scholarly journals Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate

Epigenetics ◽  
2006 ◽  
Vol 1 (2) ◽  
pp. 81-87 ◽  
Author(s):  
H.Frederik Nijhout ◽  
Michael C. Reed ◽  
David F. Anderson ◽  
Jonathan C. Mattingly ◽  
S. Jill James ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Long Range ◽  
Reaction Rate ◽  
Methylation Reaction ◽  
Allosteric Interactions

scholarly journals B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation

Leukemia ◽  
2019 ◽  
Vol 34 (4) ◽  
pp. 1158-1162 ◽  
Author(s):  
Alberto Bueno-Costa ◽  
David Piñeyro ◽  
Marta Soler ◽  
Biola M. Javierre ◽  
Helena Raurell-Vila ◽  
...  
Keyword(s):  
Dna Methylation ◽  
B Cell ◽  
Long Range ◽  
Cell Leukemia ◽  
B Cell Leukemia

scholarly journals DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner

2006 ◽  
Vol 20 (24) ◽  
pp. 3382-3394 ◽  
Author(s):  
M. Oda ◽  
A. Yamagiwa ◽  
S. Yamamoto ◽  
T. Nakayama ◽  
A. Tsumura ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Gene Silencing ◽  
Gene Cluster ◽  
Long Range ◽  
Homeobox Gene ◽  
Specific Manner

scholarly journals Formins Regulate Actin Filament Flexibility through Long Range Allosteric Interactions

2006 ◽  
Vol 281 (16) ◽  
pp. 10727-10736 ◽  
Author(s):  
Beáta Bugyi ◽  
Gábor Papp ◽  
Gábor Hild ◽  
Dénes Lôrinczy ◽  
Elisa M. Nevalainen ◽  
...  
Keyword(s):  
Long Range ◽  
Actin Filament ◽  
Allosteric Interactions

scholarly journals DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells

2016 ◽  
Author(s):  
Ling Zhang ◽  
Wen Jun Xie ◽  
Sirui Liu ◽  
Luming Meng ◽  
Chan Gu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Long Range ◽  
Power Law ◽  
Chromatin Structure ◽  
Spatial Organization ◽  
Large Set ◽  
Sequencing Data ◽  
Scaling Exponents ◽  
Cell Class ◽  
Partially Methylated

AbstractThe relation between DNA methylation and chromatin structure is still largely unknown. By analyzing a large set of sequencing data, we observed a long-range power law correlation of DNA methylation with cell-class-specific scaling exponents in the range of thousands to millions of base pairs. We showed such cell-class-specific scaling exponents are caused by different patchiness of DNA methylation in different cells. By modeling the chromatin structure using Hi-C data and mapping the methylation level onto the modeled structure, we demonstrated the patchiness of DNA methylation is related to chromatin structure. The scaling exponents of the power law correlation is thus a display of the spatial organization of chromatin. Besides, the local correlation of DNA methylation is associated with nucleosome positioning and different between partially-methylated-domain and non-partially-methylated-domain, suggesting their different chromatin structures at several nucleosomes level. Our study provides a novel view of the spatial organization of chromatin structure from a perspective of DNA methylation, in which both long-range and local correlations of DNA methylation along the genome reflect the spatial organization of chromatin.

scholarly journals Long-range control of gene expression via RNA-directed DNA methylation

PLoS Genetics ◽  
2017 ◽  
Vol 13 (5) ◽  
pp. e1006749 ◽  
Author(s):  
M. Jordan Rowley ◽  
M. Hafiz Rothi ◽  
Gudrun Böhmdorfer ◽  
Jan Kuciński ◽  
Andrzej T. Wierzbicki
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Long Range ◽  
Control Of Gene Expression
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