DNA damage in cytologically normal urothelial cells of patients with a history of urothelial cell carcinoma

2002 ◽  
Vol 40 (3) ◽  
pp. 190-199 ◽  
Author(s):  
�lisson Marques de Miranda Cabral Gontijo ◽  
Jo�o Paulo de Castro Marcondes ◽  
Fl�via Nunes Elias ◽  
Maria Luiza Cotrim Sartor de Oliveira ◽  
Rodrigo Ot�vio Alves de Lima ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cells ◽  
Urothelial Cell Carcinoma ◽  
History Of

scholarly journals Genetic Instability Persists in Non-Neoplastic Urothelial Cells from Patients with a History of Urothelial Cell Carcinoma

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86162 ◽  
Author(s):  
João Paulo de Castro Marcondes ◽  
Maria Luiza Cotrim Sartor de Oliveira ◽  
Alisson M. Gontijo ◽  
João Lauro Viana de Camargo ◽  
Daisy Maria Fávero Salvadori
Keyword(s):  
Cell Carcinoma ◽  
Genetic Instability ◽  
Urothelial Cell ◽  
Urothelial Cells ◽  
Urothelial Cell Carcinoma ◽  
History Of

scholarly journals Reactivation of BK Polyomavirus in Urine Cytology Is Not Associated with Urothelial Cell Carcinoma

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1412
Author(s):  
Faisal Klufah ◽  
Ghalib Mobaraki ◽  
Axel zur Hausen ◽  
Iryna V. Samarska
Keyword(s):  
Cell Carcinoma ◽  
Urine Cytology ◽  
Urothelial Cell ◽  
The Other ◽  
Urothelial Cell Carcinoma ◽  
Tissue Samples ◽  
Bk Polyomavirus ◽  
Ffpe Tissues ◽  
Immunosuppressed Patients ◽  
History Of

BK polyomavirus (BKPyV) has been associated with some high-grade and special urothelial cell carcinoma (UCC) subtypes in immunosuppressed patients. Here, we evaluated the relationship of BKPyV-positive urine cytology specimens (UCS) with UCC. A large single-institution database was retrospectively searched for UCS positive for decoy cells, suggesting BKPyV infection. These were tested for the presence of BKPyV by PCR and immunohistochemistry (IHC) in urine sediments and formalin-fixed paraffin-embedded (FFPE) tissue samples of UCC. Decoy cells were reported in 30 patients out of the database with 22.867 UCS. Of these 30 patients, 16 (53.3%) had no history of UCC. Six patients out of these 16 had a history of transplantation, 4 had a history of severe chronic medical conditions, and 6 had no chronic disease. The other fourteen patients were diagnosed with either in situ or invasive UCC of the urinary bladder (14/30; 46.6%) prior to the detection of decoy cells in the urine. Nine of these UCC patients received intravesical treatment (BCG or mitomycin) after the first presentation with UCC. However, the clinical data on the treatment of the other five UCC patients was lacking. IHC identified BKPyV-positivity in the urine samples of non-UCC and UCC patients, while no BKPyV positivity was found in FFPE tissues of primary UCCs and metastases. In addition, BKPyV-PCR results revealed the presence of BKPyV DNA in the urine of the UCC cases, yet none in the UCC tissues itself. These data strongly indicate that BKPyV reactivation is not restricted to immunosuppression. It can be found in UCS of the immunocompetent patients and may be related to the intravesical BCG or mitomycin treatment of the UCC patients.

Case 12.12

2014 ◽  
pp. 587-587
Author(s):  
Christine U. Lee ◽  
James F. Glockner
Keyword(s):  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Corpus Spongiosum ◽  
Urothelial Cell Carcinoma ◽  
Corpora Cavernosa ◽  
History Of ◽  
The Right ◽  
T2 Weighted Images

54-year-old man with a history of a prior cystectomy for bladder urothelial cell carcinoma Axial FSE T2-weighted images (Figure 12.12.1) reveal multiple hypointense masses in both corpora cavernosa (more prominent in the left than in the right) and in the base of the corpus spongiosum....

Higher Expression of miR-182 in Cytology Specimens of High-Grade Urothelial Cell Carcinoma: A Potential Diagnostic Marker

2015 ◽  
Vol 59 (1) ◽  
pp. 109-112 ◽  
Author(s):  
Shuanzeng Wei ◽  
Zhanyong Bing ◽  
Yuan Yao ◽  
Stephen R. Master ◽  
Prabodh Gupta
Keyword(s):  
Cell Carcinoma ◽  
Noncoding Rna ◽  
Urothelial Cell ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Cell Carcinoma ◽  
Rna Molecules ◽  
History Of ◽  
Potential Alternative ◽  
Normal Controls

Objective: MicroRNAs (miRs) are short noncoding RNA molecules that posttranscriptionally modulate protein expression. There are distinct miR alterations characterizing urothelial cell carcinoma (UCC) of the urinary bladder. Study Design: In this study, we investigate the possibility of using miR as a noninvasive marker in the screening of UCC. The total RNA was extracted from 75 cytology specimens including bladder or renal washings and voided urines. Cases comprise UCC (21 high grade and 6 low grade), 25 normal controls and 23 cases with a history of UCC but negative at the time of testing (negative with a positive history). The expressions of miR-96, miR-182, miR-183, miR-200c, miR-21, miR-141 and miR-30b were determined using quantitative TaqMan real-time PCR. Results and Conclusion: This study shows that the level of miR-182 is higher in cytology specimens from high-grade UCC patients as compared to normal controls. Measuring miR-182 may provide a potential alternative or adjunct approach for screening high-grade UCC.

scholarly journals AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma

Cell Cycle ◽  
2008 ◽  
Vol 7 (22) ◽  
pp. 3525-3533 ◽  
Author(s):  
Abhi Veerakumarasivam ◽  
Leonard D. Goldstein ◽  
Kasra Saeb-Parsy ◽  
Helen E. Scott ◽  
Anne Warren ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Carcinoma ◽  
Dna Damage Response ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Damage Response

scholarly journals YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage

Oncogene ◽  
2015 ◽  
Vol 35 (12) ◽  
pp. 1541-1553 ◽  
Author(s):  
E Ciamporcero ◽  
H Shen ◽  
S Ramakrishnan ◽  
S Yu Ku ◽  
S Chintala ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma

Whorled Urothelial Cell Carcinoma

2014 ◽  
Vol 22 (5) ◽  
pp. 408-413
Author(s):  
Carlo Patriarca ◽  
Eva Comperat ◽  
Enrico Bollito ◽  
Agazio Ussia ◽  
Giovanni Scola ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma

scholarly journals Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

2012 ◽  
Vol 96 (4) ◽  
pp. 902-910 ◽  
Author(s):  
Martine M Ros ◽  
H Bas Bueno-de-Mesquita ◽  
Ellen Kampman ◽  
Katja KH Aben ◽  
Frederike L Büchner ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cell Carcinoma ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
Prospective Investigation
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