scholarly journals Proteome profiling reveals tissue-specific protein expression in the male reproductive system ofDrosophila melanogaster

Fly ◽  
2010 ◽  
Vol 4 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Masa-Toshi Yamamoto ◽  
Nobuaki Takemori
Keyword(s):  
Protein Expression ◽  
Reproductive System ◽  
Specific Protein ◽  
Male Reproductive System ◽  
Tissue Specific ◽  
Proteome Profiling

Proteome profiling reveals tissue-specific protein expression in male and female accessory glands of the silkworm, Bombyx mori

Amino Acids ◽  
2016 ◽  
Vol 48 (5) ◽  
pp. 1173-1183 ◽  
Author(s):  
Zhaoming Dong ◽  
Xiaohuan Wang ◽  
Yan Zhang ◽  
Liping Zhang ◽  
Quanmei Chen ◽  
...  
Keyword(s):  
Protein Expression ◽  
Bombyx Mori ◽  
Specific Protein ◽  
Male And Female ◽  
Tissue Specific ◽  
Proteome Profiling ◽  
Accessory Glands ◽  
Silkworm Bombyx Mori

Tissue-Specific Protein Expression in Plant Mitochondria

1994 ◽  
Vol 6 (1) ◽  
pp. 85 ◽  
Author(s):  
Catharine A. Conley ◽  
Maureen R. Hanson
Keyword(s):  
Protein Expression ◽  
Plant Mitochondria ◽  
Specific Protein ◽  
Tissue Specific

scholarly journals Distinct responses to rare codons in select Drosophila tissues

2022 ◽  
Author(s):  
Scott R. Allen ◽  
Rebeccah K Stewart ◽  
Michael Rogers ◽  
Ivan Jimenez Ruiz ◽  
Erez Cohen ◽  
...  
Keyword(s):  
Protein Expression ◽  
Codon Usage ◽  
Codon Usage Bias ◽  
Critical Role ◽  
Specific Protein ◽  
Human Testis ◽  
Rare Codon ◽  
Tissue Specific ◽  
Rare Codons ◽  
Drosophila Testis

Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on tissue-specific mRNA and protein expression. Here, we use codon-modified reporters to perform an organism-wide screen in Drosophila melanogaster for distinct tissue responses to codon usage bias. These reporters reveal a cliff-like decline of protein expression near the limit of rare codon usage in endogenously expressed Drosophila genes. Near the edge of this limit, however, we find the testis and brain are uniquely capable of expressing rare codon-enriched reporters. We define a new metric of tissue-specific codon usage, the tissue-apparent Codon Adaptation Index, to reveal a conserved enrichment for rare codon usage in the endogenously expressed genes of both Drosophila and human testis. We further demonstrate a role for rare codons in restricting protein expression of an evolutionarily young gene, RpL10Aa, to the Drosophila testis. Rare codon-mediated restriction of this testis-specific protein is critical for female fertility. Our work highlights distinct responses to rarely used codons in select tissues, revealing a critical role for codon bias in tissue biology.

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