scholarly journals Pancreatic cancer: Role of the immune system in cancer progression and vaccine-based immunotherapy

2014 ◽  
Vol 10 (11) ◽  
pp. 3354-3368 ◽  
Author(s):  
Amedeo Amedei ◽  
Elena Niccolai ◽  
Domenico Prisco
Keyword(s):  
Pancreatic Cancer ◽  
Immune System ◽  
Cancer Progression

Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies

2014 ◽  
Vol 40 (4) ◽  
pp. 513-522 ◽  
Author(s):  
K. Sideras ◽  
H. Braat ◽  
J. Kwekkeboom ◽  
C.H. van Eijck ◽  
M.P. Peppelenbosch ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune System ◽  
Cancer Progression ◽  
Treatment Strategies

scholarly journals Abstract 2679: Role of TH2 cells in pancreatic cancer progression

2021 ◽  
Author(s):  
Aftab Alam ◽  
Maulasri Bhatta ◽  
Parker Denz ◽  
Eric Levanduski ◽  
Prasenjit Dey
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Th2 Cells

scholarly journals PO-083 The role of the humoral immune system in pancreatic cancer

2018 ◽  
Author(s):  
S Sollie ◽  
D Michaud ◽  
D Sarker ◽  
S Karagiannis ◽  
D Josephs ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune System ◽  
Humoral Immune ◽  
Humoral Immune System

scholarly journals Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Chiara Bazzichetto ◽  
Fabiana Conciatori ◽  
Italia Falcone ◽  
Francesco Cognetti ◽  
Michele Milella ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Progression ◽  
Cancer Progression ◽  
Epidemiological Data ◽  
Tumor Stroma ◽  
Cytokine Network ◽  
Pharmacological Response ◽  
Wide Range ◽  
Clinical Models

Cytokines are a family of soluble factors (Growth Factors (GFs), chemokines, angiogenic factors, and interferons), which regulate a wide range of mechanisms in both physiological and pathological conditions, such as tumor cell growth and progression, angiogenesis, and metastasis. In recent years, the growing interest in developing new cancer targeted therapies has been accompanied by the effort to characterize Tumor Microenvironment (TME) and Tumor-Stroma Interactions (TSI). The connection between tumor and stroma is now well established and, in the last decade, evidence from genetic, pharmacological, and epidemiological data supported the importance of microenvironment in tumor progression. However, several of the mechanisms behind TSI and their implication in tumor progression remain still unclear and it is crucial to establish their potential in determining pharmacological response. Many studies have demonstrated that cytokines network can profoundly affect TME, thus displaying potential therapeutic efficacy in both preclinical and clinical models. The goal of this review is to give an overview of the most relevant cytokines involved in colorectal and pancreatic cancer progression and their implication in drug response.

The Role of Stromal Components in Pancreatic Cancer Progression

2016 ◽  
Vol 16 (9) ◽  
pp. 1117-1124 ◽  
Author(s):  
Mengdan Xu ◽  
Binhua P. Zhou ◽  
Min Tao ◽  
Jingyi Liu ◽  
Wei Li
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression

scholarly journals Pattern Recognition Receptors in Cancer Progression and Metastasis

2015 ◽  
Vol 8 ◽  
pp. CGM.S24314 ◽  
Author(s):  
Sanjay Pandey ◽  
Saurabh Singh ◽  
Vandana Anang ◽  
Anant N. Bhatt ◽  
K. Natarajan ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Immune System ◽  
Tumor Cell ◽  
Cancer Progression ◽  
Innate Immune System ◽  
Pattern Recognition Receptors ◽  
Innate Immune ◽  
Preventive Strategy ◽  
Chronic Activation

The innate immune system is an integral component of the inflammatory response to pathophysiological stimuli. Toll-like receptors (TLRs) and inflammasomes are the major sensors and pattern recognition receptors (PRRs) of the innate immune system that activate stimulus (signal)-specific proinflammatory responses. Chronic activation of PRRs has been found to be associated with the aggressiveness of various cancers and poor prognosis. Involvement of PRRs was earlier considered to be limited to infection- and injury-driven carcinogenesis, where they are activated by pathogenic ligands. With the recognition of damage-associated molecular patterns (DAMPs) as ligands of PRRs, the role of PRRs in carcinogenesis has also been implicated in other non-pathogen-driven neoplasms. Dying (apoptotic or necrotic) cells shed a plethora of DAMPs causing persistent activation of PRRs, leading to chronic inflammation and carcinogenesis. Such chronic activation of TLRs promotes tumor cell proliferation and enhances tumor cell invasion and metastasis by regulating pro-inflammatory cytokines, metalloproteinases, and integrins. Due to the decisive role of PRRs in carcinogenesis, targeting PRRs appears to be an effective cancer-preventive strategy. This review provides a brief account on the association of PRRs with various cancers and their role in carcinogenesis.

scholarly journals Elucidating the Role of Extracellular Vesicles in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5669
Author(s):  
Akbar Lulu Marzan ◽  
Sarah Elizabeth Stewart
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Survival Rate ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Current Knowledge ◽  
Treatment Options ◽  
Metabolic Dysfunction ◽  
Underlying Mechanisms

Pancreatic cancer is one of the deadliest cancers worldwide, with a 5-year survival rate of less than 10%. This dismal survival rate can be attributed to several factors including insufficient diagnostics, rapid metastasis and chemoresistance. To identify new treatment options for improved patient outcomes, it is crucial to investigate the underlying mechanisms that contribute to pancreatic cancer progression. Accumulating evidence suggests that extracellular vesicles, including exosomes and microvesicles, are critical players in pancreatic cancer progression and chemoresistance. In addition, extracellular vesicles also have the potential to serve as promising biomarkers, therapeutic targets and drug delivery tools for the treatment of pancreatic cancer. In this review, we aim to summarise the current knowledge on the role of extracellular vesicles in pancreatic cancer progression, metastasis, immunity, metabolic dysfunction and chemoresistance, and discuss their potential roles as biomarkers for early diagnosis and drug delivery vehicles for treatment of pancreatic cancer.

The role of SPARC expression in pancreatic cancer progression and patient survival

2015 ◽  
Vol 50 (9) ◽  
pp. 1170-1174 ◽  
Author(s):  
Chinmay Gundewar ◽  
Agata Sasor ◽  
Katarzyna Said Hilmersson ◽  
Roland Andersson ◽  
Daniel Ansari
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Patient Survival ◽  
Sparc Expression

scholarly journals Role of microenvironmental periostin in pancreatic cancer progression

Oncotarget ◽  
2016 ◽  
Vol 8 (52) ◽  
pp. 89552-89565 ◽  
Author(s):  
Yang Liu ◽  
Fan Li ◽  
Feng Gao ◽  
Lingxi Xing ◽  
Peng Qin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression
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