scholarly journals Knockdown of interferon-induced transmembrane protein 3 expression suppresses breast cancer cell growth and colony formation and affects the cell cycle

2013 ◽  
Vol 30 (1) ◽  
pp. 171-178 ◽  
Author(s):  
MEI YANG ◽  
HONGWEN GAO ◽  
PENG CHEN ◽  
JIAOYUAN JIA ◽  
SHAN WU
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Colony Formation ◽  
Transmembrane Protein ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals MicroRNA-203 Regulates Growth and Metastasis of Breast Cancer

2015 ◽  
Vol 37 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shan Zhao ◽  
Jinzhu Han ◽  
Likang Zheng ◽  
Zixin Yang ◽  
Li Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

Backgrounds/Aims: MicroRNAs (MiRNAs) control many biological events and play critical roles in the development of tumor. Among all miRNAs, miR203 has been recently shown to have an inhibitory effect on prostate cancer. However, its involvement in the carcinogenesis of breast cancer has not been reported. Methods: We examined the levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. We also examined the levels of miR203 in several commonly used breast cancer cell lines. The effects of overexpression or depletion of miR203 on breast cancer cell growth were analyzed by a MTT assay, and on breast cancer cell invasion were examined by a scratch wound healing assay and a transwell cell migration assay. MiR203-targeted genes were analyzed by Western blot. Results: We detected significantly lower levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. Moreover, the levels of miR203 were significantly lower in breast cancer tissue from the patients with cancer metastasis. Decreased miR203 levels were detected in all examined breast cancer lines. Overexpression of miR203 inhibited breast cancer cell growth and invasion, while antisense-mediated inhibition of miR203 enhanced cancer cell growth and invasion. Further analyses show that miR203 may inhibit cell growth through decreasing cell-cycle activator cyclinD2 and CDK6, increasing cell-cycle suppressor p21 and p27, and increasing apoptosis-associated protein Bcl-2. MiR203 may also inhibit cell metastasis through suppressing matrix metalloproteinase 2 (MMP2), MMP7 and MMP9. Conclusion: Our data thus highlight miR203 as a novel therapeutic target for breast cancer.

scholarly journals ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis

2017 ◽  
Vol 39 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
Chen Wang ◽  
Chenlu Liang ◽  
Weiliang Feng ◽  
Xianghou Xia ◽  
Feng Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Pengyun Li ◽  
Shengjie Cao ◽  
Yubing Huang ◽  
Yanan Zhang ◽  
Jie Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Therapy ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Development ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Anticancer Effects

AbstractIncreasing evidence suggests the pivotal role of hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) in cancer development and progression, indicating that HPIP inhibition may be a promising target for cancer therapy. Here, we screened compounds inhibiting breast cancer cell proliferation with HPIP fused with green fluorescent protein as a reporter. A novel agent named TXX-1-10 derived from rimonabant, an antagonist of cannabinoid receptor 1 with anticancer effects, has been discovered to reduce HPIP expression and has greater inhibitory effects on breast cancer cell growth and metastasis in vitro and in vivo than rimonabant. TXX-1-10 regulates HPIP downstream targets, including several important kinases involved in cancer development and progression (e.g., AKT, ERK1/2, and FAK) as well as cell cycle-, apoptosis-, migration-, and epithelial-to-mesenchymal transition (EMT)-related genes. Consistent with the results of anticancer effects, genome-wide RNA sequencing indicated that TXX-1-10 has more significant effects on regulation of the expression of genes related to DNA replication, cell cycle, apoptosis, cell adhesion, cell migration, and invasion than rimonabant. In addition, TXX-1-10 significantly regulated genes associated with the cell growth and extracellular matrix organization, many of which were shown to be regulated by HPIP. Moreover, compared with rimonabant, TXX-1-10 greatly reduces blood-brain barrier penetrability to avoid adverse central depressive effects. These findings suggest that HPIP inhibition may be a useful strategy for cancer treatment and TXX-1-10 is a promising candidate drug for cancer therapy.

scholarly journals BTG1 inhibits breast cancer cell growth through induction of cell cycle arrest and apoptosis

2013 ◽  
Vol 30 (5) ◽  
pp. 2137-2144 ◽  
Author(s):  
RAN ZHU ◽  
SHI-TAO ZOU ◽  
JIAN-MEI WAN ◽  
WEI LI ◽  
XIN-LI LI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

Cell Cycle ◽  
2009 ◽  
Vol 8 (6) ◽  
pp. 909-915 ◽  
Author(s):  
Irina N. Alimova ◽  
Bolin Liu ◽  
Zeying Fan ◽  
Susan M. Edgerton ◽  
Thomas Dillon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Breast Cancer Cell ◽  
Colony Formation ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4+ T Cells and Macrophages

2008 ◽  
Vol 180 (5) ◽  
pp. 3158-3165 ◽  
Author(s):  
Dongqing Li ◽  
Yanmei Li ◽  
Xianglei Wu ◽  
Qiao Li ◽  
Jing Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cells ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cd4 T Cells ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2 /M arrest and apoptosis

2011 ◽  
Vol 52 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Jixia Li ◽  
Feng Zhu ◽  
Ronald A. Lubet ◽  
Antonella De Luca ◽  
Clinton Grubbs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Methyl Ether ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Resistant Breast Cancer Cell

scholarly journals Differential Roles of Fibroblast Growth Factor Receptors (FGFR) 1, 2 and 3 in the Regulation of S115 Breast Cancer Cell Growth

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49970 ◽  
Author(s):  
Kati M. Tarkkonen ◽  
Emeli M. Nilsson ◽  
Tiina E. Kähkönen ◽  
Julien H. Dey ◽  
Jari E. Heikkilä ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Cell Growth ◽  
Fibroblast Growth Factor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth
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