Synthesis of estradiol–pheophorbide a conjugates: evidence of nuclear targeting, DNA damage and improved photodynamic activity in human breast cancer and vascular endothelial cells

2006 ◽  
Vol 5 (11) ◽  
pp. 996-999 ◽  
Author(s):  
Naram El-Akra ◽  
Arielle Noirot ◽  
Jean-Charles Faye ◽  
Jean-Pierre Souchard
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Endothelial Cells ◽  
Human Breast Cancer ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Human Breast ◽  
Nuclear Targeting ◽  
Pheophorbide A ◽  
Photodynamic Activity

Adhesion of human breast cancer cell line MCF-7 to human vascular endothelial cells in culture. enhancement by activated platelets

1987 ◽  
Vol 40 (4) ◽  
pp. 525-531 ◽  
Author(s):  
Joseph Abecassis ◽  
RéGine Millon-Collard ◽  
Claude Klein-Soyer ◽  
Francesca Nicora ◽  
Jean-Pierre Fricker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Human Breast Cancer ◽  
Vascular Endothelial Cells ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Vascular Endothelial ◽  
Human Breast ◽  
Activated Platelets ◽  
Mcf 7

YAP Overexpression in Breast Cancer Cells Promotes Angiogenesis Through Activating Yap Signaling in Vascular Endothelial Cells

2020 ◽  
Author(s):  
Yu Yan ◽  
Qiang Song ◽  
Li Yao ◽  
Liang Zhao ◽  
Hui Cai
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Tumor Angiogenesis ◽  
Breast Cancer Cells ◽  
Vascular Endothelial Cells ◽  
Tissue Growth ◽  
Vascular Endothelial ◽  
Potential Marker

Abstract Background:The YAP signaling pathway is altered and implicated as oncogenic in human mammary cancers.However, roles of YAP signaling that regulate the breast tumor angiogenesis have remained elusive. Tumor angiogenesis is coordinated by the activation of both cancer cells and vascular endothelial cells. Whether the YAP signalingpathway can regulate the intercellular interaction between cancer cells and endothelial cellsis essentially unknown.Results: We showed here that conditioned media from YAP overexpressed breast cancer cells (CM-YAP+) could promote angiogenesis, accompanied byincreased tube formation, migration, and proliferation of human umbilical vein endothelial cells (HUVECs). Down regulation of YAP in HUVECs reversed CM-YAP+ induced angiogenesis.CM-YAP+ time-dependently activated YAP inHUVECs by dephosphorylating YAP and increasing nuclear translocation.We also identified that both G13-RhoA and PI3K/Akt signaling pathway were necessary for CM-YAP+ induced activation of YAP.Besides, connective tissue growth factor (CTGF) and angiopoietin-2 (ANG-2)actedas down-stream of YAP in HUVECs to promote angiogenesis.In addition, subcutaneous tumors nude mice model demonstrated that tumors overexpressed YAP revealed moreneovascularization in vivo.Conclusions: YAP-YAP interaction between breastcancer cells and endothelial cellscould promote tumor angiogenesis, supporting that YAP is a potential marker and target fordeveloping novel therapeutic strategies against breast cancer.

The radiosensitivity of endothelial cells isolated from human breast cancer and normal tissue in vitro

2012 ◽  
Vol 84 (2) ◽  
pp. 140-148 ◽  
Author(s):  
Moon-Taek Park ◽  
Eun-Taex Oh ◽  
Min-Jeong Song ◽  
Woo-Jean Kim ◽  
Young Up Cho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endothelial Cells ◽  
Human Breast Cancer ◽  
Normal Tissue ◽  
Human Breast

INTRACELLULAR SODIUM PROTECTS VASCULAR ENDOTHELIAL CELLS FROM APOPTOSIS TRIGGERED BY [3H]-DECAY-INDUCED DNA DAMAGE

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S50-S51
Author(s):  
S. Taurin ◽  
D. Pchejetski ◽  
N. Thorin-Trescase ◽  
J. Tremblay ◽  
P. Harriet ◽  
...  
Keyword(s):  
Dna Damage ◽  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Intracellular Sodium ◽  
Vascular Endothelial
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