scholarly journals Infection-enhancing lipopeptides do not improve intranasal immunization of cotton rats with a delta-G candidate live-attenuated human respiratory syncytial virus vaccine

2013 ◽  
Vol 9 (12) ◽  
pp. 2578-2583 ◽  
Author(s):  
D Tien Nguyen ◽  
Jolande Boes ◽  
Geert van Amerongen ◽  
Yvonne van Remmerden ◽  
Selma Yüksel ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Vaccine ◽  
Human Respiratory Syncytial Virus ◽  
Intranasal Immunization ◽  
Cotton Rats ◽  
Syncytial Virus ◽  
Delta G ◽  
Respiratory Syncytial Virus Vaccine

Enhanced pulmonary pathology associated with the use of formalin-inactivated respiratory syncytial virus vaccine in cotton rats is not a unique viral phenomenon

Vaccine ◽  
1993 ◽  
Vol 11 (14) ◽  
pp. 1415-1423 ◽  
Author(s):  
Pedro A. Piedra ◽  
Philip R. Wyde ◽  
William L. Castleman ◽  
Mark W. Ambrose ◽  
Alan M. Jewell ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Vaccine ◽  
Cotton Rats ◽  
Pulmonary Pathology ◽  
Syncytial Virus ◽  
Respiratory Syncytial Virus Vaccine

Human respiratory syncytial virus vaccine antigen produced in plants

2000 ◽  
Vol 14 (14) ◽  
pp. 2323-2328 ◽  
Author(s):  
Helene Belanger ◽  
Nina Fleysh ◽  
Shannon Cox ◽  
Greg Hartman ◽  
Deepali Deka ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Vaccine ◽  
Human Respiratory Syncytial Virus ◽  
Vaccine Antigen ◽  
Syncytial Virus ◽  
Respiratory Syncytial Virus Vaccine

Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice

Vaccine ◽  
2019 ◽  
Vol 37 (30) ◽  
pp. 4031-4039 ◽  
Author(s):  
Abenaya Muralidharan ◽  
Marsha S. Russell ◽  
Louise Larocque ◽  
Caroline Gravel ◽  
Simon Sauvé ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Immune Responses ◽  
Virus Vaccine ◽  
Lung Histopathology ◽  
Syncytial Virus ◽  
Respiratory Syncytial Virus Vaccine

scholarly journals Progress toward a Respiratory Syncytial Virus Vaccine

2016 ◽  
Vol 23 (3) ◽  
pp. 186-188 ◽  
Author(s):  
Kathleen M. Neuzil
Keyword(s):  
Viral Load ◽  
Respiratory Syncytial Virus ◽  
Virus Vaccine ◽  
Effective Vaccine ◽  
Vaccine Candidates ◽  
Target Populations ◽  
Link Type ◽  
History Of ◽  
Syncytial Virus ◽  
Respiratory Syncytial Virus Vaccine

ABSTRACTIn accompanying papers (P. L. Acosta, M. T. Caballero, and F. P. Polack, Clin Vaccine Immunol 23:189–195, 2016,http://dx.doi.org/10.1128/CVI.00609-15; M. Vissers, I. M. L. Ahout, M. I. de Jonge, and G. Ferwerda, Clin Vaccine Immunol 23:243–245, 2016,http://dx.doi.org/10.1128/CVI.00590-15) in this issue ofClinical and Vaccine Immunology, the history of and immune mechanisms underlying vaccine-enhanced respiratory syncytial virus (RSV) disease and of investigations of mucosal antibodies and their association with viral load in RSV-infected children, respectively, are described. This commentary discusses RSV vaccine candidates, target populations, and the challenges associated with achieving a safe and effective vaccine.

scholarly journals Recombinant subtype A and B human respiratory syncytial virus clinical isolates co-infect the respiratory tract of cotton rats

2020 ◽  
Vol 101 (10) ◽  
pp. 1056-1068
Author(s):  
Linda J. Rennick ◽  
Sham Nambulli ◽  
Ken Lemon ◽  
Grace Y. Olinger ◽  
Nicholas A. Crossland ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Reverse Genetics ◽  
Fluorescent Protein ◽  
Human Respiratory Syncytial Virus ◽  
Subtype B ◽  
Cotton Rats ◽  
Syncytial Virus ◽  
Subtype A

Human respiratory syncytial virus (HRSV) is an important respiratory pathogen causing a spectrum of illness, from common cold-like symptoms, to bronchiolitis and pneumonia requiring hospitalization in infants, the immunocompromised and the elderly. HRSV exists as two antigenic subtypes, A and B, which typically cycle biannually in separate seasons. There are many unresolved questions in HRSV biology regarding the interactions and interplay of the two subtypes. Therefore, we generated a reverse genetics system for a subtype A HRSV from the 2011 season (A11) to complement our existing subtype B reverse genetics system. We obtained the sequence (HRSVA11) directly from an unpassaged clinical sample and generated the recombinant (r) HRSVA11. A version of the virus expressing enhanced green fluorescent protein (EGFP) from an additional transcription unit in the fifth (5) position of the genome, rHRSVA11EGFP(5), was also generated. rHRSVA11 and rHRSVA11EGFP(5) grew comparably in cell culture. To facilitate animal co-infection studies, we derivatized our subtype B clinical isolate using reverse genetics toexpress the red fluorescent protein (dTom)-expressing rHRSVB05dTom(5). These viruses were then used to study simultaneous in vivo co-infection of the respiratory tract. Following intranasal infection, both rHRSVA11EGFP(5) and rHRSVB05dTom(5) infected cotton rats targeting the same cell populations and demonstrating that co-infection occurs in vivo. The implications of this finding on viral evolution are important since it shows that inter-subtype cooperativity and/or competition is feasible in vivo during the natural course of the infection.

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