scholarly journals Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

Cell Cycle ◽  
2009 ◽  
Vol 8 (6) ◽  
pp. 909-915 ◽  
Author(s):  
Irina N. Alimova ◽  
Bolin Liu ◽  
Zeying Fan ◽  
Susan M. Edgerton ◽  
Thomas Dillon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Breast Cancer Cell ◽  
Colony Formation ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis

2017 ◽  
Vol 39 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
Chen Wang ◽  
Chenlu Liang ◽  
Weiliang Feng ◽  
Xianghou Xia ◽  
Feng Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals BTG1 inhibits breast cancer cell growth through induction of cell cycle arrest and apoptosis

2013 ◽  
Vol 30 (5) ◽  
pp. 2137-2144 ◽  
Author(s):  
RAN ZHU ◽  
SHI-TAO ZOU ◽  
JIAN-MEI WAN ◽  
WEI LI ◽  
XIN-LI LI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals MicroRNA-203 Regulates Growth and Metastasis of Breast Cancer

2015 ◽  
Vol 37 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shan Zhao ◽  
Jinzhu Han ◽  
Likang Zheng ◽  
Zixin Yang ◽  
Li Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

Backgrounds/Aims: MicroRNAs (MiRNAs) control many biological events and play critical roles in the development of tumor. Among all miRNAs, miR203 has been recently shown to have an inhibitory effect on prostate cancer. However, its involvement in the carcinogenesis of breast cancer has not been reported. Methods: We examined the levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. We also examined the levels of miR203 in several commonly used breast cancer cell lines. The effects of overexpression or depletion of miR203 on breast cancer cell growth were analyzed by a MTT assay, and on breast cancer cell invasion were examined by a scratch wound healing assay and a transwell cell migration assay. MiR203-targeted genes were analyzed by Western blot. Results: We detected significantly lower levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. Moreover, the levels of miR203 were significantly lower in breast cancer tissue from the patients with cancer metastasis. Decreased miR203 levels were detected in all examined breast cancer lines. Overexpression of miR203 inhibited breast cancer cell growth and invasion, while antisense-mediated inhibition of miR203 enhanced cancer cell growth and invasion. Further analyses show that miR203 may inhibit cell growth through decreasing cell-cycle activator cyclinD2 and CDK6, increasing cell-cycle suppressor p21 and p27, and increasing apoptosis-associated protein Bcl-2. MiR203 may also inhibit cell metastasis through suppressing matrix metalloproteinase 2 (MMP2), MMP7 and MMP9. Conclusion: Our data thus highlight miR203 as a novel therapeutic target for breast cancer.

Fucoidan Inhibited 4T1 Mouse Breast Cancer Cell Growth In Vivo and In Vitro Via Downregulation of Wnt/β-Catenin Signaling

2013 ◽  
Vol 65 (3) ◽  
pp. 460-468 ◽  
Author(s):  
Meilan Xue ◽  
Yinlin Ge ◽  
Jinyu Zhang ◽  
Yongchao Liu ◽  
Qing Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Mouse Breast Cancer

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

2009 ◽  
Vol 120 (1) ◽  
pp. 253-260 ◽  
Author(s):  
Ramon C. Sun ◽  
Mitali Fadia ◽  
Jane E. Dahlstrom ◽  
Christopher R. Parish ◽  
Philip G. Board ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Metastatic Breast ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Human serum albumin-mediated apoptin delivery suppresses breast cancer cell growth in vitro and in vivo

2016 ◽  
Vol 13 (2) ◽  
pp. 579-586 ◽  
Author(s):  
Fang Wu ◽  
Yizhi Liu ◽  
Jian Li ◽  
Lei Hou ◽  
Fuxi Lei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors

Oncotarget ◽  
2016 ◽  
Vol 7 (8) ◽  
pp. 9250-9270 ◽  
Author(s):  
Monica Benvenuto ◽  
Laura Masuelli ◽  
Enrico De Smaele ◽  
Massimo Fantini ◽  
Rosanna Mattera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth
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