+ cells and caspase 3-expressing cells in the same areas of invasive BD and MCC. Our present case suggests that MCC concurrent with invasive BD might have a good prognosis because of the substantial number of CD8+ cells in the tumor.

Complete spontaneous regression of primary Merkel cell carcinoma with tumoural infiltration: a systematic review

2021 ◽  
Vol 31 (3) ◽  
pp. 381-391
Author(s):  
Laurie Ah-Thiane ◽  
Mahtab Samimi ◽  
Thibault Kervarrec ◽  
Amir Khammari ◽  
Brigitte Dréno
Keyword(s):  
Systematic Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Spontaneous Regression ◽  
Merkel Cell

scholarly journals Spontaneous regression of Merkel cell carcinoma in a patient with chronic lymphocytic leukemia: a case report

2009 ◽  
Vol 3 (1) ◽  
Author(s):  
Tamara Turk ◽  
Zeljka Crncevic Orlic ◽  
Ivana Smoljan ◽  
Antica Nacinovic ◽  
Irena Seili Bekafigo ◽  
...  
Keyword(s):  
Case Report ◽  
Chronic Lymphocytic Leukemia ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Spontaneous Regression ◽  
Lymphocytic Leukemia ◽  
Merkel Cell

scholarly journals Case for diagnosis

2012 ◽  
Vol 87 (3) ◽  
pp. 491-492 ◽  
Author(s):  
Bernardo Gontijo ◽  
Thaíssa Oliveira de Almeida Coelho ◽  
Flávia Vasques Bittencourt ◽  
Glaysson Tassara Tavares ◽  
Angélica Duarte Oliveira Rocha
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Male Patient ◽  
Immunohistochemical Staining ◽  
Left Cheek ◽  
Merkel Cell ◽  
Caucasian Male ◽  
Deep Dermis

An 80-year-old Caucasian male patient was referred for evaluation of a rapidly growing, asymptomatic, erythematous nodule measuring 2 cm in diameter on his left cheek. The lesion had been present for four months. Dermoscopy revealed a homogeneous pink background with polymorphous telangiectatic vessels. Histopathology showed tumors in the deep dermis and subcutis composed of round cells with scant cytoplasm. Immunohistochemical staining was positive for CK20 confirming the diagnosis of Merkel cell carcinoma.

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