scholarly journals AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma

Cell Cycle ◽  
2008 ◽  
Vol 7 (22) ◽  
pp. 3525-3533 ◽  
Author(s):  
Abhi Veerakumarasivam ◽  
Leonard D. Goldstein ◽  
Kasra Saeb-Parsy ◽  
Helen E. Scott ◽  
Anne Warren ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Carcinoma ◽  
Dna Damage Response ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Damage Response

scholarly journals A DNA Damage Response Gene Panel for Different Histologic Types of Epithelial Ovarian Carcinomas and Their Outcomes

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1384
Author(s):  
Ying-Cheng Chiang ◽  
Po-Han Lin ◽  
Tzu-Pin Lu ◽  
Kuan-Ting Kuo ◽  
Yi-Jou Tai ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Carcinoma ◽  
Dna Damage Response ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Gene Mutations ◽  
Rank Test ◽  
Log Rank Test ◽  
Damage Response ◽  
Chi Squared

DNA damage response (DDR) is important for maintaining genomic integrity of the cell. Aberrant DDR pathways lead to accumulation of DNA damage, genomic instability and malignant transformations. Gene mutations have been proven to be associated with epithelial ovarian cancer, and the majority of the literature has focused on BRCA. In this study, we investigated the somatic mutation of DNA damage response genes in epithelial ovarian cancer patients using a multiple-gene panel with next-generation sequencing. In all, 69 serous, 39 endometrioid and 64 clear cell carcinoma patients were enrolled. Serous carcinoma patients (69.6%) had higher percentages of DDR gene mutations compared with patients with endometrioid (33.3%) and clear cell carcinoma (26.6%) (p < 0.001, chi-squared test). The percentages of DDR gene mutations in patients with recurrence (53.9 vs. 32.9% p = 0.006, chi-squared test) or cancer-related death (59.2 vs. 34.4% p = 0.001, chi-squared test) were higher than those without recurrence or living patients. In endometrioid carcinoma, patients with ≥2 DDR gene mutations had shorter PFS (p = 0.0035, log-rank test) and OS (p = 0.015, log-rank test) than those with one mutation or none. In clear cell carcinoma, patients with ≥2 DDR gene mutations had significantly shorter PFS (p = 0.0056, log-rank test) and OS (p = 0.0046, log-rank test) than those with 1 DDR mutation or none. In the EOC patients, somatic DDR gene mutations were associated with advanced-stage tumor recurrence and tumor-related death. Type I EOC patients with DDR mutations had an unfavorable prognosis, especially for clear cell carcinoma.

DNA damage in cytologically normal urothelial cells of patients with a history of urothelial cell carcinoma

2002 ◽  
Vol 40 (3) ◽  
pp. 190-199 ◽  
Author(s):  
�lisson Marques de Miranda Cabral Gontijo ◽  
Jo�o Paulo de Castro Marcondes ◽  
Fl�via Nunes Elias ◽  
Maria Luiza Cotrim Sartor de Oliveira ◽  
Rodrigo Ot�vio Alves de Lima ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cells ◽  
Urothelial Cell Carcinoma ◽  
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