scholarly journals Exon 11 skipping ofSCN10Acoding for voltage-gated sodium channels in dorsal root ganglia

Channels ◽  
2014 ◽  
Vol 8 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Jana Schirmeyer ◽  
Karol Szafranski ◽  
Enrico Leipold ◽  
Christian Mawrin ◽  
Matthias Platzer ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Exon 11

Carvacrol modulates voltage-gated sodium channels kinetics in dorsal root ganglia

2015 ◽  
Vol 756 ◽  
pp. 22-29 ◽  
Author(s):  
Humberto Cavalcante Joca ◽  
Daiana Cardoso Oliveira Vieira ◽  
Aliny Perreira Vasconcelos ◽  
Demetrius Antônio Machado Araújo ◽  
Jader Santos Cruz
Keyword(s):  
Sodium Channels ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

scholarly journals Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Chun-Ping Huang ◽  
Hsiang-Ni Chen ◽  
Hong-Lin Su ◽  
Ching-Liang Hsieh ◽  
Wei-Hsin Chen ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Dorsal Root Ganglia ◽  
Inflammatory Pain ◽  
Dorsal Root ◽  
Low Frequency ◽  
Thermal Hyperalgesia ◽  
Nerve Fibers ◽  
Drg Neurons ◽  
Plantar Surface ◽  
Voltage Gated Sodium Channels

Several voltage-gated sodium channels (Navs) from nociceptive nerve fibers have been identified as important effectors in pain signaling. The objective of this study is to investigate the electroacupuncture (EA) analgesia mechanism by changing the expression of Navs in mice dorsal root ganglia (DRG). We injected carrageenan and complete Freund's adjuvant (CFA) into the mice plantar surface of the hind paw to induce inflammation and examined the antinociception effect of EA at the Zusanli (ST36) acupoint at 2 Hz low frequency. Mechanical hyperalgesia was evaluated by using electronic von Frey filaments, and thermal hyperalgesia was assessed using Hargreaves' test. Furthermore, we observed the expression and quality of Navs in DRG neurons. Our results showed that EA reduced mechanical and thermal pain in inflammatory animal model. The expression of Nav1.7 and Nav1.8 was increased after 4 days of carrageenan- and CFA-elicited inflammatory pain and further attenuated by 2 Hz EA stimulation. The attenuation cannot be observed in Nav1.9 sodium channels. We demonstrated that EA at Zusanli (ST36) acupoint at 2 Hz low-frequency stimulation attenuated inflammatory pain accompanied by decreasing the expression of Nav1.7 and 1.8, rather than Nav1.9, sodium channels in peripheral DRG neurons.

scholarly journals Caffeine Consumption Influences Lidocaine Action via Pain-Related Voltage-Gated Sodium Channels: An In Vivo Animal Study

2022 ◽  
Vol 2022 ◽  
pp. 1-8
Author(s):  
Reham Alfaraj ◽  
Zainab Alabdulsalam ◽  
Zahrah Alfaraj ◽  
Hawraa Alsunni ◽  
Hussain Alhawaj ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Dorsal Root ◽  
Caffeine Intake ◽  
Control Group ◽  
Intraplantar Injection ◽  
Caffeine Consumption ◽  
Voltage Gated ◽  
Thermal Pain ◽  
Voltage Gated Sodium Channels ◽  
Pressure Sensation

Several factors might influence the duration and efficiency of local anesthesia. This study investigates the effect of habitual caffeine intake on lidocaine action and explores the potential involvement of voltage-gated sodium channels in the interaction effect. Wistar rats were divided into four groups: (i) control (Ctrl), (ii) lidocaine intraplantar injection (LIDO), (iii) habitual caffeine intake (CAF), and (iv) lidocaine intraplantar injection and habitual caffeine intake (LIDO + CAF). Behavioral assessments, consisting of a paw pressure test for mechanical pressure sensation and a paw withdrawal latency test for thermal pain sensation, were performed at 0, 30, 60, and 90 minutes following lidocaine injection and after 10, 11, and 12 weeks of CAF intake. Pressure sensation was significantly reduced in the LIDO + CAF group compared with the control group. Moreover, the LIDO + CAF group exhibited reduced sensation compared to LIDO alone group. The LIDO + CAF combination exerted a synergistic effect at 30 and 60 minutes compared with the control. This synergistic effect was noted at 60 minutes (11 weeks of CAF intake) and at 30 minutes (12 weeks of CAF intake) compared with LIDO alone. Augmented thermal pain-relieving effects were observed in the LIDO + CAF group at all weeks compared to the control group and at 10 weeks compared to LIDO alone group. The molecular analysis of dorsal root ganglia suggested that CAF upregulated the mRNA expression of the Nav1.3, Nav1.7, and Nav1.8 sodium channel subtypes. Chronic caffeine consumption potentiates the local anesthetic action of lidocaine in an experimental animal model through mechanisms that involve the upregulation of voltage-gated sodium channels in the dorsal root ganglia.

Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons

2013 ◽  
Vol 247 ◽  
pp. 466-475 ◽  
Author(s):  
Kai-Feng Shen ◽  
He-Quan Zhu ◽  
Xu-Hong Wei ◽  
Jun Wang ◽  
Yong-Yong Li ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Sodium Channels ◽  
Dorsal Root ◽  
Interleukin 10 ◽  
Dorsal Root Ganglion Neurons ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Ganglion Neurons
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