scholarly journals Expression of secretory phospholipase A2in insulitis of human transplanted pancreas and its insulinotropic effect on isolated rat islets

Islets ◽  
2010 ◽  
Vol 2 (5) ◽  
pp. 274-277 ◽  
Author(s):  
Miwako Ishida-Oku ◽  
Masanori Iwase ◽  
Kazuo Sonoki ◽  
Nobuhiro Sasaki ◽  
Hirofumi Imoto ◽  
...  
Keyword(s):  
Secretory Phospholipase ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Insulinotropic Effect ◽  
Isolated Rat

Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets

1975 ◽  
Vol 228 (6) ◽  
pp. 1669-1677 ◽  
Author(s):  
JC Henquin ◽  
AE Lambert
Keyword(s):  
Calcium Influx ◽  
Islet Cells ◽  
Inhibitory Effect ◽  
Immunoreactive Insulin ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Insulinotropic Effect ◽  
Effect Of Glucose ◽  
Dose Dependent ◽  
Isolated Rat

Cobalt (Co'++) inhibited glucose-, leucine-, and K'+-induced immunoreactive insulin (IRI)release by isolated rat islets. This inhibition of the insulinotropic effect of glucose was dose dependent, affected both phases of secretion, was very rapid, and was well reversible. It exhibited a kinetics similiar to that of Ca'++ omission, and the metal (2.5 mM) prevented Ca'++ reintroduction from restoring a normal rate of IRI release. Theophylline (2 mM) partially overcame the inhibitory effect of 0.5 mM Co'++, but not that of 2.5 mM. Glucose-induced secretion was lessmarkedly reduced by 0.5 mM Co'++ in the absence of Mg'++ or in the presence of 7.5 mM Ca'++. Even at 12.5 mM, the metal did not alter glucose oxidation by theislets. By contrast, Ca uptake by islet cells was reversibly diminished (55%) in the presence of 1.25 mM Co'++. Calcium influx (measured after 2.5 min) was aslo reduced by Co'++ to a degree that did not change after longer incubation periods. It is concluded that Co'++ inhibits IRI release mainly through an antaognistic action on Ca entry in beta cells.

Effects of monensin on conversion of proinsulin to insulin and secretion of newly synthesized insulin in isolated rat islets

Diabetes ◽  
1984 ◽  
Vol 33 (11) ◽  
pp. 1019-1024 ◽  
Author(s):  
G. Gold ◽  
J. Pou ◽  
R. M. Nowlain ◽  
G. M. Grodsky
Keyword(s):  
Rat Islets ◽  
Isolated Rat Islets ◽  
Isolated Rat

Stimulation of insulin secretion from isolated rat islets by SaRI 59-801

Diabetes ◽  
1985 ◽  
Vol 34 (6) ◽  
pp. 548-552 ◽  
Author(s):  
R. L. Hanson ◽  
C. M. Isaacson ◽  
L. D. Boyajy
Keyword(s):  
Insulin Secretion ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Isolated Rat ◽  
Stimulation Of

Cryogenic preservation of isolated rat islets of Langerhans

Cryobiology ◽  
1976 ◽  
Vol 13 (6) ◽  
pp. 646-647
Author(s):  
Harvey Bank ◽  
Richard Davis ◽  
James Scoggin ◽  
Richard Weiss ◽  
Dorothy Noe
Keyword(s):  
Islets Of Langerhans ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Rat Islets Of Langerhans ◽  
Isolated Rat

scholarly journals Effect of age on glucose oxidation by isolated rat islets

Diabetologia ◽  
1980 ◽  
Vol 18 (1) ◽  
pp. 69-71 ◽  
Author(s):  
G. M. Reaven ◽  
P. D. Reaven
Keyword(s):  
Glucose Oxidation ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Effect Of Age ◽  
Isolated Rat

scholarly journals Evaluation of Insulin Secretion of Isolated Rat Islets Cultured in Extracellular Matrix

2001 ◽  
Vol 10 (4-5) ◽  
pp. 447-451 ◽  
Author(s):  
Natsuki Nagata ◽  
Yuanjun Gu ◽  
Hiroshi Hori ◽  
A. N. Balamurugan ◽  
Maki Touma ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Insulin Secretion ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Isolated Rat

scholarly journals Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets

2006 ◽  
Vol 119 (7) ◽  
pp. 574-580 ◽  
Author(s):  
Jing-yan TIAN ◽  
Guo LI ◽  
Yan-yun GU ◽  
Hong-li ZHANG ◽  
Wen-zhong ZHOU ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Secretion ◽  
Free Fatty Acids ◽  
Rat Islets ◽  
Isolated Rat Islets ◽  
Isolated Rat
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