scholarly journals Rethinking the Mitochondrial Theory of Aging: The Role of Mitochondrial Gene Expression in Lifespan Determination

Cell Cycle ◽  
2007 ◽  
Vol 6 (13) ◽  
pp. 1574-1578 ◽  
Author(s):  
Nicholas D. Bonawitz ◽  
Gerald S. Shadel
Keyword(s):  
Gene Expression ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression ◽  
Theory Of Aging

The role of a conserved dodecamer sequence in yeast mitochondrial gene expression

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 757-760 ◽  
Author(s):  
Ronald A. Butow ◽  
Hong Zhu ◽  
Philip Perlman ◽  
Heather Conrad-Webb
Keyword(s):  
Gene Expression ◽  
Rna Processing ◽  
Mitochondrial Gene ◽  
Rna Stability ◽  
Rrna Gene ◽  
Mitochondrial Gene Expression ◽  
Reading Frame ◽  
Multicomponent Complex ◽  
Var1 Gene

All mRNAs on the yeast mitochondrial genome terminate at a conserved dodecamer sequence 5′-AAUAAUAUUCUU-3′. We have characterized two mutants with altered dodecamers. One contains a deletion of the dodecamer at the end of the var1 gene, and the other contains two adjacent transversions in the dodecamer at the end of the reading frame of fit1, a gene within the ω+ allele of the 21S rRNA gene. In each mutant, expression of the respective gene is blocked completely. A dominant nuclear suppressor, SUV3-1, was isolated that suppresses the var1 deletion but is without effect on the fit1 dodecamer mutations. Unexpectedly, however, we found that SUV3-1 blocks expression of the wild-type fit1 allele by blocking processing at its dodecamer. SUV3-1 has pleiotropic effects on mitochondrial gene expression, affecting RNA processing, RNA stability, and translation. Our results suggest that RNA metabolism and translation may be part of a multicomponent complex within mitochondria.Key words: mitochondria, yeast, mRNA, RNA processing, 3′ dodecamer.

Regulation of mitochondrial gene expression in Saccharomyces cerevisiae: the role of RNA-binding enzymes

2001 ◽  
Vol 1 (S1) ◽  
Author(s):  
H van der Spek ◽  
M Siep ◽  
L de Jong ◽  
SDJ Elzinga ◽  
K van Oosterum ◽  
...  
Keyword(s):  
Gene Expression ◽  
Saccharomyces Cerevisiae ◽  
Rna Binding ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression

A Role of P300 in Post-natal Cardiac Mitochondrial Gene Expression and Function

2006 ◽  
Vol 12 (8) ◽  
pp. S162-S163
Author(s):  
Yasuaki Nakagawa ◽  
Koichiro Kuwahara ◽  
Masaki Harada ◽  
Genzo Takemura ◽  
Masaharu Akao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression ◽  
And Function

Role of vitamin A in mitochondrial gene expression

2001 ◽  
Vol 54 ◽  
pp. S11-S27 ◽  
Author(s):  
Carolyn D Berdanier ◽  
Helen B Everts ◽  
Christina Hermoyian ◽  
Clayton E Mathews
Keyword(s):  
Gene Expression ◽  
Vitamin A ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression

PS1-58 The role of STAT1 in regulation of mitochondrial gene expression

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 29
Author(s):  
Jennifer D. Sisler ◽  
Magdalena Szelag ◽  
Ramesh Potla ◽  
Qifang Zhang ◽  
Karol Szczepanek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression

The role of mitochondrial gene expression in ventricular fibrillation

2001 ◽  
Vol 33 (6) ◽  
pp. A117
Author(s):  
Levente Szendrei ◽  
Tibor Turoczi ◽  
Dipak K. Das ◽  
Arpad Tosaki
Keyword(s):  
Gene Expression ◽  
Ventricular Fibrillation ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression

scholarly journals Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression

2016 ◽  
Vol 291 (50) ◽  
pp. 25877-25887 ◽  
Author(s):  
Erik Boehm ◽  
María Zornoza ◽  
Alexis A. Jourdain ◽  
Aitor Delmiro Magdalena ◽  
Inés García-Consuegra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcriptional Regulation ◽  
Mitochondrial Gene ◽  
Mitochondrial Gene Expression ◽  
Post Transcriptional Regulation
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