scholarly journals Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry

mAbs ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 114-125 ◽  
Author(s):  
Liangjie Tang ◽  
Shanmuuga Sundaram ◽  
Jingming Zhang ◽  
Ping Carlson ◽  
Alice Matathia ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Exchange Mass Spectrometry ◽  
Igg1 Monoclonal Antibody ◽  
Human Igg1 ◽  
Charge Variants ◽  
Human Igg1 Monoclonal Antibody

Characterization of Human IgG1 Monoclonal Antibody Against Gangliosides Expressed on Tumor Cells

Hybridoma ◽  
1998 ◽  
Vol 17 (2) ◽  
pp. 133-142 ◽  
Author(s):  
SONJOY MUKERJEE ◽  
MARC NASOFF ◽  
MICHAEL McKNIGHT ◽  
MARK GLASSY
Keyword(s):  
Monoclonal Antibody ◽  
Tumor Cells ◽  
Igg1 Monoclonal Antibody ◽  
Human Igg1 ◽  
Human Igg1 Monoclonal Antibody

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

IMC-A12, a Human IgG1 Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor: Fig. 1.

2007 ◽  
Vol 13 (18) ◽  
pp. 5549s-5555s ◽  
Author(s):  
Eric K. Rowinsky ◽  
Hagop Youssoufian ◽  
James R. Tonra ◽  
Phillip Solomon ◽  
Douglas Burtrum ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igg1 Monoclonal Antibody ◽  
Human Igg1 ◽  
Growth Factor I ◽  
Human Igg1 Monoclonal Antibody

scholarly journals Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

mAbs ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 941-950 ◽  
Author(s):  
James C. Geoghegan ◽  
Ryan Fleming ◽  
Melissa Damschroder ◽  
Steven M. Bishop ◽  
Hasige A. Sathish ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Rational Structure ◽  
Igg1 Monoclonal Antibody ◽  
Human Igg1 ◽  
Self Association ◽  
Human Igg1 Monoclonal Antibody
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